Ptpru protein tyrosine phosphatase receptor type U [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpruprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Uprovided by MGI
Primary source: MGI:MGI:1321151
See related: Ensembl:ENSMUSG00000028909 AllianceGenome:MGI:1321151
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PTP; Pcp2; Ptpf; Ftp-1; PCP-2; Ptprl; R-PTP-U; PTPlambda; R-PTP-psi; PTP-lambda; RPTPlambda
Summary: Enables beta-catenin binding activity. Acts upstream of or within homotypic cell-cell adhesion. Predicted to be located in cell-cell junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PTPRU (protein tyrosine phosphatase receptor type U). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal adult (RPKM 20.7), bladder adult (RPKM 17.6) and 22 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4 D2.3; 4 64.5 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (131495768..131565617, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (131768457..131838306, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dlk1 is required to prevent premature expression of Dat in meso-diencephalic dopamine neuronal precursors as part of the multifaceted process of neuronal differentiation driven by Nurr1 and Pitx3.
Title: Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Ptpru (e-PCR), detects polymorphism
- UniSTS:530697

U55057 (e-PCR)
- UniSTS:163350

RH134910 (e-PCR)
- UniSTS:218188

29.MMHAP23FLB5.seq (e-PCR)
- UniSTS:123854

Ptpru (e-PCR), detects polymorphism
- UniSTS:527079

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: receptor-type tyrosine-protein phosphatase U

Names: Pancreatic carcinoma phosphatase 2; Protein-tyrosine phosphatase-lamda; Receptor-type protein-tyrosine phosphatase psi; protein tyrosine phosphatase, receptor type, L

NP_001076588.1

EC 3.1.3.48

NP_035344.2

EC 3.1.3.48

XP_006538729.1

EC 3.1.3.48

XP_006538730.1

EC 3.1.3.48

XP_006538731.1

EC 3.1.3.48

XP_006538733.1

EC 3.1.3.48

XP_006538735.1

EC 3.1.3.48

XP_006538736.1

EC 3.1.3.48

XP_006538737.1

EC 3.1.3.48

XP_011248512.1

EC 3.1.3.48

XP_011248513.1

EC 3.1.3.48

XP_011248514.1

EC 3.1.3.48

XP_011248515.1

EC 3.1.3.48

XP_011248516.1

EC 3.1.3.48

XP_011248517.1

EC 3.1.3.48

XP_036019791.1

EC 3.1.3.48

XP_036019793.1

EC 3.1.3.48

XP_036019794.1

EC 3.1.3.48

XP_036019795.1

EC 3.1.3.48

XP_036019796.1

EC 3.1.3.48

XP_036019797.1

EC 3.1.3.48

XP_036019798.1

EC 3.1.3.48

XP_036019799.1

EC 3.1.3.48

XP_036019800.1

EC 3.1.3.48

XP_036019801.1

EC 3.1.3.48

XP_036019802.1

EC 3.1.3.48

XP_036019803.1

EC 3.1.3.48

XP_036019804.1

EC 3.1.3.48

XP_036019805.1

EC 3.1.3.48

XP_036019806.1

EC 3.1.3.48

XP_036019807.1

EC 3.1.3.48

XP_036019808.1

EC 3.1.3.48

XP_036019809.1

EC 3.1.3.48

XP_036019810.1

EC 3.1.3.48

XP_036019811.1

EC 3.1.3.48

XP_036019812.1

EC 3.1.3.48

XP_036019813.1

EC 3.1.3.48

XP_036019814.1

EC 3.1.3.48

XP_036019815.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083119.3 → NP_001076588.1 receptor-type tyrosine-protein phosphatase U isoform 2 precursor

See identical proteins and their annotated locations for NP_001076588.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).

Source sequence(s)

AL670959

Consensus CDS

CCDS38896.1

UniProtKB/Swiss-Prot

B1AUH1, O35564, P70125, Q3V312, Q66JV9

Related

ENSMUSP00000030741.3, ENSMUST00000030741.9

Conserved Domains (8) summary

cd06263
Location:27 → 186

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00137
Location:22 → 186

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00194
Location:1175 → 1438

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:196 → 282

IG_like; Immunoglobulin like

cd00047
Location:922 → 1143

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:484 → 585

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:291 → 366

fn3; Fibronectin type III domain

pfam00102
Location:918 → 1143

Y_phosphatase; Protein-tyrosine phosphatase
NM_011214.3 → NP_035344.2 receptor-type tyrosine-protein phosphatase U isoform 1 precursor

See identical proteins and their annotated locations for NP_035344.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 1, which is shorter than isoform 2.

