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Nmdar1 NMDA receptor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40665, updated on 9-Dec-2024

Summary

Official Symbol
Nmdar1provided by FlyBase
Official Full Name
NMDA receptor 1provided by FlyBase
Primary source
FLYBASE:FBgn0010399
Locus tag
Dmel_CG2902
See related
AllianceGenome:FB:FBgn0010399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2902; DmelNmdar1; Dmel\CG2902; DMNMDAR1; DNmdar; dnmdar-I; DNMDAR-I; dNR1; DrNR1; dsNR1; NMDA; NMDA R1; NMDA-R1; Nmdar; NMDAR; nmdar1; NmdaR1; NMdar1; NMDAR1; nmr; nr1; NR1; NRI
Summary
Contributes to NMDA glutamate receptor activity. Involved in several processes, including behavioral response to ethanol; learning or memory; and sensory perception of touch. Located in postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is expressed in several structures, including adult head; brain; larval central nervous system; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy 101. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Nmdar1 in Genome Data Viewer
Location:
83A6-83A7; 3-47.5 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5508842..5523328, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1334564..1349050, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sodium potassium chloride cotransporter Neighboring gene Inositol 1,4,5,-trisphosphate receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene meiosis I arrest

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to NMDA glutamate receptor activity  
contributes_to NMDA glutamate receptor activity PubMed 
enables NMDA glutamate receptor activity PubMed 
enables ligand-gated monoatomic ion channel activity  
enables ligand-gated monoatomic ion channel activity  
enables signaling receptor activity  
enables signaling receptor activity  
Process Evidence Code Pubs
involved_in associative learning PubMed 
involved_in behavioral response to ethanol PubMed 
involved_in calcium ion homeostasis PubMed 
involved_in chemical synaptic transmission  
involved_in chemical synaptic transmission PubMed 
involved_in ionotropic glutamate receptor signaling pathway  
involved_in ionotropic glutamate receptor signaling pathway PubMed 
involved_in long-term memory PubMed 
involved_in long-term memory PubMed 
involved_in medium-term memory PubMed 
involved_in monoatomic ion transport  
involved_in olfactory learning PubMed 
involved_in olfactory learning PubMed 
involved_in phototaxis PubMed 
involved_in regulation of membrane potential  
involved_in regulation of membrane potential PubMed 
involved_in sensory perception of touch PubMed 
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex  
part_of NMDA selective glutamate receptor complex PubMed 
part_of ionotropic glutamate receptor complex PubMed 
located_in membrane PubMed 
located_in membrane  
is_active_in neuron projection  
is_active_in plasma membrane  
located_in postsynaptic membrane PubMed 
is_active_in synapse  

General protein information

Preferred Names
NMDA receptor 1
Names
CG2902-PA
NMDA receptor
NMDA receptor I
NMDAR
Nmdar1-PA
dNR1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5508842..5523328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169059.2 → NP_730940.1  NMDA receptor 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730940.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24418
    Related
    FBpp0078410
    Conserved Domains (7) summary
    cd06379
    Location:12 → 405
    PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
    COG0834
    Location:451 → 558
    HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
    cd13719
    Location:417 → 818
    PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:575 → 838
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:58 → 371
    ANF_receptor; Receptor family ligand binding region
    pfam10562
    Location:854 → 882
    CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    cl21456
    Location:516 → 651
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
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