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RecName: Full=Homeobox protein Hox-A1a; Short=Hox-A1

UniProtKB/Swiss-Prot: Q98SI1.1

Identical Proteins FASTA Graphics 

LOCUS       HXA1A_DANRE              329 aa            linear   VRT 27-NOV-2024
DEFINITION  RecName: Full=Homeobox protein Hox-A1a; Short=Hox-A1.
ACCESSION   Q98SI1
VERSION     Q98SI1.1
DBSOURCE    UniProtKB: locus HXA1A_DANRE, accession Q98SI1;
            class: standard.
            extra accessions:Q1L968,Q4PRB2,Q8AWZ1,Q98SI0,Q9YGT8
            created: Feb 1, 2005.
            sequence updated: Jun 1, 2001.
            annotation updated: Nov 27, 2024.
            xrefs: AJ306430.1, CAC34565.1, AJ306431.1, CAC34566.1, AF071243.1,
            AAD15937.1, AL645756.6, CAD52136.1, CAD52137.1, CR382300.12,
            CAK10852.1, DQ060531.1, AAY67909.1, NP_571611.1, XP_017207752.1
            xrefs (non-sequence databases): AlphaFoldDB:Q98SI1, SMR:Q98SI1,
            STRING:7955.ENSDARP00000133272, PaxDb:7955-ENSDARP00000074910,
            Ensembl:ENSDART00000167757, Ensembl:ENSDARP00000133272,
            Ensembl:ENSDARG00000104307, GeneID:58051, KEGG:dre:58051,
            AGR:ZFIN:ZDB-GENE-000823-5, CTD:58051, ZFIN:ZDB-GENE-000823-5,
            eggNOG:KOG0489, InParanoid:Q98SI1, OMA:SAQTFDW,
            OrthoDB:728401at2759, PhylomeDB:Q98SI1, TreeFam:TF317730,
            PRO:PR:Q98SI1, Proteomes:UP000000437, Bgee:ENSDARG00000104307,
            ExpressionAtlas:Q98SI1, GO:0005634, GO:0000981, GO:0000978,
            GO:0006357, GO:0003187, CDD:cd00086, FunFam:1.10.10.60:FF:000113,
            Gene3D:1.10.10.60, InterPro:IPR001356, InterPro:IPR020479,
            InterPro:IPR017970, InterPro:IPR009057, InterPro:IPR046327,
            PANTHER:PTHR45946:SF3, PANTHER:PTHR45946, Pfam:PF00046,
            PRINTS:PR00024, SMART:SM00389, SUPFAM:SSF46689, PROSITE:PS00027,
            PROSITE:PS50071
KEYWORDS    Alternative splicing; Developmental protein; DNA-binding; Homeobox;
            Nucleus; Reference proteome; Transcription; Transcription
            regulation.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 329)
  AUTHORS   McClintock,J.M., Carlson,R., Mann,D.M. and Prince,V.E.
  TITLE     Consequences of Hox gene duplication in the vertebrates: an
            investigation of the zebrafish Hox paralogue group 1 genes
  JOURNAL   Development 128 (13), 2471-2484 (2001)
   PUBMED   11493564
  REMARK    NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
REFERENCE   2  (residues 1 to 329)
  AUTHORS   Amores,A., Force,A., Yan,Y.L., Joly,L., Amemiya,C., Fritz,A.,
            Ho,R.K., Langeland,J., Prince,V., Wang,Y.L., Westerfield,M.,
            Ekker,M. and Postlethwait,J.H.
  TITLE     Zebrafish hox clusters and vertebrate genome evolution
  JOURNAL   Science 282 (5394), 1711-1714 (1998)
   PUBMED   9831563
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA].
REFERENCE   3  (residues 1 to 329)
  AUTHORS   Howe,K., Clark,M.D., Torroja,C.F., Torrance,J., Berthelot,C.,
            Muffato,M., Collins,J.E., Humphray,S., McLaren,K., Matthews,L.,
            McLaren,S., Sealy,I., Caccamo,M., Churcher,C., Scott,C.,
            Barrett,J.C., Koch,R., Rauch,G.J., White,S., Chow,W., Kilian,B.,
            Quintais,L.T., Guerra-Assuncao,J.A., Zhou,Y., Gu,Y., Yen,J.,
            Vogel,J.H., Eyre,T., Redmond,S., Banerjee,R., Chi,J., Fu,B.,