Source sequence(s)

AL670959

Consensus CDS

CCDS18714.1

UniProtKB/Swiss-Prot

B1AUH1

UniProtKB/TrEMBL

Q80ZN2

Related

ENSMUSP00000101607.3, ENSMUST00000105987.9

Conserved Domains (8) summary

cd06263
Location:27 → 186

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00137
Location:22 → 186

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00194
Location:1165 → 1428

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:196 → 282

IG_like; Immunoglobulin like

cd00047
Location:912 → 1133

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:484 → 585

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:291 → 366

fn3; Fibronectin type III domain

pfam00102
Location:908 → 1133

Y_phosphatase; Protein-tyrosine phosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

131495768..131565617 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250210.4 → XP_011248512.1 receptor-type tyrosine-protein phosphatase U isoform X1

Conserved Domains (6) summary

smart00137
Location:31 → 194

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:204 → 290

IG; Immunoglobulin

cd00063
Location:394 → 489

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1259 → 1465

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:502 → 585

fn3; Fibronectin type III domain

cl28904
Location:951 → 1174

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163920.1 → XP_036019813.1 receptor-type tyrosine-protein phosphatase U isoform X30

Conserved Domains (4) summary

cd00063
Location:61 → 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14632
Location:608 → 812

R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1

cd14637
Location:897 → 1103

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:169 → 252

fn3; Fibronectin type III domain
XM_036163915.1 → XP_036019808.1 receptor-type tyrosine-protein phosphatase U isoform X27

Conserved Domains (4) summary

cd00063
Location:61 → 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:916 → 1122

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:169 → 252

fn3; Fibronectin type III domain

cl28904
Location:608 → 831

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163909.1 → XP_036019802.1 receptor-type tyrosine-protein phosphatase U isoform X24

Conserved Domains (6) summary

smart00410
Location:44 → 130

IG_like; Immunoglobulin like

cd00063
Location:234 → 329

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14632
Location:781 → 985

R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1

cd14637
Location:1070 → 1276

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:342 → 425

fn3; Fibronectin type III domain

cl27660
Location:7 → 34

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
XM_036163918.1 → XP_036019811.1 receptor-type tyrosine-protein phosphatase U isoform X30

Conserved Domains (4) summary

cd00063
Location:61 → 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14632
Location:608 → 812

R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1

cd14637
Location:897 → 1103

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:169 → 252

fn3; Fibronectin type III domain
XM_036163914.1 → XP_036019807.1 receptor-type tyrosine-protein phosphatase U isoform X27

Conserved Domains (4) summary

cd00063
Location:61 → 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:916 → 1122

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:169 → 252

fn3; Fibronectin type III domain

cl28904
Location:608 → 831

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163917.1 → XP_036019810.1 receptor-type tyrosine-protein phosphatase U isoform X29

Conserved Domains (4) summary

cd00063
Location:61 → 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:904 → 1110

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:169 → 252

fn3; Fibronectin type III domain

cl28904
Location:618 → 819

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163912.1 → XP_036019805.1 receptor-type tyrosine-protein phosphatase U isoform X26

Conserved Domains (4) summary

cd00063
Location:61 → 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:926 → 1132

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:169 → 252

fn3; Fibronectin type III domain

cl28904
Location:618 → 841

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163901.1 → XP_036019794.1 receptor-type tyrosine-protein phosphatase U isoform X13

Conserved Domains (6) summary

smart00137
Location:22 → 186

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:196 → 282

IG; Immunoglobulin

cd00063
Location:386 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1232 → 1438

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:494 → 577

fn3; Fibronectin type III domain

cl28904
Location:933 → 1147

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163900.1 → XP_036019793.1 receptor-type tyrosine-protein phosphatase U isoform X12

Conserved Domains (6) summary

smart00137
Location:22 → 186

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:196 → 282

IG; Immunoglobulin

cd00063
Location:386 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1235 → 1441

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:494 → 577

fn3; Fibronectin type III domain

cl28904
Location:933 → 1150

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006538673.4 → XP_006538736.1 receptor-type tyrosine-protein phosphatase U isoform X16

Conserved Domains (6) summary

smart00137
Location:22 → 186

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:196 → 282

IG_like; Immunoglobulin like

cd00063
Location:484 → 585

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1228 → 1434

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:291 → 365

fn3; Fibronectin type III domain

cl28904
Location:933 → 1143

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011250215.4 → XP_011248517.1 receptor-type tyrosine-protein phosphatase U isoform X9

Conserved Domains (6) summary

smart00137
Location:22 → 186

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:196 → 282

IG; Immunoglobulin

cd00063
Location:484 → 585

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1241 → 1447

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:291 → 365

fn3; Fibronectin type III domain

cl28904
Location:933 → 1156

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163902.1 → XP_036019795.1 receptor-type tyrosine-protein phosphatase U isoform X15

