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dnr1 defense repressor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37575, updated on 9-Dec-2024

Summary

Official Symbol
dnr1provided by FlyBase
Official Full Name
defense repressor 1provided by FlyBase
Primary source
FLYBASE:FBgn0260866
Locus tag
Dmel_CG12489
See related
AllianceGenome:FB:FBgn0260866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12489; Dmel\CG12489; Dnr-1; dNR1; Dnr1; DNR1; Mylip
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in negative regulation of defense response to bacterium; proteasome-mediated ubiquitin-dependent protein catabolic process; and sleep. Predicted to be located in cytoskeleton. Is expressed in several structures, including antennal primordium; central brain primordium; head epidermis primordium; midline primordium; and ventral ectoderm. Used to study neurodegenerative disease. Orthologous to human MYLIP (myosin regulatory light chain interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See dnr1 in Genome Data Viewer
Location:
58E9-58F1; 2-100 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22563152..22592964, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18450657..18480469, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene plexus Neighboring gene gasoline Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45328 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity  
enables ubiquitin-protein transferase activity  
enables zinc ion binding PubMed 
Component Evidence Code Pubs
is_active_in cellular_component  
located_in cytoskeleton  

General protein information

Preferred Names
defense repressor 1
Names
CG12489-PA
CG12489-PB
defense repressor I
dnr1-PA
dnr1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22563152..22592964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274208.2 → NP_001261137.1  defense repressor 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261137.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFY0
    Conserved Domains (5) summary
    smart00295
    Location:3 → 143
    B41; Band 4.1 homologues
    cd13195
    Location:325 → 435
    FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
    pfam00373
    Location:93 → 143
    FERM_M; FERM central domain
    pfam09379
    Location:5 → 67
    FERM_N; FERM N-terminal domain
    pfam13920
    Location:544 → 589
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_137836.3 → NP_611680.2  defense repressor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611680.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SWW8, Q9W241
    Related
    FBpp0071748
    Conserved Domains (5) summary
    smart00295
    Location:3 → 143
    B41; Band 4.1 homologues
    cd13195
    Location:325 → 435
    FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
    pfam00373
    Location:93 → 143
    FERM_M; FERM central domain
    pfam09379
    Location:5 → 67
    FERM_N; FERM N-terminal domain
    pfam13920
    Location:544 → 589
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
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