PMC Links for Gene (Select 9536) - PMC

Anna Kock, Karin Larsson, Filip Bergqvist, Nina Eissler, Lotta H.M. Elfman, Joan Raouf, Marina Korotkova, John Inge Johnsen, Per-Johan Jakobsson, Per Kogner

EBioMedicine. 2018 Jun; 32: 84–92. Published online 2018 May 24. doi: 10.1016/j.ebiom.2018.05.008

PMCID:: PMC6021299

Abstract Article PDF–4.1M

Select item 60011244.

Down-regulation of microsomal prostaglandin E2 synthase-1 in the infrapatellar fat pad of osteoarthritis patients with hypercholesterolemia

Manabu Mukai, Kentaro Uchida, Shotaro Takano, Dai Iwase, Jun Aikawa, Gen Inoue, Masayuki Miyagi, Masashi Takaso

Lipids Health Dis. 2018; 17: 137. Published online 2018 Jun 13. doi: 10.1186/s12944-018-0792-7

PMCID:: PMC6001124

Abstract Article PDF–484K

Select item 56600065.

Inhibition of microsomal PGE synthase‐1 reduces human vascular tone by increasing PGI₂: a safer alternative to COX‐2 inhibition

Gulsev Ozen, Ingrid Gomez, Armond Daci, Catherine Deschildre, Lilia Boubaya, Onder Teskin, B Sonmez Uydeş‐Doğan, Per‐Johan Jakobsson, Dan Longrois, Gokce Topal, Xavier Norel

Br J Pharmacol. 2017 Nov; 174(22): 4087–4098. Published online 2017 Aug 11. doi: 10.1111/bph.13939

PMCID:: PMC5660006

Abstract Article PDF–1.3M

Select item 53784226.

Identification of Four Novel Loci in Asthma in European American and African American Populations

Berta Almoguera, Lyam Vazquez, Frank Mentch, John Connolly, Jennifer A. Pacheco, Agnes S. Sundaresan, Peggy L. Peissig, James G. Linneman, Catherine A. McCarty, David Crosslin, David S. Carrell, Todd Lingren, Bahram Namjou-Khales, John B. Harley, Eric Larson, Gail P. Jarvik, Murray Brilliant, Marc S. Williams, Iftikhar J. Kullo, Erik B. Hysinger, Patrick M. A. Sleiman, Hakon Hakonarson

Am J Respir Crit Care Med. 2017 Feb 15; 195(4): 456–463. Published online 2017 Feb 15. doi: 10.1164/rccm.201604-0861OC

PMCID:: PMC5378422

Abstract Article PDF–671K

Select item 49802647.

Microsomal Prostaglandin E Synthase-1 Expression by Aortic Smooth Muscle Cells Attenuates the Differentiated Phenotype

Oreoluwa O. Adedoyin, Charles D. Loftin

J Cardiovasc Pharmacol. Author manuscript; available in PMC 2017 Aug 1.

Published in final edited form as: J Cardiovasc Pharmacol. 2016 Aug; 68(2): 127–142. doi: 10.1097/FJC.0000000000000395

PMCID:: PMC4980264

Abstract Article PDF–1006K

Select item 48400878.

Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression

Sun-Hee Kim, Yuuri Hashimoto, Sung-Nam Cho, Jason Roszik, Denái R. Milton, Fulya Dal, Sangwon F. Kim, David G. Menter, Peiying Yang, Suhendan Ekmekcioglu, Elizabeth A. Grimm

Pigment Cell Melanoma Res. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: Pigment Cell Melanoma Res. 2016 May; 29(3): 297–308. Published online 2016 Mar 15. doi: 10.1111/pcmr.12455

PMCID:: PMC4840087

Abstract Article PDF–1.4M

Select item 45267959.

mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity

Federica Finetti, Erika Terzuoli, Antonio Giachetti, Raffaella Santi, Donata Villari, Hiromi Hanaka, Olof Radmark, Marina Ziche, Sandra Donnini

Endocr Relat Cancer. 2015 Aug; 22(4): 665–678. Prepublished online 2015 Jun 25. doi: 10.1530/ERC-15-0277

PMCID:: PMC4526795

Abstract Article PDF–581K

Select item 452344410.

Instability of a dinucleotide repeat in the 3′‐untranslated region (UTR) of the microsomal prostaglandin E synthase‐1 (mPGES‐1) gene in microsatellite instability‐high (MSI‐H) colorectal carcinoma

Durga Prasad Cherukuri, Joshua L. Deignan, Kingshuk Das, Wayne W. Grody, Harvey Herschman

Mol Oncol. 2015 Aug; 9(7): 1252–1258. Published online 2015 Mar 5. doi: 10.1016/j.molonc.2015.01.009

PMCID:: PMC4523444

Abstract Article PDF–961K

Select item 352338911.

Carnosol and Carnosic Acids from Salvia officinalis Inhibit Microsomal Prostaglandin E₂ Synthase-1

Julia Bauer, Susanne Kuehnl, Judith M. Rollinger, Olga Scherer, Hinnak Northoff, Hermann Stuppner, Oliver Werz, Andreas Koeberle

J Pharmacol Exp Ther. Author manuscript; available in PMC 2012 Dec 17.

Published in final edited form as: J Pharmacol Exp Ther. 2012 Jul; 342(1): 169–176. Published online 2012 Apr 16. doi: 10.1124/jpet.112.193847

PMCID:: PMC3523389

Abstract Article PDF–341K

Select item 324493912.

