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STK17B serine/threonine kinase 17b [ Homo sapiens (human) ]

Gene ID: 9262, updated on 27-Nov-2024

Summary

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Official Symbol
STK17Bprovided by HGNC
Official Full Name
serine/threonine kinase 17bprovided by HGNC
Primary source
HGNC:HGNC:11396
See related
Ensembl:ENSG00000081320 MIM:604727; AllianceGenome:HGNC:11396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRAK2
Summary
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein phosphorylation. Located in Flemming body and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bone marrow (RPKM 54.0), lymph node (RPKM 45.0) and 18 other tissues See more
Orthologs
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Genomic context

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See STK17B in Genome Data Viewer
Location:
2q32.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (196133583..196176483, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (196617655..196666801, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (196998307..197036302, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 7 Neighboring gene E2F transcription factor 3 pseudogene 2 Neighboring gene glutathione S-transferase alpha 5 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16892 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:196961660-196962248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16895 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:196977894-196978422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:197023734-197024234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12202 Neighboring gene uncharacterized LOC101927454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16899 Neighboring gene small nucleolar RNA U13 Neighboring gene MPRA-validated peak4000 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16900 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:197124217-197125416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16901 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene HECW2 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia. Szoltysek K, et al. Int J Mol Sci, 2020 Oct 16. PMID 33081245, Free PMC Article
  2. Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development. Gatzka M, et al. J Immunol, 2009 Jul 1. PMID 19542440, Free PMC Article
  3. DRAK2 participates in a negative feedback loop to control TGF-β/Smads signaling by binding to type I TGF-β receptor. Yang KM, et al. Cell Rep, 2012 Nov 29. PMID 23122956
  4. DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser(56) to diminish pancreatic β cell function upon overnutrition. Lu Y, et al. Sci Transl Med, 2024 Feb 7. PMID 38324636
  5. Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes. Friedrich ML, et al. J Biol Chem, 2007 Feb 16. PMID 17182616

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser[56] to diminish pancreatic beta cell function upon overnutrition.
    Title: DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser(56) to diminish pancreatic β cell function upon overnutrition.
  2. DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
    Title: DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
  3. DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia.
    Title: DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia.
  4. STK17B promotes carcinogenesis and metastasis via AKT/GSK-3beta/Snail signaling in hepatocellular carcinoma.
    Title: STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma.
  5. A significant interaction between variants in STK17B and PAX8, in papillary thyroid cancer susceptibility, is reported.
    Title: An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.
  6. ChIP assays showed that in U937 cells MYB binds to a conserved element upstream of the DRAK2 transcription start site.
    Title: The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression.
  7. DRAK2 protein directly binds to the type I TGF-beta receptor and Knockdown of DRAK2 suppresses the tumorigenic ability of breast cancer cells.
    Title: DRAK2 participates in a negative feedback loop to control TGF-β/Smads signaling by binding to type I TGF-β receptor.
  8. DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation.
    Title: Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Flemming body IDA
Inferred from Direct Assay
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 17B
Names
DAP kinase-related apoptosis-inducing protein kinase 2
death-associated protein kinase-related 2
NP_004217.1
XP_011510471.1
XP_011510472.1
XP_011510473.1
XP_047302289.1
XP_047302290.1
XP_047302291.1
XP_054200533.1
XP_054200534.1
XP_054200535.1
XP_054200536.1
XP_054200537.1
XP_054200538.1
XP_054200539.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004226.4 → NP_004217.1  serine/threonine-protein kinase 17B

    See identical proteins and their annotated locations for NP_004217.1

    Status: VALIDATED

    Source sequence(s)
    AC114760, BM994696
    Consensus CDS
    CCDS2315.1
    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7, Q6FG98
    Related
    ENSP00000263955.4, ENST00000263955.9
    Conserved Domains (1) summary
    cd14198
    Location:24 → 293
    STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    196133583..196176483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512169.2 → XP_011510471.1  serine/threonine-protein kinase 17B isoform X1

    See identical proteins and their annotated locations for XP_011510471.1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7, Q6FG98
    Related
    ENSP00000386853.1, ENST00000409228.5
    Conserved Domains (1) summary
    cd14198
    Location:24 → 293
    STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

  2. XM_011512170.2 → XP_011510472.1  serine/threonine-protein kinase 17B isoform X1

    See identical proteins and their annotated locations for XP_011510472.1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7, Q6FG98
    Related
    ENSP00000399755.2, ENST00000420683.2
    Conserved Domains (1) summary
    cd14198
    Location:24 → 293
    STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

  3. XM_047446334.1 → XP_047302290.1  serine/threonine-protein kinase 17B isoform X1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7

  4. XM_047446333.1 → XP_047302289.1  serine/threonine-protein kinase 17B isoform X1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7
    Related
    ENSP00000413289.2, ENST00000449152.2

  5. XM_011512171.3 → XP_011510473.1  serine/threonine-protein kinase 17B isoform X2

    See identical proteins and their annotated locations for XP_011510473.1

    Conserved Domains (2) summary
    smart00220
    Location:3 → 165
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 165
    PKc_like; Protein Kinases, catalytic domain

  6. XM_047446335.1 → XP_047302291.1  serine/threonine-protein kinase 17B isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    196617655..196666801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344561.1 → XP_054200536.1  serine/threonine-protein kinase 17B isoform X1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7

  2. XM_054344559.1 → XP_054200534.1  serine/threonine-protein kinase 17B isoform X1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7

  3. XM_054344560.1 → XP_054200535.1  serine/threonine-protein kinase 17B isoform X1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7

  4. XM_054344562.1 → XP_054200537.1  serine/threonine-protein kinase 17B isoform X1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7

  5. XM_054344558.1 → XP_054200533.1  serine/threonine-protein kinase 17B isoform X1

    UniProtKB/Swiss-Prot
    O94768
    UniProtKB/TrEMBL
    Q53QE7

  6. XM_054344563.1 → XP_054200538.1  serine/threonine-protein kinase 17B isoform X2

  7. XM_054344564.1 → XP_054200539.1  serine/threonine-protein kinase 17B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94768.1 GenPept UniProtKB/Swiss-Prot:O94768

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