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    Tgm2 transglutaminase 2, C polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 21817, updated on 10-Dec-2024

    Summary

    Official Symbol
    Tgm2provided by MGI
    Official Full Name
    transglutaminase 2, C polypeptideprovided by MGI
    Primary source
    MGI:MGI:98731
    See related
    Ensembl:ENSMUSG00000037820 AllianceGenome:MGI:98731
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TG2; tTG; G[a]h; tTGas; TGase2
    Summary
    Enables protein-glutamine gamma-glutamyltransferase activity. Involved in intracellular calcium ion homeostasis; positive regulation of cell adhesion; and regulation of apoptotic cell clearance. Acts upstream of or within branching involved in salivary gland morphogenesis and salivary gland cavitation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and sensory organ. Used to study maturity-onset diabetes of the young. Orthologous to human TGM2 (transglutaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 134.3), lung adult (RPKM 130.8) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Tgm2 in Genome Data Viewer
    Location:
    2 H1; 2 78.72 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157958325..157988312, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158116405..158146392, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene regulation of nuclear pre-mRNA domain containing 1B Neighboring gene RIKEN cDNA 2010009K17 gene Neighboring gene STARR-seq mESC enhancer starr_06227 Neighboring gene STARR-seq mESC enhancer starr_06228 Neighboring gene predicted gene, 34458 Neighboring gene STARR-seq mESC enhancer starr_06229 Neighboring gene RIKEN cDNA D630003M21 gene Neighboring gene RIKEN cDNA 1700060C20 gene Neighboring gene predicted gene, 34514

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTP binding  
    enables GTP binding PubMed 
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    enables histone dopaminyltransferase activity  
    enables histone dopaminyltransferase activity  
    enables histone serotonyltransferase activity  
    enables histone serotonyltransferase activity  
    enables identical protein binding  
    enables peptidase activity  
    enables peptide histaminyltransferase activity  
    enables peptide histaminyltransferase activity  
    enables peptide noradrenalinyltransferase activity  
    enables phospholipase binding  
    enables protein domain specific binding  
    enables protein-glutamine gamma-glutamyltransferase activity  
    enables protein-glutamine gamma-glutamyltransferase activity PubMed 
    enables protein-glutamine gamma-glutamyltransferase activity  
    enables protein-glutamine glutaminase activity  
    enables protein-glutamine glutaminase activity  
    enables transaminase activity PubMed 
    Items 1 - 25 of 50
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in apoptotic cell clearance  
    involved_in apoptotic cell clearance  
    involved_in blood vessel remodeling  
    involved_in bone development  
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis PubMed 
    involved_in cellular response to cocaine  
    involved_in cellular response to cocaine  
    involved_in cellular response to dopamine  
    involved_in cellular response to dopamine  
    involved_in cellular response to serotonin  
    involved_in cellular response to serotonin  
    involved_in chromatin remodeling  
    involved_in dopamine secretion  
    acts_upstream_of_positive_effect dopamine secretion  
    involved_in gene expression  
    acts_upstream_of_positive_effect gene expression  
    involved_in negative regulation of endoplasmic reticulum calcium ion concentration PubMed 
    involved_in negative regulation of endoplasmic reticulum calcium ion concentration  
    involved_in peptide cross-linking  
    involved_in peptide cross-linking  
    involved_in peptide cross-linking PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cell adhesion PubMed 
    involved_in positive regulation of mitochondrial calcium ion concentration PubMed 
    involved_in positive regulation of mitochondrial calcium ion concentration  
    involved_in positive regulation of neurogenesis  
    involved_in positive regulation of neurogenesis  
    involved_in positive regulation of small GTPase mediated signal transduction  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of sprouting angiogenesis  
    involved_in positive regulation of sprouting angiogenesis  
    involved_in protein deamination  
    involved_in protein deamination  
    involved_in protein homooligomerization  
    involved_in protein homooligomerization  
    involved_in proteolysis  
    involved_in regulation of apoptotic cell clearance PubMed 
    involved_in regulation of apoptotic cell clearance  
    involved_in regulation of apoptotic process  
    involved_in regulation of apoptotic process  
    acts_upstream_of_or_within salivary gland cavitation PubMed 
    Items 1 - 25 of 50
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromatin  
    located_in collagen-containing extracellular matrix PubMed 
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in cytosol PubMed 
    located_in endoplasmic reticulum  
    located_in extracellular matrix  
    located_in extracellular matrix PubMed 
    located_in extracellular region  
    located_in membrane PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion  
    part_of nucleosome  
    part_of nucleosome  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    protein-glutamine gamma-glutamyltransferase 2
    Names
    C polypeptide
    TG(C)
    TGC
    TGase C
    TGase II
    TGase-2
    isopeptidase TGM2
    protein-glutamine deamidase TGM2
    protein-glutamine dopaminyltransferase TGM2
    protein-glutamine histaminyltransferase TGM2
    protein-glutamine noradrenalinyltransferase TGM2
    protein-glutamine serotonyltransferase TGM2
    protein-glutamine-gamma-glutamyltransferase
    tissue transglutaminase
    transglutaminase C
    transglutaminase II
    transglutaminase-2
    NP_033399.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009373.3NP_033399.1  protein-glutamine gamma-glutamyltransferase 2

      See identical proteins and their annotated locations for NP_033399.1

      Status: PROVISIONAL

      Source sequence(s)
      AL669824
      Consensus CDS
      CCDS16985.1
      UniProtKB/Swiss-Prot
      O88901, P21981, Q3TLV2, Q8C217, Q91VG9, Q9R1F7
      Related
      ENSMUSP00000099411.4, ENSMUST00000103122.10
      Conserved Domains (4) summary
      smart00460
      Location:269361
      TGc; Transglutaminase/protease-like homologues
      COG1305
      Location:273369
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam00868
      Location:7120
      Transglut_N; Transglutaminase family
      pfam00927
      Location:473572
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      157958325..157988312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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