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Items: 20

1.

Remodeling of global transcription patterns of C. neoformans genes mediated by stress-activated HOG signaling pathways

(Submitter supplied) The ability to sense and adapt to a hostile host environment is a crucial element for virulence of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are evoked by diverse signaling cascades, including the stress-activated HOG pathway. Despite previous analysis of central components of the HOG pathway, its downstream signaling network is poorly characterized in C. neoformans. more...
Organism:
Cryptococcus neoformans var. neoformans JEC21; Cryptococcus neoformans var. grubii
Type:
Expression profiling by array
Platform:
GPL8638
100 Samples
Download data: GPR
Series
Accession:
GSE16692
ID:
200016692
2.

Transcriptomic changes in response to host temperature stress in the pathogen Crypococcus neoformans

(Submitter supplied) Using RNA-seq we report the global changes that occur in response to host temperature stress in the pathogen, Crypococcus neoformans, and reveal that mRNA decay plays a critical role in the transcriptomic and translatomic reprogramming necessary for stress adaptation.
Organism:
Cryptococcus neoformans var. grubii
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21750
24 Samples
Download data: TXT
Series
Accession:
GSE121183
ID:
200121183
3.

The role of the Ras- and cAMP-signaling pathways in stress response and sterol biosynthesis in Cryptococcus neoformans

(Submitter supplied) The cAMP-pathway plays a central role in regulation of growth, differentiation, and virulence of human pathogenic fungi, including Cryptococcus neoformans. Three major upstream signaling regulators of the adenylyl cyclase (Cac1), Ras, Aca1 (Adenylyl cyclase-associated protein 1) and G-alpha subunit protein (Gpa1), have been identified to control the cAMP-pathway in C. neoformans, but their functional relationship remains elusive. more...
Organism:
Cryptococcus neoformans var. grubii H99; Cryptococcus neoformans var. neoformans JEC21
Type:
Expression profiling by array
Platform:
GPL8638
18 Samples
Download data: GPR
Series
Accession:
GSE17338
ID:
200017338
4.

Comparative transcriptome analysis of the CO2 sensing pathway via differential expressions of carbonic anhydrase in Cryptococcus neoformans

(Submitter supplied) Carbon dioxide (CO2) sensing, transport, and metabolism play a pivotal role in survival and proliferation of pathogenic microbes infecting human host from natural environments due to the drastic difference of CO2 levels. Carbonic anhydrases (CAs) are not only key CO2-metabolic enzymes catalyzing reversible interconversion between CO2 and bicarbonate (HCO3-), but also important CO2-signaling modulators. more...
Organism:
Cryptococcus neoformans var. neoformans JEC21; Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by array
Platform:
GPL8638
17 Samples
Download data: GPR
Series
Accession:
GSE21192
ID:
200021192
5.

Sterol-response pathways mediate alkaline survival in diverse fungi.

(Submitter supplied) To determine how the fungal sterol homeostasis pathway contributes to the fungal pH response. To do so, we compared the transcriptomes of the sre1∆ mutant strain to that of the WT H99 strain in acidic (pH 4) and alkaline (pH 8) conditions.
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27451
24 Samples
Download data: TXT
Series
Accession:
GSE147109
ID:
200147109
6.

Functional dissection of the regulatory mechanism of the atypical AP-1-like transcription factor, Yap1, in Cryptococcus neoformans

(Submitter supplied) AP-1 like transcription factors play evolutionarily conserved roles in oxidative stress responses as redox sensors in eukaryotes. In this study, we aim to elucidate the regulatory mechanism of an atypical yeast AP-1 like protein, Yap1, in the stress response and virulence of Cryptococcus neoformans. YAP1 expression was induced not only by oxidative stresses, such as H2O2 and diamide, but also by other environmental stresses, such as osmotic and membrane destabilizing stresses. more...
Organism:
Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23176
6 Samples
Download data: XLSX
Series
Accession:
GSE136832
ID:
200136832
7.

Unravelling of the novel melanin biosynthesis-signalling networks in Cryptococcus neoformans

(Submitter supplied) Melanin is an antioxidant polyphenol pigment, which is required for the pathogenicity of many human and plant fungal pathogens. Nevertheless, its comprehensive regulatory mechanism still remain elusive. In this study, we systematically analyzed melanin-regulating signaling pathways in Cryptococcus neoformans. Here we identified four core melanin-regulating TFs, Bzp4, Usv101, Mbs1, and Hob1, which are required for induction of the laccase gene (LAC1). more...
Organism:
Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23176
36 Samples
Download data: XLSX
Series
Accession:
GSE131891
ID:
200131891
8.

