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    mbl muscleblind [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36945, updated on 9-Dec-2024

    Summary

    Official Symbol
    mblprovided by FlyBase
    Official Full Name
    muscleblindprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265487
    Locus tag
    Dmel_CG33197
    See related
    AllianceGenome:FB:FBgn0265487
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG01127; CG10941; CG14477; CG33197; chaste; chst; cht; Dmel\CG33197; l(2)01038; l(2)k01212; l(2)k05507; mb1; Mbl; MBL; mbn; mm; n(2)k07110
    Summary
    Predicted to enable RNA binding activity. Involved in several processes, including muscle cell cellular homeostasis; regulation of alternative mRNA splicing, via spliceosome; and rhabdomere development. Located in nucleus; perinuclear region of cytoplasm; and sarcomere. Is expressed in several structures, including Y chromosome loop; brain; imaginal disc; somatic muscle cell; and visual system neurons. Used to study dilated cardiomyopathy; myotonic dystrophy type 1; and myotonic dystrophy type 2. Orthologous to human MBNL1 (muscleblind like splicing regulator 1); MBNL2 (muscleblind like splicing regulator 2); and MBNL3 (muscleblind like splicing regulator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See mbl in Genome Data Viewer
    Location:
    54A3-54B5; 2-82 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17216549..17379376)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13104054..13266881)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46235 Neighboring gene long non-coding RNA:CR43660 Neighboring gene long non-coding RNA:CR45997 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43661 Neighboring gene transfer RNA:Alanine-TGC 1-1 Neighboring gene long non-coding RNA:CR44344

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    mobile_element

    • Loc: 17236564-17241709 mobile_element_type = transposon:copia{}840
    • Loc: 17277272-17277615 mobile_element_type = transposon:jockey{}841

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables metal ion binding  
    enables nucleic acid binding PubMed 
    Component Evidence Code Pubs
    located_in H zone PubMed 
    located_in Z disc PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in nucleoplasm  
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm PubMed 

    General protein information

    Preferred Names
    muscleblind
    Names
    BG01127
    CG33197-PA
    CG33197-PB
    CG33197-PD
    CG33197-PH
    CG33197-PJ
    CG33197-PK
    CG33197-PM
    CG33197-PN
    CG33197-PO
    CG33197-PP
    CG33197-PR
    CG33197-PS
    CG33197-PT
    CG33197-PU
    CG33197-PV
    CG33197-PW
    CG33197-PX
    CG33197-PY
    CG33197-PZ
    MUSCLEBLIND
    chaste
    mbl-PA
    mbl-PB
    mbl-PD
    mbl-PH
    mbl-PJ
    mbl-PK
    mbl-PM
    mbl-PN
    mbl-PO
    mbl-PP
    mbl-PR
    mbl-PS
    mbl-PT
    mbl-PU
    mbl-PV
    mbl-PW
    mbl-PX
    mbl-PY
    mbl-PZ
    mindmelt

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17216549..17379376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274115.1 → NP_001261044.1  muscleblind, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261044.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG51
    2. NM_001414081.1 → NP_001401011.1  muscleblind, isoform U [Drosophila melanogaster]

      Status: REVIEWED

    3. NM_176210.2 → NP_788390.1  muscleblind, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788390.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16011
      Related
      FBpp0086146
    4. NM_001274114.1 → NP_001261043.1  muscleblind, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261043.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF98
    5. NM_001144217.2 → NP_001137689.2  muscleblind, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137689.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZI9
    6. NM_001274117.1 → NP_001261046.1  muscleblind, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261046.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7AEJ0, I7BCJ6
      Conserved Domains (1) summary
      smart00356
      Location:175 → 201
      ZnF_C3H1; zinc finger
    7. NM_001274119.1 → NP_001261048.1  muscleblind, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261048.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFA2, I7AEJ0
      Conserved Domains (1) summary
      smart00356
      Location:175 → 201
      ZnF_C3H1; zinc finger
    8. NM_001274118.1 → NP_001261047.1  muscleblind, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KET3, I7AEJ0
      Conserved Domains (1) summary
      smart00356
      Location:175 → 201
      ZnF_C3H1; zinc finger
    9. NM_001259464.2 → NP_001246393.1  muscleblind, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246393.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K835, I7BCJ2
    10. NM_001144216.3 → NP_001137688.2  muscleblind, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137688.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZJ0, I7BCJ2
    11. NM_001259462.2 → NP_001246391.1  muscleblind, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246391.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7U4, I7AEJ0
      Conserved Domains (1) summary
      smart00356
      Location:175 → 201
      ZnF_C3H1; zinc finger
    12. NM_001259466.2 → NP_001246395.1  muscleblind, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K782, I7BCJ2
    13. NM_176211.2 → NP_788391.1  muscleblind, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788391.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16008, O16009, O16010, O16011, Q86BE8, Q9V803, Q9V804
      Related
      FBpp0086144
    14. NM_176212.2 → NP_788392.1  muscleblind, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7Z877
      Related
      FBpp0086143
    15. NM_001426710.1 → NP_001413638.1  muscleblind, isoform Z [Drosophila melanogaster]

      Status: REVIEWED

    16. NM_001414085.1 → NP_001401015.1  muscleblind, isoform Y [Drosophila melanogaster]

      Status: REVIEWED

    17. NM_001414083.1 → NP_001401013.1  muscleblind, isoform W [Drosophila melanogaster]

      Status: REVIEWED

    18. NM_001414084.1 → NP_001401014.1  muscleblind, isoform X [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7Z877
    19. NM_001414082.1 → NP_001401012.1  muscleblind, isoform V [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E779, N0A2M8
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