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Galk Galactokinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39031, updated on 17-Dec-2024

Summary

Official Symbol
Galkprovided by FlyBase
Official Full Name
Galactokinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0263199
Locus tag
Dmel_CG5288
See related
AllianceGenome:FB:FBgn0263199
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg5288; CG5288; CT16885; dGALK; Dmel\CG5288; GALK
Summary
Enables galactokinase activity. Involved in UDP-galactose biosynthetic process and galactose catabolic process via UDP-galactose. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic Malpighian tubule; and gut section. Orthologous to human GALK2 (galactokinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Galk in Genome Data Viewer
Location:
66F1-66F1; 3-28 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8982212..8986091, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8975312..8979191, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pixie Neighboring gene Signal recognition particle 68 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene smaug

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding  
enables galactokinase activity  
enables galactokinase activity  
enables galactokinase activity PubMed 
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoplasm PubMed 
is_active_in cytosol  

General protein information

Preferred Names
galactokinase
Names
CG5288-PA
CG5288-PB
CG5288-PC
CG5288-PD
Galk-PA
Galk-PB
Galk-PC
Galk-PD
NP_001189074.1
NP_648276.1
NP_729438.1
NP_729439.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8982212..8986091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168307.3 → NP_729438.1  galactokinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729438.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U34, Q9VSS5
    Related
    FBpp0076280
    Conserved Domains (3) summary
    PLN02521
    Location:32 → 485
    PLN02521; galactokinase
    pfam08544
    Location:385 → 457
    GHMP_kinases_C; GHMP kinases C terminal
    pfam10509
    Location:39 → 88
    GalKase_gal_bdg; Galactokinase galactose-binding signature
  2. NM_140019.4 → NP_648276.1  galactokinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648276.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U34, Q9VSS5
    Related
    FBpp0076281
    Conserved Domains (3) summary
    PLN02521
    Location:32 → 485
    PLN02521; galactokinase
    pfam08544
    Location:385 → 457
    GHMP_kinases_C; GHMP kinases C terminal
    pfam10509
    Location:39 → 88
    GalKase_gal_bdg; Galactokinase galactose-binding signature
  3. NM_001202145.1 → NP_001189074.1  galactokinase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189074.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U34, Q9VSS5
    Conserved Domains (3) summary
    PLN02521
    Location:32 → 485
    PLN02521; galactokinase
    pfam08544
    Location:385 → 457
    GHMP_kinases_C; GHMP kinases C terminal
    pfam10509
    Location:39 → 88
    GalKase_gal_bdg; Galactokinase galactose-binding signature
  4. NM_168308.3 → NP_729439.1  galactokinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729439.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U34, Q9VSS5
    Related
    FBpp0076282
    Conserved Domains (3) summary
    PLN02521
    Location:32 → 485
    PLN02521; galactokinase
    pfam08544
    Location:385 → 457
    GHMP_kinases_C; GHMP kinases C terminal
    pfam10509
    Location:39 → 88
    GalKase_gal_bdg; Galactokinase galactose-binding signature
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