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    Lis-1 Lissencephaly-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36791, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lis-1provided by FlyBase
    Official Full Name
    Lissencephaly-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015754
    Locus tag
    Dmel_CG8440
    See related
    AllianceGenome:FB:FBgn0015754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8440; D-Lis1; Dlis-1; DLis-1; DLIS-1; dLis1; Dlis1; DLis1; DLIS1; Dmel\CG8440; DmLIS1; l(2)k13209; l(2R)W8; Lis; Lis 1; lis-1; LIS-1; lis1; Lis1; n(2)k11702
    Summary
    Enables dynein complex binding activity. Involved in several processes, including generation of neurons; oogenesis; and transport along microtubule. Located in several cellular components, including growth cone; microtubule cytoskeleton; and neuronal cell body. Part of dynactin complex and dynein complex. Colocalizes with kinetochore; kinetochore microtubule; and spindle pole centrosome. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval midgut primordium; ganglia; germline cell; and gut section. Human ortholog(s) of this gene implicated in lissencephaly and lissencephaly 1. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Lis-1 in Genome Data Viewer
    Location:
    52F4-52F5; 2-78 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16178826..16185103)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12066331..12072608)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Protein tyrosine phosphatase 52F Neighboring gene uncharacterized protein Neighboring gene clueless Neighboring gene calypso

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein complex binding  
    enables dynein complex binding PubMed 
    enables dynein complex binding PubMed 
    enables microtubule plus-end binding  
    Items 1 - 25 of 51
    Process Evidence Code Pubs
    involved_in axo-dendritic transport PubMed 
    involved_in axonal transport PubMed 
    involved_in border follicle cell migration PubMed 
    involved_in brain morphogenesis  
    involved_in centrosome localization PubMed 
    involved_in centrosome separation PubMed 
    involved_in chorion-containing eggshell pattern formation PubMed 
    involved_in clathrin-dependent endocytosis involved in vitellogenesis PubMed 
    involved_in dendrite development PubMed 
    involved_in dendrite morphogenesis PubMed 
    involved_in establishment of mitotic spindle orientation  
    involved_in female germ-line cyst formation PubMed 
    involved_in fusome organization PubMed 
    involved_in germ cell development  
    involved_in germarium-derived cystoblast division PubMed 
    involved_in germarium-derived oocyte differentiation PubMed 
    involved_in germarium-derived oocyte fate determination PubMed 
    involved_in intracellular mRNA localization PubMed 
    involved_in intracellular protein transport PubMed 
    involved_in kinetochore organization PubMed 
    involved_in microtubule organizing center organization  
    involved_in muscle cell cellular homeostasis PubMed 
    involved_in muscle cell cellular homeostasis PubMed 
    involved_in mushroom body development PubMed 
    involved_in neuroblast proliferation PubMed 
    involved_in nuclear migration  
    involved_in nuclear migration PubMed 
    involved_in nuclear migration along microtubule PubMed 
    involved_in nucleus localization PubMed 
    involved_in oocyte fate determination PubMed 
    involved_in oocyte nucleus migration involved in oocyte dorsal/ventral axis specification PubMed 
    involved_in oogenesis PubMed 
    involved_in ovarian fusome organization PubMed 
    involved_in ovarian nurse cell to oocyte transport PubMed 
    involved_in photoreceptor cell axon guidance PubMed 
    involved_in positive regulation of BMP signaling pathway PubMed 
    involved_in positive regulation of axonogenesis PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition PubMed 
    involved_in protein localization PubMed 
    involved_in protein localization PubMed 
    involved_in protein localization to kinetochore PubMed 
    involved_in regulation of dendrite morphogenesis PubMed 
    involved_in retrograde axonal transport  
    involved_in retrograde axonal transport PubMed 
    involved_in rhabdomere development PubMed 
    involved_in spermatogenesis PubMed 
    involved_in spindle assembly PubMed 
    involved_in stem cell population maintenance PubMed 
    involved_in transport along microtubule PubMed 
    involved_in vesicle transport along microtubule  
    Items 1 - 25 of 51
    Component Evidence Code Pubs
    located_in axon PubMed 
    located_in cell cortex PubMed 
    located_in centrosome PubMed 
    is_active_in cytoplasmic microtubule  
    located_in dendrite PubMed 
    part_of dynactin complex PubMed 
    part_of dynein complex PubMed 
    located_in growth cone PubMed 
    colocalizes_with kinetochore PubMed 
    located_in kinetochore PubMed 
    colocalizes_with kinetochore microtubule PubMed 
    part_of microtubule associated complex  
    is_active_in neuron projection  
    is_active_in neuronal cell body  
    located_in neuronal cell body PubMed 
    is_active_in nuclear envelope  
    located_in spindle pole PubMed 
    colocalizes_with spindle pole centrosome PubMed 

    General protein information

    Preferred Names
    Lissencephaly-1
    Names
    CG8440-PA
    CG8440-PB
    CG8440-PF
    CG8440-PG
    Lis-1-PA
    Lis-1-PB
    Lis-1-PF
    Lis-1-PG
    Paf-AHbeta
    lissencephaly-1
    platelet-activating factor acetylhydrolase Ib beta-subunit homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16178826..16185103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057812.5 → NP_477160.1  Lissencephaly-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477160.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZJ3, O96698, Q5BI20, Q7KNS3, Q8SXJ6
      UniProtKB/TrEMBL
      A0A0B4K812
      Related
      FBpp0086375
      Conserved Domains (3) summary
      smart00667
      Location:9 → 40
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:100 → 409
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]
    2. NM_001259432.2 → NP_001246361.1  Lissencephaly-1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246361.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZJ3, O96698, Q5BI20, Q7KNS3, Q8SXJ6
      UniProtKB/TrEMBL
      A0A0B4K812
      Conserved Domains (3) summary
      smart00667
      Location:9 → 40
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:100 → 409
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]
    3. NM_176190.2 → NP_788370.1  Lissencephaly-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788370.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZJ3, O96698, Q5BI20, Q7KNS3, Q8SXJ6
      UniProtKB/TrEMBL
      A0A0B4K812
      Related
      FBpp0086379
      Conserved Domains (3) summary
      smart00667
      Location:9 → 40
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:100 → 409
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]
    4. NM_206130.2 → NP_995852.1  Lissencephaly-1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZJ3, O96698, Q5BI20, Q7KNS3, Q8SXJ6
      UniProtKB/TrEMBL
      A0A0B4K812
      Conserved Domains (3) summary
      smart00667
      Location:9 → 40
      LisH; Lissencephaly type-1-like homology motif
      cd00200
      Location:100 → 409
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]
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