U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    gld-1 Female germline-specific tumor suppressor gld-1 [ Caenorhabditis elegans ]

    Gene ID: 172532, updated on 9-Dec-2024

    Summary

    Official Symbol
    gld-1
    Official Full Name
    Female germline-specific tumor suppressor gld-1
    Primary source
    WormBase:WBGene00001595
    Locus tag
    CELE_T23G11.3
    See related
    AllianceGenome:WB:WBGene00001595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mRNA 3'-UTR binding activity; mRNA 5'-UTR binding activity; and single-stranded RNA binding activity. Involved in several processes, including positive regulation of female gonad development; positive regulation of oocyte development; and regulation of gene expression. Located in P granule and cytosol. Is expressed in several structures, including AB; C; germ line; oocyte; and ventral nerve cord. Orthologous to human QKI (QKI, KH domain containing RNA binding). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See gld-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (7695681..7698222)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Rho-GAP domain-containing protein Neighboring gene eLRR (extracellular Leucine-Rich Repeat) ONly Neighboring gene Hepatocellular carcinoma-associated antigen 59 Neighboring gene Transmembrane protein Neighboring gene Glucosamine 6-phosphate N-acetyltransferase

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables mRNA 3'-UTR binding PubMed 
    enables mRNA 5'-UTR binding PubMed 
    enables mRNA binding  
    enables nucleic acid binding  
    enables protein binding PubMed 
    enables single-stranded RNA binding PubMed 
    Component Evidence Code Pubs
    located_in P granule PubMed 
    located_in cytoplasm PubMed 
    located_in cytosol PubMed 
    is_active_in nucleus  

    General protein information

    Preferred Names
    Female germline-specific tumor suppressor gld-1
    NP_492143.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7695681..7698222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059742.8NP_492143.1  Female germline-specific tumor suppressor gld-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492143.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02540, Q17339
      Conserved Domains (2) summary
      cd02395
      Location:206328
      SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
      pfam16544
      Location:144190
      STAR_dimer; Homodimerization region of STAR domain protein
    External link. Please review our privacy policy.