vab-1 Ephrin receptor 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vab-1
Official Full Name: Ephrin receptor 1
Primary source: WormBase:WBGene00006868
Locus tag: CELE_M03A1.1
See related: AllianceGenome:WB:WBGene00006868
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ephrin receptor activity and protein domain specific binding activity. Involved in several processes, including embryonic morphogenesis; oocyte maturation; and regulation of axon guidance. Located in axon and plasma membrane. Is expressed in several structures, including neuroblasts; neurons; oocyte; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant nonsyndromic deafness 88; cataract 6 multiple types; central conducting lymphatic anomaly; pancreatic cancer; and prostate cancer. Orthologous to several human genes including EPHB1 (EPH receptor B1); EPHB2 (EPH receptor B2); and EPHB3 (EPH receptor B3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See vab-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (4572000..4590970)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we find that vab-1 lies in the same genetic pathway as cdc-42 and is responsible for polarizing CDC-42 activity to the medial tip. Together, these data establish a previously uncharacterized role for polarized CDC-42, in conjunction with PAR-6, PAR-3 and an Eph receptor(vab-1), during epithelial intercalation.
Title: CDC-42 Orients Cell Migration during Epithelial Intercalation in the Caenorhabditis elegans Epidermis.
Overall locomotion speed increased with increasing nicotine concentration in all tested mutant strains except in the vab-1 mutants
Title: C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype.
Analysis of EFN-1(VAB2) expression and tissue-specific requirements is consistent with a model in which VAB-1 acts in amphid neurons, interacting with EFN-1 expressed on surrounding cells.
Title: Mechanisms of ephrin receptor protein kinase-independent signaling in amphid axon guidance in Caenorhabditis elegans.
VAB-1/Eph RTK can stop axonal outgrowth by inhibiting filopodia formation at the growth cone by activating Arp2/3 through a VAB-1/NCK-1/WSP-1 complex and by inhibiting UNC-34/Ena activity
Title: The Caenorhabditis elegans Eph receptor activates NCK and N-WASP, and inhibits Ena/VASP to regulate growth cone dynamics during axon guidance.
The germline apoptosis function of VAB-1 impacts specific cell death pathways, and may act in parallel to extracellular signal-regulated kinase MAPK signaling.
Title: Somatic gonad sheath cells and Eph receptor signaling promote germ-cell death in C. elegans.
Bridge formation requires VAB-1 kinase-dependent extension of presumptive bridge cells over scaffold cells toward the ventral midline during body wall closure
Title: Semaphorin and Eph receptor signaling guide a series of cell movements for ventral enclosure in C. elegans.
Hypoxia exerted its [adverse] effect on axon pathfinding at least in part through HIF-1-dependent regulation of the Eph receptor VAB-1.
Title: Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans.
Regulated endocytic trafficking of the VAB-1 MSP/Eph receptor contributes to the control of oocyte meiotic maturation.
Title: Regulated trafficking of the MSP/Eph receptor during oocyte meiotic maturation in C. elegans.
This study shows that mutations in ina-1 (alpha-integrin), as well as vab-1 (Eph receptor), and vab-2 (ephrin), display defects in embryonic muscle cell migration.
Title: Muscle cell migrations of C. elegans are mediated by the alpha-integrin INA-1, Eph receptor VAB-1, and a novel peptidase homologue MNP-1.
identified the VAB-1 Eph receptor protein-tyrosine kinase as a major sperm protein receptor
Title: An Eph receptor sperm-sensing control mechanism for oocyte meiotic maturation in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M03A1.1 (e-PCR)
- UniSTS:311970

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ephrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ephrin receptor 1

NP_494807.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4572000..4590970

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062406.7 → NP_494807.1 Ephrin receptor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494807.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61460, Q21477

Conserved Domains (5) summary

cd10319
Location:32 → 211

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

smart00221
Location:692 → 979

STYKc; Protein kinase; unclassified specificity

cd00063
Location:342 → 423

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05033
Location:687 → 983

PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases

pfam14575
Location:642 → 687

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain