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Items: 1 to 20 of 241

1.
Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis
Brian Kleiboeker, Anyuan He, Min Tan, Dongliang Lu, Donghua Hu, Xuejing Liu, Parniyan Goodarzi, Fong-Fu Hsu, Babak Razani, Clay F. Semenkovich, Irfan J. Lodhi
Mol Metab. 2024 Apr; 82: 101913. Published online 2024 Mar 7. doi: 10.1016/j.molmet.2024.101913
PMCID:
PMC10950804
AbstractArticlePDF–4.3M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages
Ruiyi Zhang, Yifei Dong, Yang Liu, Dorsa Moezzi, Samira Ghorbani, Reza Mirzaei, Brian M Lozinski, Jeff F Dunn, V Wee Yong, Mengzhou Xue
Stroke Vasc Neurol. 2023 Dec; 8(6): 486–502. Published online 2023 May 3. doi: 10.1136/svn-2023-002331
PMCID:
PMC10800269
AbstractArticlePDF–9.0M
4.
Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1
Jiyeon Kim, Haeseung Lee, Jeong-Eun Lee, Garam Choi, Hayeon Chung, Daehong Kim, Min Jung Park, Yong Seok Gye, Kwang-Soo Shin, Chang-Yuil Kang, Seung-Ki Kwok, Yeonseok Chung
Proc Natl Acad Sci U S A. 2023 Feb 28; 120(9): e2213793120. Published online 2023 Feb 21. doi: 10.1073/pnas.2213793120
PMCID:
PMC9992818
AbstractArticlePDF–1.1M
5.
Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages
Suzanne A.E. van Wouw, Marlene van den Berg, Maroua El Ouraoui, Amber Meurs, Jenina Kingma, Roelof Ottenhoff, Melanie Loix, Marten A. Hoeksema, Koen Prange, Gerard Pasterkamp, Jerome J.A. Hendriks, Jeroen F.J. Bogie, Jan B. van Klinken, Frederic M. Vaz, Aldo Jongejan, Menno P.J. de Winther, Noam Zelcer
J Lipid Res. 2023 Feb; 64(2): 100325. Published online 2022 Dec 31. doi: 10.1016/j.jlr.2022.100325
PMCID:
PMC9926310
AbstractArticlePDF–2.6M
6.
Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor
Jean Personnaz, Enzo Piccolo, Alizée Dortignac, Jason S. Iacovoni, Jérôme Mariette, Vincent Rocher, Arnaud Polizzi, Aurélie Batut, Simon Deleruyelle, Lucas Bourdens, Océane Delos, Lucie Combes-Soia, Romain Paccoud, Elsa Moreau, Frédéric Martins, Thomas Clouaire, Fadila Benhamed, Alexandra Montagner, Walter Wahli, Robert F. Schwabe, Armelle Yart, Isabelle Castan-Laurell, Justine Bertrand-Michel, Odile Burlet-Schiltz, Catherine Postic, Pierre-Damien Denechaud, Cédric Moro, Gaelle Legube, Chih-Hao Lee, Hervé Guillou, Philippe Valet, Cédric Dray, Jean-Philippe Pradère
Sci Adv. 2022 Mar; 8(12): eabg9055. Published online 2022 Mar 25. doi: 10.1126/sciadv.abg9055
PMCID:
PMC8956270
AbstractArticlePDF–3.7M
7.
Krüppel-like factor 14 deletion in myeloid cells accelerates atherosclerotic lesion development
Huilun Wang, Yanhong Guo, Haocheng Lu, Yonghong Luo, Wenting Hu, Wenying Liang, Minerva T Garcia-Barrio, Lin Chang, Anna Schwendeman, Jifeng Zhang, Y Eugene Chen
Cardiovasc Res. 2022 Feb; 118(2): 475–488. Published online 2021 Feb 4. doi: 10.1093/cvr/cvab027
PMCID:
PMC8803076
AbstractArticlePDF–2.1M
8.
Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice
Kaori Endo-Umeda, Hiroyuki Nakashima, Shigeyuki Uno, Shota Toyoshima, Naoki Umeda, Shihoko Komine-Aizawa, Shuhji Seki, Makoto Makishima
Sci Rep. 2021; 11: 22595. Published online 2021 Nov 19. doi: 10.1038/s41598-021-02062-z
PMCID:
PMC8604965
AbstractArticlePDF–4.8M
9.
SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1
Chaoyu Zhu, Menghao Huang, Hyeong-Geug Kim, Kushan Chowdhury, Jing Gao, Sheng Liu, Jun Wan, Li Wei, X. Charlie Dong
Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2022 Dec 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1; 1867(12): 166249. Published online 2021 Aug 21. doi: 10.1016/j.bbadis.2021.166249
PMCID:
PMC8488016
AbstractArticlePDF–1.4M
10.
Myeloid-Derived Suppressive Cells Deficient in Liver X Receptor α Protected From Autoimmune Hepatitis
Bo Li, Min Lian, Yikang Li, Qiwei Qian, Jun Zhang, Qiaoyan Liu, Ruqi Tang, Xiong Ma
Front Immunol. 2021; 12: 732102. Published online 2021 Aug 26. doi: 10.3389/fimmu.2021.732102
PMCID:
PMC8427166
AbstractArticlePDF–5.5M
11.
Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα
Jessica Kain, Xiaolong Wei, Nihal A. Reddy, Andrew J. Price, Claire Woods, Irina M. Bochkis
Mol Metab. 2021 Nov; 53: 101291. Published online 2021 Jul 8. doi: 10.1016/j.molmet.2021.101291
PMCID:
PMC8350412
AbstractArticlePDF–6.8M
12.
