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unc-52 Basement membrane proteoglycan;Basement membrane-specific heparan sulfate proteoglycan core protein;Ig-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175126, updated on 9-Dec-2024

Summary

Official Symbol
unc-52
Official Full Name
Basement membrane proteoglycan;Basement membrane-specific heparan sulfate proteoglycan core protein;Ig-like domain-containing protein
Primary source
WormBase:WBGene00006787
Locus tag
CELE_ZC101.2
See related
AllianceGenome:WB:WBGene00006787
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
An extracellular matrix structural constituent. Involved in several processes, including hemidesmosome assembly; muscle cell cellular homeostasis; and nematode pharyngeal gland morphogenesis. Located in basement membrane and striated muscle dense body. Is expressed in several structures, including intestine; non-striated muscle; pharyngeal-intestinal valve; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See unc-52 in Genome Data Viewer
Location:
chromosome: II
Exon count:
48
Sequence:
Chromosome: II; NC_003280.10 (14647321..14684456, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class epsilon-13 Neighboring gene ncRNA Neighboring gene Aamy domain-containing protein;Glycosyl hydrolase family 13 catalytic domain-containing protein Neighboring gene ncRNA Neighboring gene Protein-cysteine N-palmitoyltransferase HHAT Neighboring gene DUF148 domain-containing protein;Phage protein Neighboring gene Uncharacterized protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding  
enables extracellular matrix structural constituent PubMed 
enables structural molecule activity PubMed 
Process Evidence Code Pubs
involved_in axon guidance  
involved_in cell differentiation  
involved_in cell migration PubMed 
involved_in embryo development ending in birth or egg hatching PubMed 
involved_in fibroblast growth factor receptor signaling pathway PubMed 
involved_in hemidesmosome assembly PubMed 
involved_in locomotion PubMed 
involved_in mitochondrion organization PubMed 
involved_in muscle cell cellular homeostasis PubMed 
involved_in muscle organ development PubMed 
involved_in muscle organ morphogenesis PubMed 
involved_in myofibril assembly PubMed 
involved_in nematode larval development PubMed 
involved_in nematode pharyngeal gland morphogenesis PubMed 
involved_in nematode pharynx development PubMed 
involved_in positive regulation of locomotion PubMed 
involved_in positive regulation of ovulation PubMed 
involved_in positive regulation of sarcomere organization PubMed 
Component Evidence Code Pubs
located_in M band  
located_in basement membrane PubMed 
located_in basement membrane  
located_in cytoplasm  
located_in extracellular matrix PubMed 
located_in extracellular region  
located_in striated muscle dense body PubMed 

