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    Art4 Arginine methyltransferase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41219, updated on 9-Dec-2024

    Summary

    Official Symbol
    Art4provided by FlyBase
    Official Full Name
    Arginine methyltransferase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0037770
    Locus tag
    Dmel_CG5358
    See related
    AllianceGenome:FB:FBgn0037770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CARM1; CG5358; dArt 4; Dart4; DART4; Dmel\CG5358; PRMT4
    Summary
    Enables histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; and protein-arginine omega-N monomethyltransferase activity. Involved in positive regulation of ecdysone receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Part of histone methyltransferase complex. Is expressed in several structures, including embryonic/larval midgut primordium; female germline cell; ganglia; head epidermis primordium; and imaginal disc. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Art4 in Genome Data Viewer
    Location:
    85F4-85F4; 3-49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9982816..9986060, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5808538..5811782, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tipE homolog 1 Neighboring gene long non-coding RNA:CR45029 Neighboring gene uncharacterized protein Neighboring gene Glucose transporter 4 enhancer factor Neighboring gene mir-9371 stem loop Neighboring gene Gustatory receptor 85a

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytosol PubMed 
    part_of histone methyltransferase complex PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    arginine methyltransferase 4
    Names
    Art4-PA
    Art4-PB
    CARMER
    CG5358-PA
    CG5358-PB
    arginie methyl transferase 4
    arginine methyl-transferase 4
    coactivator Arg methyltransferase for Ecr/Usp
    NP_001262445.1
    NP_649963.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9982816..9986060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275516.1 → NP_001262445.1  arginine methyltransferase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NL6, Q9VH48
      UniProtKB/TrEMBL
      F0JAI1
      Conserved Domains (3) summary
      cd02440
      Location:183 → 281
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05185
      Location:53 → 430
      PRMT5; PRMT5 arginine-N-methyltransferase
      cl17171
      Location:24 → 134
      PH-like; Pleckstrin homology-like domain
    2. NM_141706.3 → NP_649963.1  arginine methyltransferase 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649963.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86NL6, Q9VH48
      UniProtKB/TrEMBL
      F0JAI1
      Related
      FBpp0081628
      Conserved Domains (3) summary
      cd02440
      Location:183 → 281
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05185
      Location:53 → 430
      PRMT5; PRMT5 arginine-N-methyltransferase
      cl17171
      Location:24 → 134
      PH-like; Pleckstrin homology-like domain
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