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Rbm25 RNA binding motif protein 25 [ Mus musculus (house mouse) ]

Gene ID: 67039, updated on 9-Dec-2024

Summary

Official Symbol
Rbm25provided by MGI
Official Full Name
RNA binding motif protein 25provided by MGI
Primary source
MGI:MGI:1914289
See related
Ensembl:ENSMUSG00000010608 AllianceGenome:MGI:1914289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RNPC7; 2600011C06Rik; 2610015J01Rik; A130095G20Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Predicted to be located in nuclear speck. Is expressed in central nervous system and sensory organ. Orthologous to human RBM25 (RNA binding motif protein 25). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 31.0), CNS E14 (RPKM 19.1) and 27 other tissues See more
Orthologs
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Genomic context

See Rbm25 in Genome Data Viewer
Location:
12 D1; 12 38.81 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (83678990..83729901)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (83632208..83683127)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9860 Neighboring gene STARR-seq mESC enhancer starr_32707 Neighboring gene STARR-seq mESC enhancer starr_32708 Neighboring gene DDB1 and CUL4 associated factor 4 Neighboring gene zinc finger, FYVE domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_32712 Neighboring gene STARR-positive B cell enhancer ABC_E1444 Neighboring gene STARR-seq mESC enhancer starr_32714 Neighboring gene STARR-seq mESC enhancer starr_32715 Neighboring gene H2A histone family, member Z pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7159 Neighboring gene presenilin 1 Neighboring gene STARR-positive B cell enhancer ABC_E3061 Neighboring gene farnesyl diphosphate synthetase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding  
enables mRNA binding  
enables mRNA binding  
Process Evidence Code Pubs
involved_in RNA splicing  
involved_in apoptotic process  
involved_in mRNA processing  
involved_in regulation of alternative mRNA splicing, via spliceosome  
involved_in regulation of alternative mRNA splicing, via spliceosome  
involved_in regulation of alternative mRNA splicing, via spliceosome  
involved_in regulation of apoptotic process  
involved_in regulation of apoptotic process  
Component Evidence Code Pubs
located_in cytoplasm  
located_in nuclear speck  
located_in nuclear speck  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364415.1NP_001351344.1  RNA-binding protein 25 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC055772
    Conserved Domains (2) summary
    smart00311
    Location:777850
    PWI; domain in splicing factors
    cd12446
    Location:106188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  2. NM_001364416.1NP_001351345.1  RNA-binding protein 25 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC055772
    Consensus CDS
    CCDS49107.1
    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Conserved Domains (2) summary
    smart00311
    Location:758831
    PWI; domain in splicing factors
    cd12446
    Location:87169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  3. NM_027349.4NP_081625.3  RNA-binding protein 25 isoform 2

    See identical proteins and their annotated locations for NP_081625.3

    Status: VALIDATED

    Source sequence(s)
    AC055772, AK011403, AK142132, BY169048, CJ063347
    Consensus CDS
    CCDS49107.1
    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Related
    ENSMUSP00000048470.9, ENSMUST00000048155.16
    Conserved Domains (2) summary
    smart00311
    Location:758831
    PWI; domain in splicing factors
    cd12446
    Location:87169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    83678990..83729901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157593.1XP_036013486.1  RNA-binding protein 25 isoform X4

    Conserved Domains (2) summary
    smart00311
    Location:740813
    PWI; domain in splicing factors
    cd12446
    Location:87169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  2. XM_006516166.4XP_006516229.1  RNA-binding protein 25 isoform X1

    See identical proteins and their annotated locations for XP_006516229.1

    Conserved Domains (2) summary
    smart00311
    Location:777850
    PWI; domain in splicing factors
    cd12446
    Location:106188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  3. XM_036157590.1XP_036013483.1  RNA-binding protein 25 isoform X2

    Conserved Domains (2) summary
    smart00311
    Location:759832
    PWI; domain in splicing factors
    cd12446
    Location:106188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  4. XM_006516168.5XP_006516231.1  RNA-binding protein 25 isoform X3

    See identical proteins and their annotated locations for XP_006516231.1

    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Conserved Domains (2) summary
    smart00311
    Location:758831
    PWI; domain in splicing factors
    cd12446
    Location:87169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  5. XM_006516164.5XP_006516227.1  RNA-binding protein 25 isoform X1

    See identical proteins and their annotated locations for XP_006516227.1

    Conserved Domains (2) summary
    smart00311
    Location:777850
    PWI; domain in splicing factors
    cd12446
    Location:106188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  6. XM_036157594.1XP_036013487.1  RNA-binding protein 25 isoform X4

    Conserved Domains (2) summary
    smart00311
    Location:740813
    PWI; domain in splicing factors
    cd12446
    Location:87169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  7. XM_036157595.1XP_036013488.1  RNA-binding protein 25 isoform X4

    Conserved Domains (2) summary
    smart00311
    Location:740813
    PWI; domain in splicing factors
    cd12446
    Location:87169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  8. XM_030246879.2XP_030102739.1  RNA-binding protein 25 isoform X5

    Conserved Domains (1) summary
    smart00311
    Location:554627
    PWI; domain in splicing factors
  9. XM_036157591.1XP_036013484.1  RNA-binding protein 25 isoform X3

    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Conserved Domains (2) summary
    smart00311
    Location:758831
    PWI; domain in splicing factors
    cd12446
    Location:87169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  10. XM_036157596.1XP_036013489.1  RNA-binding protein 25 isoform X5

    Conserved Domains (1) summary
    smart00311
    Location:554627
    PWI; domain in splicing factors
  11. XM_006516165.5XP_006516228.1  RNA-binding protein 25 isoform X1

    See identical proteins and their annotated locations for XP_006516228.1

    Conserved Domains (2) summary
    smart00311
    Location:777850
    PWI; domain in splicing factors
    cd12446
    Location:106188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  12. XM_036157589.1XP_036013482.1  RNA-binding protein 25 isoform X2

    Conserved Domains (2) summary
    smart00311
    Location:759832
    PWI; domain in splicing factors
    cd12446
    Location:106188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  13. XM_036157588.1XP_036013481.1  RNA-binding protein 25 isoform X1

    Conserved Domains (2) summary
    smart00311
    Location:777850
    PWI; domain in splicing factors
    cd12446
    Location:106188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  14. XM_036157592.1XP_036013485.1  RNA-binding protein 25 isoform X3

    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Conserved Domains (2) summary
    smart00311
    Location:758831
    PWI; domain in splicing factors
    cd12446
    Location:87169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  15. XM_030246881.2XP_030102741.1  RNA-binding protein 25 isoform X5

    Conserved Domains (1) summary
    smart00311
    Location:554627
    PWI; domain in splicing factors
  16. XM_006516169.5XP_006516232.1  RNA-binding protein 25 isoform X5

    See identical proteins and their annotated locations for XP_006516232.1

    UniProtKB/Swiss-Prot
    B2RY56
    Conserved Domains (1) summary
    smart00311
    Location:554627
    PWI; domain in splicing factors
  17. XM_036157587.1XP_036013480.1  RNA-binding protein 25 isoform X1

    Conserved Domains (2) summary
    smart00311
    Location:777850
    PWI; domain in splicing factors
    cd12446
    Location:106188
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
  18. XM_030246878.2XP_030102738.1  RNA-binding protein 25 isoform X3

    UniProtKB/Swiss-Prot
    B2RY56, Q3TPH6, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
    Conserved Domains (2) summary
    smart00311
    Location:758831
    PWI; domain in splicing factors
    cd12446
    Location:87169
    RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
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