Liver X receptor β is required for the survival of single-positive thymocytes by regulating IL-7Rα expression
Huang Huang, Xiaoping Wu, Dongwei Meng, Yizhou Feng, Lan Zhou, Zhenyu Liu, Shupei Tang, Xueqin Li, Yi Cao, Haiyang He, Zhunyi Xie, Jingbo Zhang, Yongwen Chen, Tingting Zhao, Yuzhang Wu, Xinyuan Zhou
Cell Mol Immunol. 2021 Aug; 18(8): 1969–1980. Published online 2020 Sep 22. doi: 10.1038/s41423-020-00546-y
PMCID:
PMC8322414
AbstractArticlePDF–2.2M
13.
Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation
Takuya Ishikiriyama, Hiroyuki Nakashima, Kaori Endo-Umeda, Masahiro Nakashima, Seigo Ito, Manabu Kinoshita, Masami Ikarashi, Makoto Makishima, Shuhji Seki
PLoS One. 2021; 16(7): e0254886. Published online 2021 Jul 23. doi: 10.1371/journal.pone.0254886
PMCID:
PMC8301620
AbstractArticlePDF–1.9M
14.
Crosstalk Between LXR and Caveolin-1 Signaling Supports Cholesterol Efflux and Anti-Inflammatory Pathways in Macrophages
Cristina M. Ramírez, Marta Torrecilla-Parra, Virginia Pardo-Marqués, Mario Fernández de-Frutos, Ana Pérez-García, Carlos Tabraue, Juan Vladimir de la Rosa, Patricia Martín-Rodriguez, Mercedes Díaz-Sarmiento, Uxue Nuñez, Marta C. Orizaola, Paqui G. Través, Marta Camps, Lisardo Boscá, Antonio Castrillo
Front Endocrinol (Lausanne) 2021; 12: 635923. Published online 2021 May 27. doi: 10.3389/fendo.2021.635923
PMCID:
PMC8190384
AbstractArticlePDF–10M
15.
Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice
Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A. Nikain, Tatjana Josefs, Mélanie Mahé, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela L. Garabedian, Chris Zoumadakis, Chi Yun, Bara Badwan, Emily J. Brown, Adam C. Mar, Robert J. Schneider, Ira J. Goldberg, Inés Pineda-Torra, Edward A. Fisher, Michael J. Garabedian
Commun Biol. 2021; 4: 420. Published online 2021 Mar 26. doi: 10.1038/s42003-021-01925-5
PMCID:
PMC7997930
AbstractArticlePDF–6.8M
16.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
17.
Administration of GDF3 Into Septic Mice Improves Survival via Enhancing LXRα-Mediated Macrophage Phagocytosis
Peng Wang, Xingjiang Mu, Hongyan Zhao, Yutian Li, Lu Wang, Vivian Wolfe, Shu-Nan Cui, Xiaohong Wang, Tianqing Peng, Basilia Zingarelli, Chunting Wang, Guo-Chang Fan
Front Immunol. 2021; 12: 647070. Published online 2021 Feb 17. doi: 10.3389/fimmu.2021.647070
PMCID:
PMC7925632
AbstractArticlePDF–4.0M
18.
Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia
Laura Bousset, Amandine Septier, Julio Bunay, Allison Voisin, Rachel Guiton, Christelle Damon-Soubeyrant, Yoan Renaud, Angélique De Haze, Vincent Sapin, Anne Fogli, Amandine Rambur, Cyrille De Joussineau, Ayhan Kocer, Amalia Trousson, Joëlle Henry-Berger, Marcus Höring, Gerhard Liebisch, Silke Matysik, Jean-Marc A. Lobaccaro, Laurent Morel, Silvère Baron
PLoS Biol. 2020 Dec; 18(12): e3000948. Published online 2020 Dec 7. doi: 10.1371/journal.pbio.3000948
PMCID:
PMC7752095
AbstractArticlePDF–4.1M
19.
Liver X Receptors Protect Dorsal Root Ganglia from Obesity-Induced Endoplasmic Reticulum Stress and Mechanical Allodynia
Chaitanya K. Gavini, Angie L. Bookout, Raiza Bonomo, Laurent Gautron, Syann Lee, Virginie Mansuy-Aubert
Cell Rep. Author manuscript; available in PMC 2020 Dec 11.
Published in final edited form as: Cell Rep. 2018 Oct 9; 25(2): 271–277.e4. doi: 10.1016/j.celrep.2018.09.046
PMCID:
PMC7732131
AbstractArticlePDF–1.6M
20.
Liver X receptors are required for thymic resilience and T cell output
Christopher T. Chan, Ashley M. Fenn, Nina K. Harder, John E. Mindur, Cameron S. McAlpine, Jyoti Patel, Colin Valet, Sara Rattik, Yoshiko Iwamoto, Shun He, Atsushi Anzai, Florian Kahles, Wolfram C. Poller, Henrike Janssen, Lai Ping Wong, Carlos Fernandez-Hernando, David R. Koolbergen, Anja M. van der Laan, Laurent Yvan-Charvet, Ruslan I. Sadreyev, Matthias Nahrendorf, Marit Westerterp, Alan R. Tall, Jan-Ake Gustafsson, Filip K. Swirski
J Exp Med. 2020 Oct 5; 217(10): e20200318. Published online 2020 Jul 27. doi: 10.1084/jem.20200318
PMCID:
PMC7537384
AbstractArticlePDF–7.5M

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