Location of Inhibitor Binding Sites in the Human Inducible Prostaglandin E Synthase, MPGES1

Edward B. Prage, Sven-Christian Pawelzik, Laura S. Busenlehner, Kwangho Kim, Ralf Morgenstern, Per-Johan Jakobsson, Richard N. Armstrong

Biochemistry. Author manuscript; available in PMC 2012 Sep 6.

Published in final edited form as: Biochemistry. 2011 Sep 6; 50(35): 7684–7693. Published online 2011 Aug 9. doi: 10.1021/bi2010448

PMCID:: PMC3244939

Abstract Article PDF–2.0M

Select item 317293113.

Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis

Marina Korotkova, Nina A Daha, Maria Seddighzadeh, Bo Ding, Anca I Catrina, Staffan Lindblad, Tom W J Huizinga, Rene E M Toes, Lars Alfredsson, Lars Klareskog, Per-Johan Jakobsson, Leonid Padyukov

Eur J Hum Genet. 2011 Aug; 19(8): 908–914. Published online 2011 Mar 30. doi: 10.1038/ejhg.2011.50

PMCID:: PMC3172931

Abstract Article PDF–543K

Select item 295525514.

mPGES-1 expression in non-cancerous liver tissue impacts on postoperative recurrence of HCC

Koichi Nonaka, Hikaru Fujioka, Yasushi Takii, Seigo Abiru, Kiyoshi Migita, Masahiro Ito, Takashi Kanematsu, Hiromi Ishibashi

World J Gastroenterol. 2010 Oct 14; 16(38): 4846–4853. Published online 2010 Oct 14. doi: 10.3748/wjg.v16.i38.4846

PMCID:: PMC2955255

Abstract Article PDF–924K

Select item 293795715.

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1

Sven-Christian Pawelzik, Narasimha Rao Uda, Linda Spahiu, Caroline Jegerschöld, Patric Stenberg, Hans Hebert, Ralf Morgenstern, Per-Johan Jakobsson

J Biol Chem. 2010 Sep 17; 285(38): 29254–29261. Published online 2010 Jul 6. doi: 10.1074/jbc.M110.114454

PMCID:: PMC2937957

Abstract Article PDF–2.0M

Select item 287959816.

Understanding Microscopic Binding of Human Microsomal Prostaglandin E Synthase-1 (mPGES-1) Trimer with Substrate PGH₂ and Cofactor GSH: Insights from Computational Alanine Scanning and Site-directed Mutagenesis

Adel Hamza, Min Tong, Mohamed Diwan M. AbdulHameed, Junjun Liu, Alan C. Goren, Hsin-Hsiung Tai, Chang-Guo Zhan

J Phys Chem B. Author manuscript; available in PMC 2011 Apr 29.

Published in final edited form as: J Phys Chem B. 2010 Apr 29; 114(16): 5605–5616. doi: 10.1021/jp100668y

PMCID:: PMC2879598

Abstract Article PDF–1.3M

Select item 283254817.

Hypoxia activates the cyclooxygenase-2–prostaglandin E synthase axis

James J. Lee, Mitsuteru Natsuizaka, Shinya Ohashi, Gabrielle S. Wong, Munenori Takaoka, Carmen Z. Michaylira, Daniela Budo, John W. Tobias, Michiyuki Kanai, Yasuhiro Shirakawa, Yoshio Naomoto, Andres J.P. Klein-Szanto, Volker H. Haase, Hiroshi Nakagawa

Carcinogenesis. 2010 Mar; 31(3): 427–434. Published online 2009 Dec 30. doi: 10.1093/carcin/bgp326

PMCID:: PMC2832548

Abstract Article PDF–644K

Select item 276858918.

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells

Hiromi Hanaka, Sven-Christian Pawelzik, John Inge Johnsen, Marija Rakonjac, Kan Terawaki, Agnes Rasmuson, Baldur Sveinbjörnsson, Martin C. Schumacher, Mats Hamberg, Bengt Samuelsson, Per-Johan Jakobsson, Per Kogner, Olof Rådmark

Proc Natl Acad Sci U S A. 2009 Nov 3; 106(44): 18757–18762. Published online 2009 Oct 21. doi: 10.1073/pnas.0910218106

PMCID:: PMC2768589

Abstract Article PDF–1.0M

Select item 261051119.

Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H₂ into Prostaglandin F_2α

Tove Hammarberg, Mats Hamberg, Anders Wetterholm, Henrik Hansson, Bengt Samuelsson, Jesper Z. Haeggström

J Biol Chem. 2009 Jan 2; 284(1): 301–305. doi: 10.1074/jbc.M808365200

PMCID:: PMC2610511

Abstract Article PDF–361K

Select item 250020720.

Elevated microsomal prostaglandin-E synthase–1 in Alzheimer's disease

Uzma A. Chaudhry, Hean Zhuang, Barbara J. Crain, Sylvain Doré

Alzheimers Dement. Author manuscript; available in PMC 2009 Jan 1.

Published in final edited form as: Alzheimers Dement. 2008 Jan; 4(1): 6–13. Published online 2007 Dec 21. doi: 10.1016/j.jalz.2007.10.015

PMCID:: PMC2500207

Abstract Article PDF–1.1M

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