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Cdc23 cell division cycle 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291689, updated on 9-Dec-2024

Summary

Official Symbol
Cdc23provided by RGD
Official Full Name
cell division cycle 23provided by RGD
Primary source
RGD:1304819
See related
EnsemblRapid:ENSRNOG00000024241 AllianceGenome:RGD:1304819
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be part of anaphase-promoting complex. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 179.6), Spleen (RPKM 133.3) and 9 other tissues See more
Orthologs
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Genomic context

See Cdc23 in Genome Data Viewer
Location:
18p12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26511019..26534872, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26236891..26260611, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27430924..27452569, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482927 Neighboring gene NME/NM23 family member 5 Neighboring gene bromodomain containing 8 Neighboring gene kinesin family member 20A Neighboring gene GDNF family receptor alpha 3 Neighboring gene cell division cycle 25C Neighboring gene stem-loop binding protein like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
part_of anaphase-promoting complex  
part_of anaphase-promoting complex  

General protein information

Preferred Names
cell division cycle protein 23 homolog
Names
CDC23 (cell division cycle 23, yeast, homolog)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100659.1NP_001094129.1  cell division cycle protein 23 homolog

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    F1LRQ6
    Related
    ENSRNOP00000089789.2, ENSRNOT00000101231.2
    Conserved Domains (3) summary
    COG0457
    Location:216451
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:367393
    TPR; TPR repeat [structural motif]
    pfam04049
    Location:45148
    ANAPC8; Anaphase promoting complex subunit 8 / Cdc23

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    26511019..26534872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277222.1XP_063133292.1  cell division cycle protein 23 homolog isoform X1

    UniProtKB/TrEMBL
    F1LRQ6
  2. XM_008772028.4XP_008770250.1  cell division cycle protein 23 homolog isoform X2

    See identical proteins and their annotated locations for XP_008770250.1

    UniProtKB/TrEMBL
    A0A8I5ZTG0, A6J2V5, F1LRQ6
    Related
    ENSRNOP00000082129.1, ENSRNOT00000110937.2
    Conserved Domains (5) summary
    COG0457
    Location:212399
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:367393
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:331364
    TPR_1; Tetratricopeptide repeat
    pfam04049
    Location:28154
    ANAPC8; Anaphase promoting complex subunit 8 / Cdc23
    pfam13414
    Location:367430
    TPR_11; TPR repeat

RNA

  1. XR_010059562.1 RNA Sequence

  2. XR_010059563.1 RNA Sequence

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