Molecular and Functional Characterization of the role of RNA silencing components in Cryptococcus neoformans

(Submitter supplied) The RNA interference (RNAi) mediated by homology-dependent degradation of the target mRNA with small RNA molecules plays a key role in controlling transcription and translation processes in a number of eukaryotic organisms. The RNAi machinery is also evolutionarily conserved in a wide variety of fungal species, including pathogenic fungi. To elucidate the physiological functions of the RNAi pathway in Cryptococcus neoformans that causes fungal meningitis, here we performed genetic analyses for genes encoding Argonaute (AGO1 and AGO2), RdRP (RDP1), and Dicers (DCR1 and DCR2) in both serotype A and D C. more...
Organism:
Cryptococcus neoformans var. neoformans JEC21; Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by array
Platform:
GPL8638
22 Samples
Download data: GPR
Series
Accession:
GSE21178
ID:
200021178
9.

Molecular and Functional Characterization of the role of RNA silencing components in Cryptococcus neoformans [RNAi_Serotype D]

(Submitter supplied) The RNA interference (RNAi) mediated by homology-dependent degradation of the target mRNA with small RNA molecules plays a key role in controlling transcription and translation processes in a number of eukaryotic organisms. The RNAi machinery is also evolutionarily conserved in a wide variety of fungal species, including pathogenic fungi. To elucidate the physiological functions of the RNAi pathway in Cryptococcus neoformans that causes fungal meningitis, here we performed genetic analyses for genes encoding Argonaute (AGO1 and AGO2), RdRP (RDP1), and Dicers (DCR1 and DCR2) in both serotype A and D C. more...
Organism:
Cryptococcus neoformans var. neoformans JEC21
Type:
Expression profiling by array
Platform:
GPL8638
6 Samples
Download data: GPR
Series
Accession:
GSE21177
ID:
200021177
10.

Molecular and Functional Characterization of the role of RNA silencing components in Cryptococcus neoformans [RNAi_Serotype A]

(Submitter supplied) The RNA interference (RNAi) mediated by homology-dependent degradation of the target mRNA with small RNA molecules plays a key role in controlling transcription and translation processes in a number of eukaryotic organisms. The RNAi machinery is also evolutionarily conserved in a wide variety of fungal species, including pathogenic fungi. To elucidate the physiological functions of the RNAi pathway in Cryptococcus neoformans that causes fungal meningitis, here we performed genetic analyses for genes encoding Argonaute (AGO1 and AGO2), RdRP (RDP1), and Dicers (DCR1 and DCR2) in both serotype A and D C. more...
Organism:
Cryptococcus neoformans var. neoformans JEC21; Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by array
Platform:
GPL8638
16 Samples
Download data: GPR
Series
Accession:
GSE21176
ID:
200021176
11.

The transcription factor Pdr802 regulates Titan cell production and Cryptococcus neoformans pathogenicity (RNA-Seq)

(Submitter supplied) We report on our study the role of C. neoformans transcription factor Pdr802, whose expression is highly induced under host-like conditions in vitro and is critical for C. neoformans dissemination and virulence in a mouse model of infection. We found that direct targets of Pdr802 include the calcineurin targets Had1 and Pmc1, which are important for C. neoformans virulence, the transcription factor Bzp4, which promotes cryptococcal melanization and capsule thickness, and 35 transmembrane transporters. more...
Organism:
Cryptococcus neoformans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27451
56 Samples
Download data: CSV
Series
Accession:
GSE162851
ID:
200162851
12.

The transcription factor Pdr802 regulates Titan cell production and Cryptococcus neoformans pathogenicity

(Submitter supplied) We report on our study the role of C. neoformans transcription factor Pdr802, whose expression is highly induced under host-like conditions in vitro and is critical for C. neoformans dissemination and virulence in a mouse model of infection. We found that direct targets of Pdr802 include the calcineurin targets Had1 and Pmc1, which are important for C. neoformans virulence, the transcription factor Bzp4, which promotes cryptococcal melanization and capsule thickness, and 35 transmembrane transporters. more...
Organism:
Cryptococcus neoformans
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL27451
12 Samples
Download data: BED, NARROWPEAK
Series
Accession:
GSE153134
ID:
200153134
13.

