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    LIPH lipase H [ Homo sapiens (human) ]

    Gene ID: 200879, updated on 10-Dec-2024

    Summary

    Official Symbol
    LIPHprovided by HGNC
    Official Full Name
    lipase Hprovided by HGNC
    Primary source
    HGNC:HGNC:18483
    See related
    Ensembl:ENSG00000163898 MIM:607365; AllianceGenome:HGNC:18483
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AH; LAH2; ARWH2; HYPT7; LPDLR; PLA1B; mPA-PLA1
    Summary
    This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in colon (RPKM 18.6), stomach (RPKM 18.4) and 12 other tissues See more
    Orthologs
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    Genomic context

    See LIPH in Genome Data Viewer
    Location:
    3q27.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (185506262..185552588, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (188322024..188368409, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185224050..185270376, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14975 Neighboring gene uncharacterized LOC105374254 Neighboring gene transmembrane protein 41A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20926 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185272617-185273292 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:185280735-185281348 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185281349-185281962 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185300277-185301176 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185302322-185302941 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185302942-185303560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185303561-185304179 Neighboring gene SUMO specific peptidase 2 Neighboring gene ribosomal protein L34 pseudogene 10 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185359885-185360103 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185363553-185364440 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185369908-185370106 Neighboring gene insulin like growth factor 2 mRNA binding protein 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:185406257-185407456 Neighboring gene IGF2BP2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185442702-185443202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185445539-185446390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185446391-185447242

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hypotrichosis 7
    MedGen: C1836672 OMIM: 604379 GeneReviews: Not available
    Compare labs

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heparin binding PubMed 
    enables phospholipase activity  
    enables phospholipase activity PubMed 
    enables phospholipase activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    lipase member H
    Names
    LPD lipase-related protein
    lipase, member H
    mPA-PLA1 alpha
    membrane-associated phosphatidic acid-selective phospholipase A1-alpha
    membrane-bound phosphatidic acid-selective phospholipase A1
    phospholipase A(1)
    phospholipase A1 member B
    NP_640341.1
    XP_006713592.1
    XP_011510832.1
    XP_016861341.1
    XP_054201593.1
    XP_054201594.1
    XP_054201595.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012183.1 RefSeqGene

      Range
      4994..51320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139248.3NP_640341.1  lipase member H precursor

      See identical proteins and their annotated locations for NP_640341.1

      Status: REVIEWED

      Source sequence(s)
      AC099661, AK122651, BC064941, BI965988
      Consensus CDS
      CCDS3272.1
      UniProtKB/Swiss-Prot
      A2IBA7, Q8TEC7, Q8WWY8
      UniProtKB/TrEMBL
      B4DPK4
      Related
      ENSP00000296252.4, ENST00000296252.9
      Conserved Domains (1) summary
      cd00707
      Location:39303
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      185506262..185552588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005852.3XP_016861341.1  lipase member H isoform X2

      UniProtKB/TrEMBL
      A2IBA6, B4DPK4
      Related
      ENSP00000396384.2, ENST00000424591.6
      Conserved Domains (1) summary
      cd00707
      Location:39269
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    2. XM_006713529.5XP_006713592.1  lipase member H isoform X1

      UniProtKB/TrEMBL
      B4DPK4
      Conserved Domains (1) summary
      cd00707
      Location:39273
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    3. XM_011512530.4XP_011510832.1  lipase member H isoform X3

      See identical proteins and their annotated locations for XP_011510832.1

      UniProtKB/TrEMBL
      B4DPK4
      Conserved Domains (1) summary
      cd00707
      Location:1260
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      188322024..188368409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345619.1XP_054201594.1  lipase member H isoform X2

      UniProtKB/TrEMBL
      A2IBA6, B4DPK4
    2. XM_054345618.1XP_054201593.1  lipase member H isoform X1

      UniProtKB/TrEMBL
      B4DPK4
    3. XM_054345620.1XP_054201595.1  lipase member H isoform X3

      UniProtKB/TrEMBL
      B4DPK4
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