U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ain-2 ALG-1 [ Caenorhabditis elegans ]

Gene ID: 172076, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
ain-2
Official Full Name
ALG-1
Primary source
WormBase:WBGene00015007
Locus tag
CELE_B0041.2
See related
AllianceGenome:WB:WBGene00015007
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in negative regulation of gene expression; regulation of cell fate specification; and regulation of development, heterochronic. Is expressed widely. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ain-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (4653467..4660153)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene EamA domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Putative 6-pyruvoyl tetrahydrobiopterin synthase Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RNA Binding Protein Vigilin Collaborates with miRNAs To Regulate Gene Expression for Caenorhabditis elegans Larval Development. Zabinsky RA, et al. G3 (Bethesda), 2017 Aug 7. PMID 28576776, Free PMC Article
  2. Translational control of endogenous microRNA target genes in C. elegans. Hurschler BA, et al. Prog Mol Subcell Biol, 2010. PMID 19841879
  3. Correction: GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis. Jannot G, et al. PLoS Genet, 2016 Dec. PMID 28033394, Free PMC Article
  4. GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis. Jannot G, et al. PLoS Genet, 2016 Dec. PMID 27935964, Free PMC Article
  5. The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Kuzuoglu-Öztürk D, et al. Nucleic Acids Res, 2012 Jul. PMID 22402495, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GW182 family proteins AIN-1 and AIN-2 act redundantly to regulate the expression of miRNA targets, but not miRNA biogenesis.
    Title: Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.
  2. We show in vitro and in vivo that their mutations severely altered the association with AIN-1 and AIN-2. our results demonstrate that the microRNA pathway can act independently of GW182 proteins during C. elegans embryogenesis
    Title: GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis.
  3. let-7 represses translation initiation in Caenorhabditis elegans which requires the GW182 proteins AIN-1 and AIN-2.
    Title: Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in negative regulation of translational initiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of development, heterochronic IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
ALG-1
NP_001020957.2
  • Confirmed by transcript evidence
NP_001343708.1
  • Confirmed by transcript evidence
NP_001343709.1
  • Confirmed by transcript evidence
NP_001343710.1
  • Confirmed by transcript evidence
NP_001367309.1
  • Confirmed by transcript evidence
NP_001367310.1
  • Confirmed by transcript evidence
NP_001379543.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4653467..4660153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392189.1 → NP_001379543.1  ALG-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95R18

  2. NM_001379889.3 → NP_001367310.1  ALG-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KY59

  3. NM_001356820.2 → NP_001343708.1  ALG-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C358

  4. NM_001356822.4 → NP_001343709.1  ALG-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C2E8

  5. NM_001379884.1 → NP_001367309.1  ALG-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KY58

  6. NM_001025786.5 → NP_001020957.2  ALG-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001020957.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KY60

  7. NM_001356823.4 → NP_001343710.1  ALG-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C2L0
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools