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mir-1000 mir-1000 stem loop [ Drosophila melanogaster (fruit fly) ]

Gene ID: 12798261, updated on 4-Jan-2025

Summary

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Official Symbol
mir-1000provided by FlyBase
Official Full Name
mir-1000 stem loopprovided by FlyBase
Primary source
FLYBASE:FBgn0262319
Locus tag
Dmel_CR43026
See related
miRBase:MI0005862; AllianceGenome:FB:FBgn0262319
Gene type
ncRNA
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CR43026; dme-mir-1000; dme-miR-1000; Dmel\CR43026; miR-1000; MIR-1000
Summary
Enables mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing and negative regulation of glutamate secretion, neurotransmission. Is expressed in several structures, including adult brain; adult head; adult mushroom body; embryonic/larval neuromuscular junction; and synaptic neuropil domain. Used to study neurodegenerative disease. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mir-1000 in Genome Data Viewer
Location:
96E4-96E4; 3-88 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25588859..25588958, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21414581..21414680, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene musashi Neighboring gene long non-coding RNA:CR46100 Neighboring gene long non-coding RNA:CR45910 Neighboring gene uncharacterized protein Neighboring gene yellow-emperor Neighboring gene uncharacterized protein Neighboring gene Nuclear protein localization 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of RDL GABA Receptor Point Mutants on Susceptibility to Meta-Diamide and Isoxazoline Insecticides in Drosophila melanogaster. Zhou T, et al. Insects, 2024 May 6. PMID 38786890, Free PMC Article
  2. Role of MicroRNA Genes miR-1000 and miR-375 in Forming Olfactory Conditional Memory in Drosophila melanogaster. Rahman S, et al. Microrna, 2020. PMID 32013857
  3. A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity. Verma P, et al. Nat Neurosci, 2015 Mar. PMID 25643297
  4. Screening of microRNAs controlling body fat in Drosophila melanogaster and identification of miR-969 and its target, Gr47b. Redmond W, et al. PLoS One, 2019. PMID 31318925, Free PMC Article
  5. miR-958 inhibits Toll signaling and Drosomycin expression via direct targeting of Toll and Dif in Drosophila melanogaster. Li S, et al. Am J Physiol Cell Physiol, 2017 Feb 1. PMID 27974298, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic deletion of miR-1000 led to elevated apoptosis in the brain as a result of glutamatergic excitotoxicity.
    Title: A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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  • mir-1000-RA; Dmel\mir-1000-RA; CR43026-RA; Dmel\CR43026-RA
  • mir-1000-RB; Dmel\mir-1000-RB; CR43026-RB; Dmel\CR43026-RB
  • mir-1000-RM; Dmel\mir-1000-RM; CR43026-RM; Dmel\CR43026-RM

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in miRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of glutamate secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25588859..25588958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_048484.1 RNA Sequence

    Status: REVIEWED

Gene LinkOut

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Research Materials