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    VCY variable charge Y-linked [ Homo sapiens (human) ]

    Gene ID: 9084, updated on 10-Dec-2024

    Summary

    Official Symbol
    VCYprovided by HGNC
    Official Full Name
    variable charge Y-linkedprovided by HGNC
    Primary source
    HGNC:HGNC:12668
    See related
    Ensembl:ENSG00000129864 MIM:400012; AllianceGenome:HGNC:12668
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BPY1; VCY1; VCY1A
    Summary
    The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene encodes a small, positively charged protein. The presence of a putative bipartite nuclear localization signal suggests that this gene encodes a nuclear protein. The genome has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 20.6) See more
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    Genomic context

    See VCY in Genome Data Viewer
    Location:
    Yq11.221
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (13985772..13986473, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (14892390..14893091, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (16097652..16098353, complement)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene PSIP1 pseudogene 2 Neighboring gene anosmin 2, pseudogene Neighboring gene variable charge Y-linked 1B Neighboring gene patatin like phospholipase domain containing 4 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Interactions

    General gene information

    Clone Names

    • MGC119817

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in brain development  

    General protein information

    Preferred Names
    testis-specific basic protein Y 1
    Names
    basic charge, Y-linked 1
    basic protein on Y chromosome, 1
    testis-specific basic protein on Y, 1
    variable charge, Y chromosome
    variably charged protein Y

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032915.1 RefSeqGene

      Range
      5040..5741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004679.4NP_004670.1  testis-specific basic protein Y 1

      See identical proteins and their annotated locations for NP_004670.1

      Status: REVIEWED

      Source sequence(s)
      AF000979, AI149997
      Consensus CDS
      CCDS56617.1
      UniProtKB/Swiss-Prot
      O14598
      UniProtKB/TrEMBL
      Q4KN35
      Related
      ENSP00000250825.4, ENST00000250825.5
      Conserved Domains (1) summary
      pfam15231
      Location:1116
      VCX_VCY; Variable charge X/Y family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      13985772..13986473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      14892390..14893091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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