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LYPD1 LY6/PLAUR domain containing 1 [ Homo sapiens (human) ]

Gene ID: 116372, updated on 10-Dec-2024

Summary

Official Symbol
LYPD1provided by HGNC
Official Full Name
LY6/PLAUR domain containing 1provided by HGNC
Primary source
HGNC:HGNC:28431
See related
Ensembl:ENSG00000150551 MIM:610450; AllianceGenome:HGNC:28431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHTS; LYPDC1
Summary
Predicted to enable acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to act upstream of or within several processes, including behavioral fear response; cholinergic synaptic transmission; and negative regulation of protein localization to plasma membrane. Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in brain (RPKM 4.3), colon (RPKM 1.3) and 16 other tissues See more
Orthologs
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Genomic context

See LYPD1 in Genome Data Viewer
Location:
2q21.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (132643286..132671526, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (133081646..133109877, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (133400859..133429099, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 39 Neighboring gene RN7SK pseudogene 103 Neighboring gene Y-box binding protein 1 pseudogene 7 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:133362908-133363464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:133426641-133427604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16540 Neighboring gene NCK associated protein 5 Neighboring gene Sharpr-MPRA regulatory region 3189 Neighboring gene uncharacterized LOC112268439 Neighboring gene NCKAP5 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • FLJ41033, MGC29643

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylcholine receptor binding  
enables acetylcholine receptor inhibitor activity  
enables protein binding PubMed 
Component Evidence Code Pubs
located_in extracellular region  
located_in plasma membrane  
located_in side of membrane  
located_in synapse  

General protein information

Preferred Names
ly6/PLAUR domain-containing protein 1
Names
putative HeLa tumor suppressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077427.4NP_001070895.1  ly6/PLAUR domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_001070895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' UTR and 5' coding region, compared to variant 1. This results in translation initiation at a downstream AUG and a protein (isoform b) with a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC079773, AK094501, AK309668, AW014835
    Consensus CDS
    CCDS46416.1
    UniProtKB/TrEMBL
    Q53RU6
    Related
    ENSP00000340563.6, ENST00000345008.6
  2. NM_001321234.2NP_001308163.1  ly6/PLAUR domain-containing protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC079773, AK130005, AW014835
    UniProtKB/Swiss-Prot
    Q8N2G4
  3. NM_001321235.2NP_001308164.1  ly6/PLAUR domain-containing protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC010974, AC079773, AW014835, BP276862
    Consensus CDS
    CCDS46416.1
    UniProtKB/TrEMBL
    Q53RU6
  4. NM_144586.7NP_653187.3  ly6/PLAUR domain-containing protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_653187.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
    Source sequence(s)
    AC010974, AC079773, AW014835, BC017318
    Consensus CDS
    CCDS42759.1
    UniProtKB/Swiss-Prot
    H7BXW6, Q6ZP52, Q6ZWI4, Q8N2G4, Q96AC2
    Related
    ENSP00000380605.2, ENST00000397463.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    132643286..132671526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    133081646..133109877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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