General protein information

Preferred Names
Basement membrane proteoglycan;Basement membrane-specific heparan sulfate proteoglycan core protein;Ig-like domain-containing protein
NP_001022488.1
  • Confirmed by transcript evidence
NP_001254438.1
  • Confirmed by transcript evidence
NP_001254439.1
  • Confirmed by transcript evidence
NP_001254440.1
  • Confirmed by transcript evidence
NP_001254442.1
  • Confirmed by transcript evidence
NP_001254443.1
  • Confirmed by transcript evidence
NP_001254444.1
  • Confirmed by transcript evidence
NP_001254445.1
  • Confirmed by transcript evidence
NP_001254446.1
  • Partially confirmed by transcript evidence
NP_001293585.1
  • Confirmed by transcript evidence
NP_001337294.1
  • Confirmed by transcript evidence
NP_001364664.1
  • Confirmed by transcript evidence
NP_497044.3
  • Confirmed by transcript evidence
NP_497045.1
  • Confirmed by transcript evidence
NP_497046.1
  • Confirmed by transcript evidence
NP_497047.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14647321..14684456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377905.2NP_001364664.1  Basement membrane-specific heparan sulfate proteoglycan core protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEI5
    Conserved Domains (16) summary
    cd05743
    Location:10751152
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00180
    Location:11721218
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:15781702
    LamB; Laminin B domain
    smart00282
    Location:35133644
    LamG; Laminin G domain
    smart00409
    Location:19322012
    IG; Immunoglobulin
    smart00410
    Location:24042486
    IG_like; Immunoglobulin like
    cd00054
    Location:34113448
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:38824040
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:416450
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00053
    Location:17481795
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:10201057
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13927
    Location:26732756
    Ig_3; Immunoglobulin domain
    cd00096
    Location:30703077
    Ig; Ig strand B [structural motif]
    cd05754
    Location:834919
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl00104
    Location:9771013
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:30673137
    Ig; Immunoglobulin domain
  2. NM_064643.10NP_497044.3  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497044.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18261, O18263, Q06561, Q6BEQ6, Q9U7E8, Q9XTD2, Q9XTI5
    Conserved Domains (16) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:23662427
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:785909
    LamB; Laminin B domain
    smart00282
    Location:28132944
    LamG; Laminin G domain
    smart00409
    Location:15121593
    IG; Immunoglobulin
    smart00410
    Location:12321312
    IG_like; Immunoglobulin like
    cd00054
    Location:27112748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:31823340
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:14181493
    ig; Immunoglobulin domain
    pfam00053
    Location:9551002
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13895
    Location:15991683
    Ig_2; Immunoglobulin domain
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain
  3. NM_001267509.3NP_001254438.1  Basement membrane-specific heparan sulfate proteoglycan core protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254438.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G1K109
    Conserved Domains (4) summary
    smart00282
    Location:314445
    LamG; Laminin G domain
    cd00054
    Location:212249
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:683841
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:255284
    EGF; EGF-like domain
  4. NM_064645.6NP_497046.1  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497046.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q06561
    Conserved Domains (13) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:23662427
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:785909
    LamB; Laminin B domain
    smart00409
    Location:15121593
    IG; Immunoglobulin
    smart00410
    Location:12321312
    IG_like; Immunoglobulin like
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:14181493
    ig; Immunoglobulin domain
    pfam00053
    Location:9551002
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13895
    Location:15991683
    Ig_2; Immunoglobulin domain
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain
  5. NM_001027317.8NP_001022488.1  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022488.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q06561
    Conserved Domains (13) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:22732334
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:785909
    LamB; Laminin B domain
    smart00409
    Location:13271407
    IG; Immunoglobulin
    smart00410
    Location:11391219
    IG_like; Immunoglobulin like
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:13251400
    ig; Immunoglobulin domain
    pfam00053
    Location:9551002
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13895
    Location:15061590
    Ig_2; Immunoglobulin domain
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain
  6. NM_064644.6NP_497045.1  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497045.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q06561
    Conserved Domains (13) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:21792240
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:785909
    LamB; Laminin B domain
    smart00409
    Location:15121593
    IG; Immunoglobulin
    smart00410
    Location:12321312
    IG_like; Immunoglobulin like
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:14181493
    ig; Immunoglobulin domain
    pfam00053
    Location:9551002
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13895
    Location:15991683
    Ig_2; Immunoglobulin domain
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain
  7. NM_001267515.3NP_001254444.1  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254444.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G348
    Conserved Domains (13) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:22672328
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:785909
    LamB; Laminin B domain
    smart00409
    Location:15121593
    IG; Immunoglobulin
    smart00410
    Location:12321312
    IG_like; Immunoglobulin like
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:14181493
    ig; Immunoglobulin domain
    pfam00053
    Location:9551002
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13895
    Location:12281312
    Ig_2; Immunoglobulin domain
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain
  8. NM_001267516.3NP_001254445.1  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254445.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G349
    Conserved Domains (13) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:22722333
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:785909
    LamB; Laminin B domain
    smart00409
    Location:15121593
    IG; Immunoglobulin
    smart00410
    Location:12321312
    IG_like; Immunoglobulin like
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:14181493
    ig; Immunoglobulin domain
    pfam00053
    Location:9551002
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13895
    Location:15991683
    Ig_2; Immunoglobulin domain
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain
  9. NM_001267517.3NP_001254446.1  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254446.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G350
    Conserved Domains (13) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:23632424
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:785909
    LamB; Laminin B domain
    smart00409
    Location:14201500
    IG; Immunoglobulin
    smart00410
    Location:12321312
    IG_like; Immunoglobulin like
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:14181493
    ig; Immunoglobulin domain
    pfam00053
    Location:9551002
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13895
    Location:15991683
    Ig_2; Immunoglobulin domain
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain
  10. NM_001267513.3NP_001254442.1  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254442.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G353
    Conserved Domains (13) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:20802141
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:785909
    LamB; Laminin B domain
    smart00409
    Location:15121593
    IG; Immunoglobulin
    smart00410
    Location:12321312
    IG_like; Immunoglobulin like
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:14181493
    ig; Immunoglobulin domain
    pfam00053
    Location:9551002
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13895
    Location:12281312
    Ig_2; Immunoglobulin domain
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain
  11. NM_001267514.4NP_001254443.1  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254443.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G354
    Conserved Domains (13) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:21732234
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:785909
    LamB; Laminin B domain
    smart00409
    Location:15121593
    IG; Immunoglobulin
    smart00410
    Location:12321312
    IG_like; Immunoglobulin like
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:14181493
    ig; Immunoglobulin domain
    pfam00053
    Location:9551002
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13895
    Location:12281312
    Ig_2; Immunoglobulin domain
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain
  12. NM_001350388.3NP_001337294.1  Basement membrane-specific heparan sulfate proteoglycan core protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1T5HUZ1
    Conserved Domains (14) summary
    cd05743
    Location:10751152
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
    cd05754
    Location:834919
    Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
    smart00408
    Location:31553216
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:11721218
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:15741698
    LamB; Laminin B domain
    smart00409
    Location:20212101
    IG; Immunoglobulin
    smart00410
    Location:23012382
    IG_like; Immunoglobulin like
    cd00112
    Location:416450
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00053
    Location:17441791
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:10201057
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    cl00104
    Location:9771013
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam13895
    Location:23872472
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:26742747
    Ig_3; Immunoglobulin domain
    cl11960
    Location:19192007
    Ig; Immunoglobulin domain
  13. NM_001267510.3NP_001254439.1  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254439.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G352
    Conserved Domains (13) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:20772138
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:496620
    LamB; Laminin B domain
    smart00409
    Location:12231304
    IG; Immunoglobulin
    smart00410
    Location:9431023
    IG_like; Immunoglobulin like
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:11291204
    ig; Immunoglobulin domain
    pfam00053
    Location:666713
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13895
    Location:13101394
    Ig_2; Immunoglobulin domain
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain
  14. NM_001267511.3NP_001254440.1  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254440.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G351
    Conserved Domains (13) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00408
    Location:21802241
    IGc2; Immunoglobulin C-2 Type
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:785909
    LamB; Laminin B domain
    smart00409
    Location:13261407
    IG; Immunoglobulin
    smart00410
    Location:12341314
    IG_like; Immunoglobulin like
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00047
    Location:12321307
    ig; Immunoglobulin domain
    pfam00053
    Location:9551002
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam13895
    Location:14131497
    Ig_2; Immunoglobulin domain
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain
  15. NM_001306656.3NP_001293585.1  Ig-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293585.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4PS79
    Conserved Domains (1) summary
    smart00408
    Location:2182
    IGc2; Immunoglobulin C-2 Type
  16. NM_064646.7NP_497047.1  Basement membrane proteoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497047.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q06561
    Conserved Domains (8) summary
    cd05743
    Location:286363
    Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
    smart00180
    Location:383429
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:785909
    LamB; Laminin B domain
    pfam07679
    Location:271356
    I-set; Immunoglobulin I-set domain
    pfam00053
    Location:9551002
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:231268
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    cl00104
    Location:188224
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl11960
    Location:45130
    Ig; Immunoglobulin domain

RNA

  1. NR_131430.1 RNA Sequence

    Status: REVIEWED

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