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CHP1 calcineurin like EF-hand protein 1 [ Homo sapiens (human) ]

Gene ID: 11261, updated on 10-Dec-2024

Summary

Official Symbol
CHP1provided by HGNC
Official Full Name
calcineurin like EF-hand protein 1provided by HGNC
Primary source
HGNC:HGNC:17433
See related
Ensembl:ENSG00000187446 MIM:606988; AllianceGenome:HGNC:17433
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHP; p22; p24; SPAX9; Sid470p; SLC9A1BP
Summary
This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 59.2), liver (RPKM 56.3) and 25 other tissues See more
Orthologs
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Genomic context

See CHP1 in Genome Data Viewer
Location:
15q15.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41231268..41281887)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39037454..39088066)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41523466..41574085)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CIBAR1 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr15:41472354-41472904 Neighboring gene RNA, 7SL, cytoplasmic 497, pseudogene Neighboring gene exonuclease 3'-5' domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9278 Neighboring gene MPRA-validated peak2306 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:41575083-41575824 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:41577309-41578048 Neighboring gene OIP5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9279 Neighboring gene Opa interacting protein 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41628937-41629558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41629559-41630180 Neighboring gene nucleolar and spindle associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Spastic ataxia 9, autosomal recessive
MedGen: C5193100 OMIM: 618438 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ20350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding  
enables calcium ion binding PubMed 
enables calcium-dependent protein binding PubMed 
enables kinase binding  
enables microtubule binding  
enables potassium channel regulator activity PubMed 
enables protein binding PubMed 
enables protein kinase inhibitor activity  
enables sodium:proton antiporter activity  
Items 1 - 25 of 28
Process Evidence Code Pubs
involved_in cellular response to acidic pH  
involved_in cytoplasmic microtubule organization  
involved_in membrane docking  
involved_in membrane docking  
involved_in membrane fusion  
involved_in membrane organization  
involved_in microtubule bundle formation  
involved_in negative regulation of NF-kappaB transcription factor activity PubMed 
involved_in negative regulation of calcineurin-NFAT signaling cascade  
involved_in negative regulation of calcineurin-NFAT signaling cascade PubMed 
involved_in negative regulation of phosphatase activity PubMed 
involved_in negative regulation of protein autophosphorylation  
involved_in negative regulation of protein import into nucleus PubMed 
involved_in negative regulation of protein kinase activity  
involved_in negative regulation of protein phosphorylation  
involved_in negative regulation of protein ubiquitination  
involved_in positive regulation of phospholipid biosynthetic process PubMed 
involved_in positive regulation of protein glycosylation  
involved_in positive regulation of protein targeting to membrane  
involved_in positive regulation of protein transport  
involved_in positive regulation of sodium:proton antiporter activity PubMed 
involved_in positive regulation of sodium:proton antiporter activity  
involved_in potassium ion transport PubMed 
involved_in protein export from nucleus  
involved_in protein stabilization  
involved_in regulation of intracellular pH PubMed 
involved_in small GTPase-mediated signal transduction PubMed 
involved_in sodium ion transmembrane transport  
Items 1 - 25 of 28
Component Evidence Code Pubs
located_in Golgi membrane  
located_in cytoplasm  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum-Golgi intermediate compartment  
located_in extracellular exosome PubMed 
located_in focal adhesion PubMed 
located_in membrane raft  
located_in microtubule cytoskeleton  
located_in nucleus  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in transport vesicle  
part_of transporter complex  

General protein information

Preferred Names
calcineurin B homologous protein 1
Names
EF-hand calcium-binding domain-containing protein p22
SLC9A1 binding protein
calcineurin B homolog
calcineurin B-like protein
calcineurin homologous protein
calcium binding protein P22
calcium-binding protein CHP
calcium-binding protein p22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007236.5NP_009167.1  calcineurin B homologous protein 1

    See identical proteins and their annotated locations for NP_009167.1

    Status: REVIEWED

    Source sequence(s)
    AC012652
    Consensus CDS
    CCDS10073.1
    UniProtKB/Swiss-Prot
    B2R6H9, Q6FHZ9, Q99653
    Related
    ENSP00000335632.5, ENST00000334660.10
    Conserved Domains (1) summary
    COG5126
    Location:1182
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    41231268..41281887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432125.1XP_047288081.1  calcineurin B homologous protein 1 isoform X2

  2. XM_017021879.3XP_016877368.1  calcineurin B homologous protein 1 isoform X1

    UniProtKB/TrEMBL
    F5GX29, H0YKE7
    Related
    ENSP00000452772.1, ENST00000560784.5
    Conserved Domains (1) summary
    cl25352
    Location:198
    EFh_PEF; The penta-EF hand (PEF) family
  3. XM_047432124.1XP_047288080.1  calcineurin B homologous protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    39037454..39088066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377227.1XP_054233202.1  calcineurin B homologous protein 1 isoform X2

  2. XM_054377225.1XP_054233200.1  calcineurin B homologous protein 1 isoform X1

    UniProtKB/TrEMBL
    F5GX29, H0YKE7
  3. XM_054377226.1XP_054233201.1  calcineurin B homologous protein 1 isoform X2

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