            Langley,E., Maguire,S.F., Laird,G.K., Lloyd,D., Kenyon,E.,
            Donaldson,S., Sehra,H., Almeida-King,J., Loveland,J., Trevanion,S.,
            Jones,M., Quail,M., Willey,D., Hunt,A., Burton,J., Sims,S.,
            McLay,K., Plumb,B., Davis,J., Clee,C., Oliver,K., Clark,R.,
            Riddle,C., Elliot,D., Threadgold,G., Harden,G., Ware,D., Begum,S.,
            Mortimore,B., Kerry,G., Heath,P., Phillimore,B., Tracey,A.,
            Corby,N., Dunn,M., Johnson,C., Wood,J., Clark,S., Pelan,S.,
            Griffiths,G., Smith,M., Glithero,R., Howden,P., Barker,N.,
            Lloyd,C., Stevens,C., Harley,J., Holt,K., Panagiotidis,G.,
            Lovell,J., Beasley,H., Henderson,C., Gordon,D., Auger,K.,
            Wright,D., Collins,J., Raisen,C., Dyer,L., Leung,K., Robertson,L.,
            Ambridge,K., Leongamornlert,D., McGuire,S., Gilderthorp,R.,
            Griffiths,C., Manthravadi,D., Nichol,S., Barker,G., Whitehead,S.,
            Kay,M., Brown,J., Murnane,C., Gray,E., Humphries,M., Sycamore,N.,
            Barker,D., Saunders,D., Wallis,J., Babbage,A., Hammond,S.,
            Mashreghi-Mohammadi,M., Barr,L., Martin,S., Wray,P., Ellington,A.,
            Matthews,N., Ellwood,M., Woodmansey,R., Clark,G., Cooper,J.,
            Tromans,A., Grafham,D., Skuce,C., Pandian,R., Andrews,R.,
            Harrison,E., Kimberley,A., Garnett,J., Fosker,N., Hall,R.,
            Garner,P., Kelly,D., Bird,C., Palmer,S., Gehring,I., Berger,A.,
            Dooley,C.M., Ersan-Urun,Z., Eser,C., Geiger,H., Geisler,M.,
            Karotki,L., Kirn,A., Konantz,J., Konantz,M., Oberlander,M.,
            Rudolph-Geiger,S., Teucke,M., Lanz,C., Raddatz,G., Osoegawa,K.,
            Zhu,B., Rapp,A., Widaa,S., Langford,C., Yang,F., Schuster,S.C.,
            Carter,N.P., Harrow,J., Ning,Z., Herrero,J., Searle,S.M.,
            Enright,A., Geisler,R., Plasterk,R.H., Lee,C., Westerfield,M., de
            Jong,P.J., Zon,L.I., Postlethwait,J.H., Nusslein-Volhard,C.,
            Hubbard,T.J., Roest Crollius,H., Rogers,J. and Stemple,D.L.
  TITLE     The zebrafish reference genome sequence and its relationship to the
            human genome
  JOURNAL   Nature 496 (7446), 498-503 (2013)
   PUBMED   23594743
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=Tuebingen
            Erratum:[Nature. 2014 Jan 9;505(7482):248. Cooper, James [corrected
            to Cooper, James D]; Eliott, David [corrected to Elliot, David];
            Mortimer, Beverly [corrected to Mortimore, Beverley]; Begum,
            Sharmin [added]; Lloyd, Christine [added]; Lanz, Christa [added];
            Raddatz, Gunter [added]; Schuster, Ste]
REFERENCE   4  (residues 1 to 329)
  AUTHORS   Corredor-Adamez,M., Welten,M.C., Spaink,H.P., Jeffery,J.E.,
            Schoon,R.T., de Bakker,M.A., Bagowski,C.P., Meijer,A.H.,
            Verbeek,F.J. and Richardson,M.K.
  TITLE     Genomic annotation and transcriptome analysis of the zebrafish
            (Danio rerio) hox complex with description of a novel member, hox b
            13a
  JOURNAL   Evol Dev 7 (5), 362-375 (2005)
   PUBMED   16174031
  REMARK    NUCLEOTIDE SEQUENCE [MRNA] OF 136-224.;
            STRAIN=Tuebingen
COMMENT     On Jul 11, 2006 this sequence version replaced gi:82249195.
            [FUNCTION] Sequence-specific transcription factor. Part of a
            developmental regulatory system that provides cells with specific
            positional identities on the anterior-posterior axis (By
            similarity). {ECO:0000250|UniProtKB:Q90423}.
            [SUBCELLULAR LOCATION] Nucleus
            {ECO:0000255|PROSITE-ProRule:PRU00108}.
            [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
            isoforms=2; Name=1; IsoId=Q98SI1-1; Sequence=Displayed; Name=2;
            IsoId=Q98SI1-2; Sequence=VSP_012678.
            [SIMILARITY] Belongs to the Antp homeobox family. Labial subfamily.
            {ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Danio rerio"
                     /db_xref="taxon:7955"
     gene            1..329
                     /gene="hoxa1a"
                     /gene_synonym="hoxa1"
     Protein         1..329
                     /product="Homeobox protein Hox-A1a"
                     /note="Hox-A1"
                     /UniProtKB_evidence="Evidence at transcript level"
     Region          1..329
                     /region_name="Mature chain"
                     /note="Homeobox protein Hox-A1a. /id=PRO_0000200033."
     Region          1..28
                     /region_name="Conflict"
                     /note="MSTFLDFSSISGGGDGGSGGSCSVRAFH -> MEVAGARAQSGRSQ (in
                     Ref. 2). /evidence=ECO:0000305."
     Region          158..192
                     /region_name="Splicing variant"
                     /note="Missing (in isoform 2).
                     /evidence=ECO:0000303|PubMed:11493564. /id=VSP_012678."
     Region          200..205
                     /region_name="Short sequence motif of biological interest"
                     /note="Antp-type hexapeptide."
     Region          208..227
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Site            225..284
                     /site_type="DNA binding"
                     /note="Homeobox.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00108."
     Region          229..282
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          277..329
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          279..308
                     /region_name="Compositionally biased region"
                     /note="Basic and acidic residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          296
                     /region_name="Conflict"
                     /note="Q -> E (in Ref. 1; CAC34566).
                     /evidence=ECO:0000305."
     Region          309..329
                     /region_name="Compositionally biased region"
                     /note="Polar residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN      
        1 mstfldfssi sgggdggsgg scsvrafhgd hglstfqssc avrlnscsgd erfmsnissq
       61 dvinsqpqqa gsyqspgtls itysahpsyg tqsfctgynh yalnqdvess vsfpqcgplv
      121 ysgnisstvv qhrhhrhgys sgnvhlhgqf qygsatygns sdqanltfva gcsnplsplh
      181 vphhdaccsp lsdgvptgqt fdwmkvkrnp pktgkageyg fggqpntvrt nfstkqltel
      241 ekefhfnkyl trarrveiaa slqlnetqvk iwfqnrrmkq kkrekegllp kslseqkdgl
      301 ektedaseks psapstpsps ptveayssn
//
1..329
/gene="hoxa1a"
/gene_synonym="hoxa1"
Feature Q98SI1 : 1 segment
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Reference sequence information

  • RefSeq protein
    See the reference protein sequence for homeobox protein Hox-A1a (NP_571611.1).

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