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DHX32 DEAH-box helicase 32 (putative) [ Homo sapiens (human) ]

Gene ID: 55760, updated on 27-Nov-2024

Summary

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Official Symbol
DHX32provided by HGNC
Official Full Name
DEAH-box helicase 32 (putative)provided by HGNC
Primary source
HGNC:HGNC:16717
See related
Ensembl:ENSG00000089876 MIM:607960; AllianceGenome:HGNC:16717
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX32; DHLP1
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.2), colon (RPKM 13.8) and 25 other tissues See more
Orthologs
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Genomic context

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See DHX32 in Genome Data Viewer
Location:
10q26.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (125836337..125896485, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (126718811..126779414, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (127524906..127569861, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2924 Neighboring gene matrix metallopeptidase 21 Neighboring gene uroporphyrinogen III synthase Neighboring gene CRISPRi-validated UROS cis-regulatory element Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:127511755-127512440 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:127512660-127512879 Neighboring gene microRNA 4484 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene ReSE screen-validated silencer GRCh37_chr10:127541940-127542119 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:127569451-127570173 Neighboring gene Sharpr-MPRA regulatory region 1957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2928 Neighboring gene Sharpr-MPRA regulatory region 15703 Neighboring gene RNA, U2 small nuclear 42, pseudogene Neighboring gene fibronectin type III and ankyrin repeat domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127623020-127623520 Neighboring gene G protein subunit gamma 10 pseudogene 1 Neighboring gene FANK1 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells. Alli Z, et al. Cell Immunol, 2005 Oct. PMID 16414036
  2. Nuclear and mitochondrial localization of the putative RNA helicase DHX32. Alli Z, et al. Exp Mol Pathol, 2006 Dec. PMID 16959245
  3. A role for DHX32 in regulating T-cell apoptosis. Alli Z, et al. Anticancer Res, 2007 Jan-Feb. PMID 17352256
  4. Up-regulation and clinical relevance of novel helicase homologue DHX32 in colorectal cancer. Huang C, et al. J Exp Clin Cancer Res, 2009 Jan 22. PMID 19161603, Free PMC Article
  5. Structure and function of DEAH-box helicase 32 and its role in cancer. Wei Q, et al. Oncol Lett, 2021 May. PMID 33777205, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DEAH-box polypeptide 32 promotes hepatocellular carcinoma progression via activating the beta-catenin pathway.
    Title: DEAH-box polypeptide 32 promotes hepatocellular carcinoma progression via activating the β-catenin pathway.
  2. Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer.
    Title: Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer.
  3. DHX32 is an upstream regulator for beta-catenin, which promotes the activity of beta-catenin to upregulate expression of VEGFA in colorectal cancer cells. Depletion of DHX32 expression suppressed colorectal cancer tumor angiogenesis and tumor growth.
    Title: DHX32 Promotes Angiogenesis in Colorectal Cancer Through Augmenting β-catenin Signaling to Induce Expression of VEGFA.
  4. DHX32 may play an important role in the development of colorectal cancer and could serve as a novel biomarker for colorectal cancer after additional investigation.
    Title: Up-regulation and clinical relevance of novel helicase homologue DHX32 in colorectal cancer.
  5. In peripheral blood lymphocytes, a correlation between DHX32 and c-FLIP short expression was detected in response to different T-cell activation stimuli. Results suggest DHX32 involvement in regulating T-cell response to apoptotic stimuli.
    Title: A role for DHX32 in regulating T-cell apoptosis.
  6. Structural characterization and expression of the DDX32 gene. Expression studies show that DDX32 is widespread but specifically down-regulated in acute lymphoblastic leukemias and might play a role in normal and/or abnormal lymphopoiesis.
    Title: The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia.
  7. cloned DHX32 proximal promoter and identified a 218bp fragment containing two potential binding sites for the transcription factor nuclear factor of activated T cells (NF-AT)
    Title: The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells.
  8. dysregulated expression of DHX32 might lead to as of yet unknown changes in mitochondrial homeostasis manifested by cytoplasmic redistribution of the molecular chaperon Hsp60
    Title: Altered distribution of heat shock protein 60 (Hsp60) with dysregulated expression of DHX32.
  9. These results suggest that DHX32 is a putative RNA helicase that might be involved in regulating nuclear and mitochondrial gene expression.
    Title: Nuclear and mitochondrial localization of the putative RNA helicase DHX32.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10694, FLJ10889

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HTP PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32
DEAD/H box 32
DEAD/H helicase-like protein-1
DEAH (Asp-Glu-Ala-His) box polypeptide 32
DEAH box protein 32
huDDX32
NP_060650.2
XP_047281423.1
XP_047281424.1
XP_047281425.1
XP_047281426.1
XP_054222253.1
XP_054222254.1
XP_054222255.1
XP_054222256.1
XP_054222257.1
XP_054222258.1
XP_054222259.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018180.3 → NP_060650.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

    See identical proteins and their annotated locations for NP_060650.2

    Status: REVIEWED

    Source sequence(s)
    AL360176
    Consensus CDS
    CCDS7652.1
    UniProtKB/Swiss-Prot
    A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7
    UniProtKB/TrEMBL
    B2RD71
    Related
    ENSP00000284690.3, ENST00000284690.4
    Conserved Domains (1) summary
    COG1643
    Location:12 → 679
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    125836337..125896485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425470.1 → XP_047281426.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

    UniProtKB/Swiss-Prot
    A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7

  2. XM_047425468.1 → XP_047281424.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

  3. XM_047425469.1 → XP_047281425.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

    UniProtKB/Swiss-Prot
    A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7

  4. XM_047425467.1 → XP_047281423.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    126718811..126779414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366280.1 → XP_054222255.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

    UniProtKB/Swiss-Prot
    A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7

  2. XM_054366281.1 → XP_054222256.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

    UniProtKB/Swiss-Prot
    A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7

  3. XM_054366278.1 → XP_054222253.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

  4. XM_054366279.1 → XP_054222254.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

  5. XM_054366283.1 → XP_054222258.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

    UniProtKB/Swiss-Prot
    A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7

  6. XM_054366282.1 → XP_054222257.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

    UniProtKB/Swiss-Prot
    A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7

  7. XM_054366284.1 → XP_054222259.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

    UniProtKB/Swiss-Prot
    A8MSV2, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q7L7V1, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L7V1.1 GenPept UniProtKB/Swiss-Prot:Q7L7V1

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