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cv-c crossveinless c [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41749, updated on 9-Dec-2024

Summary

Official Symbol
cv-cprovided by FlyBase
Official Full Name
crossveinless cprovided by FlyBase
Primary source
FLYBASE:FBgn0285955
Locus tag
Dmel_CG34389
See related
AllianceGenome:FB:FBgn0285955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14845; CG14846; CG14847; CG14848; CG14849; CG31319; CG31330; CG34389; CG8480; Cv-c; Dmel\CG34389; l(3)06951; rhoGAP88C; RhoGAP88C
Old locus tag
CG14846; CG14847; CG31319; CG31330; Dmel_CG14846; Dmel_CG14847; Dmel_CG31319; Dmel_CG31330
Summary
Enables GTPase activator activity. Involved in several processes, including cytoskeleton organization; embryonic morphogenesis; and open tracheal system development. Located in basolateral plasma membrane. Is expressed in several structures, including brain; fan-shaped body; imaginal disc; large field neurons; and spermatozoon. Used to study gonadal dysgenesis. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein); STARD13 (StAR related lipid transfer domain containing 13); and STARD8 (StAR related lipid transfer domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See cv-c in Genome Data Viewer
Location:
88B8-88C2; 3-55 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14391683..14481713, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10217405..10307435, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44943 Neighboring gene scotti Neighboring gene mir-2281 stem loop Neighboring gene antisense RNA:CR44176 Neighboring gene natalisin Neighboring gene long non-coding RNA:CR44177 Neighboring gene HTRA2-related serine protease

Genomic regions, transcripts, and products

Bibliography

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity  
enables GTPase activator activity PubMed 
enables GTPase activator activity PubMed 
enables lipid binding  
Process Evidence Code Pubs
involved_in Malpighian tubule morphogenesis PubMed 
involved_in Rho protein signal transduction PubMed 
involved_in actin cytoskeleton organization  
involved_in assembly of actomyosin apparatus involved in cytokinesis PubMed 
involved_in cell morphogenesis PubMed 
involved_in cortical actin cytoskeleton organization PubMed 
involved_in dorsal closure PubMed 
involved_in establishment of mitotic spindle orientation PubMed 
involved_in head involution PubMed 
involved_in imaginal disc-derived wing vein morphogenesis PubMed 
involved_in maintenance of epithelial integrity, open tracheal system PubMed 
involved_in metaphase/anaphase transition of mitotic cell cycle PubMed 
involved_in midgut development PubMed 
involved_in mitotic spindle organization PubMed 
involved_in negative regulation of Rho protein signal transduction PubMed 
involved_in neuromuscular synaptic transmission PubMed 
involved_in open tracheal system development PubMed 
involved_in positive regulation of synaptic transmission PubMed 
involved_in regulation of Rho protein signal transduction  
involved_in regulation of dendrite morphogenesis PubMed 
involved_in signal transduction  
involved_in sleep PubMed 
involved_in spindle localization PubMed 
involved_in spiracle morphogenesis, open tracheal system PubMed 
involved_in tracheal pit formation in open tracheal system PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane PubMed 
located_in cell cortex PubMed 

General protein information

Preferred Names
crossveinless c
Names
CG34389-PA
CG34389-PC
CG34389-PD
crossveinless-c
cv-c-PA
cv-c-PC
cv-c-PD
lethal (3) 06951

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14391683..14481713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104318.2 → NP_001097788.1  crossveinless c, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097788.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JR05, A8WHF8
    Conserved Domains (3) summary
    cd09538
    Location:1382 → 1441
    SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
    cd04375
    Location:1893 → 2116
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    cl14643
    Location:2148 → 2343
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  2. NM_001104316.2 → NP_001097786.1  crossveinless c, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097786.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JR05, A8WHF8
    Conserved Domains (3) summary
    cd09538
    Location:1382 → 1441
    SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
    cd04375
    Location:1893 → 2116
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    cl14643
    Location:2148 → 2343
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  3. NM_169583.3 → NP_731907.1  crossveinless c, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731907.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SY28, Q9VFK2
    Related
    FBpp0111543
    Conserved Domains (3) summary
    cd09538
    Location:48 → 107
    SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
    cd04375
    Location:559 → 782
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    cl14643
    Location:814 → 1009
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
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