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    RAB11A RAB11A, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 8766, updated on 10-Dec-2024

    Summary

    Official Symbol
    RAB11Aprovided by HGNC
    Official Full Name
    RAB11A, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9760
    See related
    Ensembl:ENSG00000103769 MIM:605570; AllianceGenome:HGNC:9760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YL8
    Summary
    The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
    Expression
    Ubiquitous expression in esophagus (RPKM 50.5), adrenal (RPKM 37.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RAB11A in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65869491..65891989)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (63678915..63701413)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (66161829..66184327)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370866 Neighboring gene uncharacterized LOC124903586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9609 Neighboring gene tRNA-Gln (anticodon CTG) 1-4 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66194834-66194998 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:66195001-66195792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66214128-66214697 Neighboring gene multiple EGF like domains 11 Neighboring gene Sharpr-MPRA regulatory region 15210 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:66246132-66246645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66249429-66249932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66249933-66250434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66256890-66257866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66272648-66273148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66273149-66273649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66274440-66274940 Neighboring gene uncharacterized LOC105370867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66315774-66316274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66316275-66316775 Neighboring gene microRNA 4311

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of RAB11A, member RAS oncogene family (RAB11A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
    Knockdown of RAB11A, member RAS oncogene family (RAB11A) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with RAB11A; predicted interaction to be relevant to vesicular transport/membrane trafficking PubMed
    Nef nef HIV-1 Nef co-localization with Rab11A GTPase is revealed by staining in the peripheral and perinuclear compartments PubMed
    nef RAB11(Q67L) mutant induces significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane PubMed
    Pr55(Gag) gag Rab11a modulates intracellular Gag expression in human cells PubMed
    gag HIV-1 Gag and viral RNA preferentially co-localize with multivesicular bodies and Rab11a endosomes PubMed
    capsid gag Overexpression of a dominant negative Rab-11 GTPase mutant reduces the release of HIV-1 by CA levels and increases the intracellular CA accumulation PubMed
    reverse transcriptase gag-pol The highest RT activity is found in Rab11a compartments and Rab7a compartments in nontreated cells after 7 and 14 days of HIV-1 challenge, respectively, suggesting that the virus is mainly located in these endosomal compartments PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC1490

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity PubMed 
    enables G protein activity PubMed 
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables dynein light intermediate chain binding PubMed 
    enables microtubule binding PubMed 
    enables myosin V binding PubMed 
    enables protein binding PubMed 
    enables syntaxin binding PubMed 
    Items 1 - 25 of 33
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport PubMed 
    involved_in amyloid-beta clearance by transcytosis PubMed 
    involved_in astral microtubule organization PubMed 
    involved_in early endosome to recycling endosome transport PubMed 
    involved_in establishment of protein localization to membrane PubMed 
    involved_in establishment of protein localization to organelle PubMed 
    involved_in establishment of vesicle localization PubMed 
    involved_in exocytosis  
    involved_in exosomal secretion PubMed 
    involved_in melanosome transport  
    involved_in melanosome transport  
    involved_in mitotic metaphase chromosome alignment PubMed 
    involved_in mitotic spindle assembly PubMed 
    involved_in multivesicular body assembly PubMed 
    involved_in neuron projection development PubMed 
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane  
    involved_in plasma membrane to endosome transport PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle PubMed 
    involved_in positive regulation of epithelial cell migration PubMed 
    involved_in positive regulation of mitotic cytokinetic process PubMed 
    involved_in protein localization to cell surface  
    involved_in protein localization to cilium PubMed 
    involved_in protein localization to plasma membrane PubMed 
    involved_in protein transmembrane transport  
    involved_in regulation of cilium assembly PubMed 
    involved_in regulation of cytokinesis PubMed 
    involved_in regulation of early endosome to recycling endosome transport PubMed 
    involved_in regulation of endocytic recycling PubMed 
    involved_in regulation of protein localization to centrosome PubMed 
    involved_in regulation of vesicle-mediated transport PubMed 
    involved_in regulation of vesicle-mediated transport PubMed 
    involved_in vesicle-mediated transport PubMed 
    involved_in vesicle-mediated transport PubMed 
    Items 1 - 25 of 33
    Items 1 - 20 of 33
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    is_active_in Golgi apparatus  
    located_in Golgi membrane PubMed 
    located_in centriolar satellite  
    located_in centriole  
    colocalizes_with centrosome PubMed 
    located_in centrosome PubMed 
    located_in cleavage furrow PubMed 
    located_in cytoplasmic vesicle PubMed 
    located_in cytoplasmic vesicle membrane  
    located_in cytosol  
    located_in endocytic vesicle membrane PubMed 
    located_in extracellular exosome PubMed 
    located_in extracellular exosome PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in intracellular membrane-bounded organelle  
    colocalizes_with kinetochore microtubule PubMed 
    located_in multivesicular body PubMed 
    located_in phagocytic vesicle PubMed 
    is_active_in postsynaptic recycling endosome  
    is_active_in postsynaptic recycling endosome PubMed 
    is_active_in postsynaptic recycling endosome PubMed 
    part_of protein-containing complex PubMed 
    located_in recycling endosome PubMed 
    located_in recycling endosome  
    located_in recycling endosome membrane  
    located_in spindle pole PubMed 
    located_in trans-Golgi network PubMed 
    is_active_in trans-Golgi network membrane PubMed 
    located_in trans-Golgi network membrane PubMed 
    is_active_in transport vesicle  
    located_in vesicle PubMed 
    Items 1 - 20 of 33

    General protein information

    Preferred Names
    ras-related protein Rab-11A
    Names
    RAB 11A, member oncogene family
    rab-11
    NP_001193765.1
    NP_004654.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206836.2NP_001193765.1  ras-related protein Rab-11A isoform 2

      See identical proteins and their annotated locations for NP_001193765.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC084854, AK300008, BC013348, BC047114, DC300743
      Consensus CDS
      CCDS58373.1
      UniProtKB/TrEMBL
      H3BMH2
      Related
      ENSP00000456420.1, ENST00000569896.1
      Conserved Domains (1) summary
      cd01868
      Location:9146
      Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
    2. NM_004663.5NP_004654.1  ras-related protein Rab-11A isoform 1

      See identical proteins and their annotated locations for NP_004654.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC084854, BC013348, BC047114, DC300743
      Consensus CDS
      CCDS10212.1
      UniProtKB/Swiss-Prot
      B2R4B6, B4DT13, P24410, P62491, Q5TZN9, Q9JLX1
      UniProtKB/TrEMBL
      B4DMN1
      Related
      ENSP00000261890.2, ENST00000261890.7
      Conserved Domains (1) summary
      cd01868
      Location:9173
      Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      65869491..65891989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      63678915..63701413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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