Conserved Domains (6) summary

smart00137
Location:22 → 186

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:196 → 282

IG; Immunoglobulin

cd00063
Location:386 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1229 → 1435

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:494 → 577

fn3; Fibronectin type III domain

cl28904
Location:943 → 1144

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011250213.4 → XP_011248515.1 receptor-type tyrosine-protein phosphatase U isoform X4

Conserved Domains (6) summary

smart00137
Location:22 → 186

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:196 → 282

IG_like; Immunoglobulin like

cd00063
Location:484 → 585

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1251 → 1457

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:291 → 365

fn3; Fibronectin type III domain

cl28904
Location:943 → 1166

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006538674.4 → XP_006538737.1 receptor-type tyrosine-protein phosphatase U isoform X18

Conserved Domains (6) summary

smart00137
Location:22 → 186

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:196 → 282

IG; Immunoglobulin

cd00063
Location:484 → 585

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1219 → 1425

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:291 → 365

fn3; Fibronectin type III domain

cl28904
Location:933 → 1134

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163898.1 → XP_036019791.1 receptor-type tyrosine-protein phosphatase U isoform X7

Conserved Domains (6) summary

smart00137
Location:22 → 186

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:196 → 282

IG; Immunoglobulin

cd00063
Location:386 → 481

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1245 → 1451

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:494 → 577

fn3; Fibronectin type III domain

cl28904
Location:943 → 1160

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163911.1 → XP_036019804.1 receptor-type tyrosine-protein phosphatase U isoform X25

Conserved Domains (6) summary

smart00410
Location:44 → 130

IG_like; Immunoglobulin like

cd00063
Location:234 → 329

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1067 → 1273

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:342 → 425

fn3; Fibronectin type III domain

cl27660
Location:7 → 34

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

cl28904
Location:781 → 982

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163908.1 → XP_036019801.1 receptor-type tyrosine-protein phosphatase U isoform X23

Conserved Domains (6) summary

smart00409
Location:44 → 130

IG; Immunoglobulin

cd00063
Location:234 → 329

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1077 → 1283

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:342 → 425

fn3; Fibronectin type III domain

cl27660
Location:7 → 34

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

cl28904
Location:791 → 992

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163907.1 → XP_036019800.1 receptor-type tyrosine-protein phosphatase U isoform X22

Conserved Domains (6) summary

smart00410
Location:44 → 130

IG_like; Immunoglobulin like

cd00063
Location:234 → 329

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14632
Location:791 → 995

R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1

cd14637
Location:1080 → 1286

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:342 → 425

fn3; Fibronectin type III domain

cl27660
Location:7 → 34

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
XM_036163921.1 → XP_036019814.1 receptor-type tyrosine-protein phosphatase U isoform X31

Conserved Domains (4) summary

cd00063
Location:61 → 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:894 → 1100

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:169 → 252

fn3; Fibronectin type III domain

cl28904
Location:608 → 809

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163916.1 → XP_036019809.1 receptor-type tyrosine-protein phosphatase U isoform X28

Conserved Domains (4) summary

cd00063
Location:61 → 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14632
Location:618 → 822

R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1

cd14637
Location:907 → 1113

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:169 → 252

fn3; Fibronectin type III domain
XM_036163905.1 → XP_036019798.1 receptor-type tyrosine-protein phosphatase U isoform X20

Conserved Domains (6) summary

smart00137
Location:1 → 114

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:124 → 210

IG; Immunoglobulin

cd00063
Location:314 → 409

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14632
Location:861 → 1065

R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1

cd14637
Location:1150 → 1356

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:422 → 505

fn3; Fibronectin type III domain
XM_036163904.1 → XP_036019797.1 receptor-type tyrosine-protein phosphatase U isoform X19

Conserved Domains (6) summary

smart00137
Location:1 → 114

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:124 → 210

IG_like; Immunoglobulin like

cd00063
Location:314 → 409

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14632
Location:871 → 1075

R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1

cd14637
Location:1160 → 1366

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:422 → 505

fn3; Fibronectin type III domain
XM_036163906.1 → XP_036019799.1 receptor-type tyrosine-protein phosphatase U isoform X21

Conserved Domains (6) summary

smart00137
Location:1 → 114

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:124 → 210

IG_like; Immunoglobulin like

cd00063
Location:314 → 409

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1147 → 1353

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:422 → 505

fn3; Fibronectin type III domain

cl28904
Location:861 → 1062

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163910.1 → XP_036019803.1 receptor-type tyrosine-protein phosphatase U isoform X24

