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    Itga5 integrin alpha 5 (fibronectin receptor alpha) [ Mus musculus (house mouse) ]

    Gene ID: 16402, updated on 24-Dec-2024

    Summary

    Official Symbol
    Itga5provided by MGI
    Official Full Name
    integrin alpha 5 (fibronectin receptor alpha)provided by MGI
    Primary source
    MGI:MGI:96604
    See related
    Ensembl:ENSMUSG00000000555 AllianceGenome:MGI:96604
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fnra; VLA5; Cd49e
    Summary
    The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain, which is proteolytically processed to generate light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in bladder adult (RPKM 50.0), limb E14.5 (RPKM 25.3) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Itga5 in Genome Data Viewer
    Location:
    15 F3; 15 58.9 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103252713..103275218, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103344286..103366791, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 84 Neighboring gene zinc finger protein 385A Neighboring gene STARR-positive B cell enhancer ABC_E5521 Neighboring gene STARR-positive B cell enhancer mm9_chr15:103177678-103177979 Neighboring gene microRNA 6963 Neighboring gene STARR-seq mESC enhancer starr_39882 Neighboring gene STARR-seq mESC enhancer starr_39884 Neighboring gene gametocyte specific factor 1 Neighboring gene MARCKS-like 1, pseudogene 3 Neighboring gene gametocyte specific factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding  
    enables cell adhesion molecule binding  
    enables epidermal growth factor receptor binding  
    enables epidermal growth factor receptor binding  
    enables integrin binding  
    enables integrin binding PubMed 
    enables integrin binding  
    enables protein binding PubMed 
    enables signaling receptor activity PubMed 
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    involved_in CD40 signaling pathway  
    involved_in CD40 signaling pathway  
    involved_in angiogenesis  
    involved_in cell adhesion  
    involved_in cell adhesion mediated by integrin  
    involved_in cell adhesion mediated by integrin  
    involved_in cell adhesion mediated by integrin  
    involved_in cell-cell adhesion  
    acts_upstream_of_or_within cell-cell adhesion mediated by integrin PubMed 
    involved_in cell-matrix adhesion  
    involved_in cell-substrate adhesion  
    involved_in cell-substrate adhesion  
    acts_upstream_of_or_within cell-substrate junction assembly PubMed 
    involved_in endodermal cell differentiation  
    involved_in endodermal cell differentiation  
    involved_in female pregnancy  
    acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules PubMed 
    involved_in heterotypic cell-cell adhesion  
    involved_in heterotypic cell-cell adhesion  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    acts_upstream_of_or_within leukocyte cell-cell adhesion PubMed 
    acts_upstream_of_or_within memory PubMed 
    involved_in negative regulation of anoikis  
    involved_in negative regulation of anoikis  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell-substrate adhesion  
    involved_in positive regulation of cell-substrate adhesion  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of sprouting angiogenesis  
    involved_in positive regulation of sprouting angiogenesis  
    involved_in regulation of angiogenesis PubMed 
    involved_in response to muscle activity PubMed 
    involved_in wound healing, spreading of epidermal cells  
    Items 1 - 25 of 37
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in cell surface PubMed 
    located_in cell surface  
    located_in cell surface  
    located_in cell-cell junction  
    colocalizes_with cell-cell junction  
    located_in cytoplasmic vesicle PubMed 
    located_in endoplasmic reticulum PubMed 
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane PubMed 
    colocalizes_with focal adhesion  
    located_in focal adhesion PubMed 
    located_in focal adhesion  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    part_of integrin alpha5-beta1 complex  
    part_of integrin alpha5-beta1 complex  
    part_of integrin complex  
    part_of integrin complex  
    is_active_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in postsynaptic membrane  
    is_active_in postsynaptic membrane  
    located_in ruffle membrane  
    colocalizes_with ruffle membrane  
    located_in synapse PubMed 
    Items 1 - 20 of 27

    General protein information

    Preferred Names
    integrin alpha-5
    Names
    CD49 antigen-like family member E
    fibronectin receptor alpha polypeptide
    fibronectin receptor subunit alpha
    integrin alpha-F

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001314041.1NP_001300970.1  integrin alpha-5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, uses a downstream translation start site, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC131721, AK142241, BC050943
      UniProtKB/TrEMBL
      Q80YP5
      Conserved Domains (2) summary
      smart00191
      Location:68122
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:169597
      Integrin_alpha2; Integrin alpha
    2. NM_010577.4NP_034707.5  integrin alpha-5 isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131721, AK142241, BC050943
      Consensus CDS
      CCDS27903.1
      UniProtKB/Swiss-Prot
      E9QN40, P11688
      UniProtKB/TrEMBL
      Q80YP5
      Related
      ENSMUSP00000023128.7, ENSMUST00000023128.8
      Conserved Domains (2) summary
      smart00191
      Location:392446
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:493925
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      103252713..103275218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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