WT vs rim101 mutant gene expression under capsule inducing conditions

(Submitter supplied) Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within various tissues in order to establish a human infection. We have identified the C. neoformans Rim101 transcription factor, a highly conserved pH-response regulator in many fungal species. The rim101- mutant strain displays growth defects similar to other fungal species in the presence of alkaline pH, increased salt concentrations, and iron limitation. more...
Organism:
Cryptococcus neoformans var. grubii; Cryptococcus neoformans var. neoformans
Type:
Expression profiling by array
Platform:
GPL4009
1 Sample
Download data: GPR
Series
Accession:
GSE23929
ID:
200023929
14.

The TOR pathway plays pleiotropic roles in growth and stress responses of the fungal pathogen Cryptococcus neoformans

(Submitter supplied) The target of rapamycin (TOR) pathway is an evolutionarily conserved signal transduction system that is activated by varying nutrient and environmental signals and governs a plethora of eukaryotic biological processes, but its role in Cryptococcus neoformans remains elusive. In this study, we investigated the TOR pathway by functionally characterizing two Tor-like kinases, Tor1 and Tlk1, in C. neoformans. more...
Organism:
Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23176
9 Samples
Download data: TXT, XLSX
Series
Accession:
GSE129227
ID:
200129227
15.

Pleiotropic roles of Msi1-like protein, Msl1, in growth, differentiation, stress response, and virulence of Cryptococcus neoformans

(Submitter supplied) WD40 motif-containing Msi1-like (MSIL) proteins play pleiotropic cellular functions as a negative regulator of the Ras/cAMP-pathways and a component of chromatin assembly factor-I (CAF-I), and yet have not been studied in fungal pathogens. Here we identified and characterized an MSIL protein, Msl1, in Cryptococcus neoformans, which can cause fatal meningoencephalitis in humans. Notably, Msl1 was not a functional ortholog for the yeast Msi1 but played pleiotropic roles in C. more...
Organism:
Cryptococcus neoformans var. grubii; Cryptococcus neoformans var. neoformans JEC21; Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by array
Platform:
GPL8638
6 Samples
Download data: GPR
Series
Accession:
GSE40303
ID:
200040303
16.

A genome-wide transcriptomic analysis of radiation-responsive genes in the radiation-resistant fungus, C. neoformans

(Submitter supplied) The basidiomycetous fungus Cryptococcus has been known as radiation resistant fungi and is found in highly radioactive environments such as the damaged nuclear reactor at Chernobyl. Although Cryptococcus exhibits greater resistant for gamma radiation than the model yeast Saccharomyces cerevisiae, the resistant mechanism of gamma radiation remains elusive. To elucidate a unique regulatory system for radiation-resistance in C. more...
Organism:
Cryptococcus neoformans; Cryptococcus neoformans var. grubii H99
Type:
Expression profiling by array
Platform:
GPL18333
12 Samples
Download data: GPR
Series
Accession:
GSE80230
ID:
200080230
17.

hog1, slt2, rlm1, and msn2/4 mutants exposed to zymolyase

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array
Platform:
GPL7054
18 Samples
Download data: GPR
Series
Accession:
GSE12684
ID:
200012684
18.

msn2/4 mutant 3 hour exposure to zymolyase

(Submitter supplied) We did transcription profiling on the effect of msn2 msn4 deletion, genes involved in several stress process Keywords: cell wall stress response
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array
Platform:
GPL7054
2 Samples
Download data: GPR
Series
Accession:
GSE9934
ID:
200009934
19.

rlm1 mutant 3 hour exposure to zymolyase

(Submitter supplied) We did transcription profiling on the effect of rlm1 deletion, gene involved in cell wall stress response Keywords: cell wall stress response
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array
Platform:
GPL7054
4 Samples
Download data: GPR
Series
Accession:
GSE9933
ID:
200009933
20.

slt2 mutant 3 hour exposure to zymolyase

(Submitter supplied) We did transcription profiling on the effect of slt2 deletion, gene involved in cell wall stress response Keywords: cell wall stress response
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by array
Platform:
GPL7054
4 Samples
Download data: GPR
Series
Accession:
GSE9932
ID:
200009932

Supplemental Content

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