Conserved Domains (6) summary

smart00410
Location:44 → 130

IG_like; Immunoglobulin like

cd00063
Location:234 → 329

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14632
Location:781 → 985

R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1

cd14637
Location:1070 → 1276

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:342 → 425

fn3; Fibronectin type III domain

cl27660
Location:7 → 34

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
XM_036163919.1 → XP_036019812.1 receptor-type tyrosine-protein phosphatase U isoform X30

Conserved Domains (4) summary

cd00063
Location:61 → 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14632
Location:608 → 812

R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1

cd14637
Location:897 → 1103

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:169 → 252

fn3; Fibronectin type III domain
XM_036163913.1 → XP_036019806.1 receptor-type tyrosine-protein phosphatase U isoform X26

Conserved Domains (4) summary

cd00063
Location:61 → 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:926 → 1132

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:169 → 252

fn3; Fibronectin type III domain

cl28904
Location:618 → 841

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011250211.4 → XP_011248513.1 receptor-type tyrosine-protein phosphatase U isoform X2

Conserved Domains (6) summary

smart00137
Location:31 → 194

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:204 → 290

IG; Immunoglobulin

cd00063
Location:394 → 489

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1256 → 1462

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:502 → 585

fn3; Fibronectin type III domain

cl28904
Location:951 → 1171

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006538667.5 → XP_006538730.1 receptor-type tyrosine-protein phosphatase U isoform X8

Conserved Domains (6) summary

smart00137
Location:31 → 194

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:204 → 290

IG_like; Immunoglobulin like

cd00063
Location:394 → 489

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1243 → 1449

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:502 → 585

fn3; Fibronectin type III domain

cl28904
Location:951 → 1158

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011250214.4 → XP_011248516.1 receptor-type tyrosine-protein phosphatase U isoform X5

Conserved Domains (6) summary

smart00137
Location:31 → 194

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:204 → 290

IG_like; Immunoglobulin like

cd00063
Location:492 → 593

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1249 → 1455

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:299 → 373

fn3; Fibronectin type III domain

cl28904
Location:941 → 1164

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011250212.4 → XP_011248514.1 receptor-type tyrosine-protein phosphatase U isoform X3

Conserved Domains (6) summary

smart00137
Location:31 → 194

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:204 → 290

IG; Immunoglobulin

cd00063
Location:394 → 489

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1253 → 1459

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:502 → 585

fn3; Fibronectin type III domain

cl28904
Location:951 → 1168

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006538670.5 → XP_006538733.1 receptor-type tyrosine-protein phosphatase U isoform X11

Conserved Domains (6) summary

smart00137
Location:31 → 194

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:204 → 290

IG; Immunoglobulin

cd00063
Location:394 → 489

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1237 → 1443

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:502 → 585

fn3; Fibronectin type III domain

cl28904
Location:951 → 1152

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006538666.5 → XP_006538729.1 receptor-type tyrosine-protein phosphatase U isoform X6

Conserved Domains (6) summary

smart00137
Location:31 → 194

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:204 → 290

IG_like; Immunoglobulin like

cd00063
Location:394 → 489

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1246 → 1452

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:502 → 585

fn3; Fibronectin type III domain

cl28904
Location:951 → 1161

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036163903.1 → XP_036019796.1 receptor-type tyrosine-protein phosphatase U isoform X17

Conserved Domains (6) summary

smart00137
Location:31 → 194

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:204 → 290

IG; Immunoglobulin

cd00063
Location:394 → 489

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14637
Location:1227 → 1433

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:502 → 585

fn3; Fibronectin type III domain

cl28904
Location:941 → 1142

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006538668.5 → XP_006538731.1 receptor-type tyrosine-protein phosphatase U isoform X10

Conserved Domains (6) summary

smart00137
Location:31 → 194

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:204 → 290

IG; Immunoglobulin

cd00063
Location:394 → 489

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14632
Location:951 → 1155

R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1

cd14637
Location:1240 → 1446

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:502 → 585

fn3; Fibronectin type III domain
XM_006538672.5 → XP_006538735.1 receptor-type tyrosine-protein phosphatase U isoform X14

Conserved Domains (6) summary

smart00137
Location:31 → 194

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:204 → 290

IG; Immunoglobulin

cd00063
Location:394 → 489

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14632
Location:941 → 1145

R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1

cd14637
Location:1230 → 1436

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:502 → 585

fn3; Fibronectin type III domain
XM_036163922.1 → XP_036019815.1 receptor-type tyrosine-protein phosphatase U isoform X32

Conserved Domains (3) summary

cd14637
Location:811 → 1017

R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2

pfam00041
Location:54 → 137

fn3; Fibronectin type III domain

cl28904
Location:503 → 726

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily