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NSD Nuclear receptor binding SET domain protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43351, updated on 17-Dec-2024

Summary

Official Symbol
NSDprovided by FlyBase
Official Full Name
Nuclear receptor binding SET domain proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039559
Locus tag
Dmel_CG4976
See related
AllianceGenome:FB:FBgn0039559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4976; Dmel\CG4976; dMes-4; dMES-4; Mes-4; MES-4
Summary
Enables chromatin DNA binding activity; histone H3K36 dimethyltransferase activity; and transcription coactivator activity. Involved in positive regulation of canonical NF-kappaB signal transduction; positive regulation of transcription by RNA polymerase II; and retrotransposon silencing by heterochromatin formation. Located in pericentric heterochromatin and polytene chromosome. Is expressed in head mesoderm; organism; trunk mesoderm; and ventral ectoderm. Used to study Sotos syndrome 1. Human ortholog(s) of this gene implicated in Sotos syndrome (multiple); lung non-small cell carcinoma; microcephaly; myeloid leukemia (multiple); and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1); NSD2 (nuclear receptor binding SET domain protein 2); and NSD3 (nuclear receptor binding SET domain protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See NSD in Genome Data Viewer
Location:
98B6-98B6; 3-94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27932982..27937853, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23758704..23763575, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene minotaur Neighboring gene antisense RNA:CR46452 Neighboring gene nenya Neighboring gene Biorientation Defective 1 Neighboring gene mitoferrin

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
located_in chromatin  
located_in heterochromatin PubMed 
is_active_in nuclear chromosome  
is_active_in nucleus  
located_in nucleus  
located_in pericentric heterochromatin PubMed 
located_in polytene chromosome PubMed 

General protein information

Preferred Names
nuclear receptor binding SET domain protein
Names
CG4976-PA
CG4976-PB
Mes-4
NSD-PA
NSD-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27932982..27937853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276100.1 → NP_001263029.1  nuclear receptor binding SET domain protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263029.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHR6
    Conserved Domains (7) summary
    cd05837
    Location:391 → 508
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1043 → 1137
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1179 → 1229
    AWS; associated with SET domains
    smart00317
    Location:1230 → 1350
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15565
    Location:863 → 928
    PHD2_NSD; PHD finger 2 found in nuclear receptor-binding SET domain-containing (NSD) proteins
    cd15566
    Location:929 → 984
    PHD3_NSD; PHD finger 3 found in nuclear receptor-binding SET domain-containing (NSD) proteins
    cd15567
    Location:997 → 1037
    PHD4_NSD; PHD finger 4 found in nuclear receptor-binding SET domain-containing (NSD) proteins
  2. NM_170360.2 → NP_733239.1  nuclear receptor binding SET domain protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733239.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1LZ05, Q8MT36, Q9VAY5
    Related
    FBpp0084636
    Conserved Domains (7) summary
    cd05837
    Location:391 → 508
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1047 → 1141
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1183 → 1233
    AWS; associated with SET domains
    smart00317
    Location:1234 → 1354
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15565
    Location:867 → 932
    PHD2_NSD; PHD finger 2 found in nuclear receptor-binding SET domain-containing (NSD) proteins
    cd15566
    Location:933 → 988
    PHD3_NSD; PHD finger 3 found in nuclear receptor-binding SET domain-containing (NSD) proteins
    cd15567
    Location:1001 → 1041
    PHD4_NSD; PHD finger 4 found in nuclear receptor-binding SET domain-containing (NSD) proteins
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