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Galt Galactose-1-phosphate uridylyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33935, updated on 4-Jan-2025

Summary

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Official Symbol
Galtprovided by FlyBase
Official Full Name
Galactose-1-phosphate uridylyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0263200
Locus tag
Dmel_CG9232
See related
AllianceGenome:FB:FBgn0263200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9232; dGALT; Dmel\CG9232; GALT
Summary
Enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity. Involved in UDP-alpha-D-glucose metabolic process; UDP-galactose biosynthetic process; and galactose catabolic process via UDP-galactose. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; epithelium; and gut section. Used to study classic galactosemia and galactosemia. Human ortholog(s) of this gene implicated in classic galactosemia. Orthologous to human GALT (galactose-1-phosphate uridylyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Galt in Genome Data Viewer
Location:
26F6-26F6; 2-21 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6666264..6668033, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6666264..6668033, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ubiquitination factor E4A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cup Neighboring gene Serpin 27A Neighboring gene cortex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Restoring galactose metabolism without restoring GALT rescues both compromised survival in larvae and an adult climbing deficit in a GALT-null D. Melanogaster model of classic galactosemia. Daenzer JMI, et al. J Inherit Metab Dis, 2024 Sep. PMID 38960603,
  2. Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia. Jumbo-Lucioni PP, et al. Antioxid Redox Signal, 2014 May 20. PMID 23758052, Free PMC Article
  3. Memory, anticipation, action - working with Troy D. Zars. Wolf R, et al. J Neurogenet, 2020 Mar. PMID 32233838
  4. UDP-galactose 4' epimerase (GALE) is essential for development of Drosophila melanogaster. Sanders RD, et al. Dis Model Mech, 2010 Sep-Oct. PMID 20519568, Free PMC Article
  5. Acute and long-term outcomes in a Drosophila melanogaster model of classic galactosemia occur independently of galactose-1-phosphate accumulation. Daenzer JM, et al. Dis Model Mech, 2016 Nov 1. PMID 27562100, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-D-galactose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UDP-alpha-D-glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UDP-galactose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose catabolic process via UDP-galactose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose catabolic process via UDP-galactose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in galactose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Galactose-1-phosphate uridylyltransferase
Names
CG9232-PA
CG9232-PB
Galt-PA
Galt-PB
galactose-1-phosphate uridyltransferase
galactose-1-phosphate uridylyltransferase
galactose-1P uridylyltransferase
NP_001260142.1
NP_609062.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6666264..6668033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135218.3 → NP_609062.2  Galactose-1-phosphate uridylyltransferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609062.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9EQS8, Q8SXN7, Q9VMA2
    UniProtKB/TrEMBL
    M9PB52
    Related
    FBpp0078951
    Conserved Domains (2) summary
    PRK11720
    Location:1 → 350
    PRK11720; galactose-1-phosphate uridylyltransferase; Provisional
    cd00608
    Location:10 → 341
    GalT; Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme ...

  2. NM_001273213.1 → NP_001260142.1  Galactose-1-phosphate uridylyltransferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260142.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9EQS8, Q8SXN7, Q9VMA2
    UniProtKB/TrEMBL
    M9PB52
    Conserved Domains (2) summary
    PRK11720
    Location:1 → 350
    PRK11720; galactose-1-phosphate uridylyltransferase; Provisional
    cd00608
    Location:10 → 341
    GalT; Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PB52 M9PB52
Q9VMA2.2 Q9VMA2

Gene LinkOut

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