LOCUS HXA1A_DANRE 329 aa linear VRT 27-NOV-2024
DEFINITION RecName: Full=Homeobox protein Hox-A1a; Short=Hox-A1.
ACCESSION Q98SI1
VERSION Q98SI1.1
DBSOURCE UniProtKB: locus HXA1A_DANRE, accession Q98SI1;
class: standard.
extra accessions:Q1L968,Q4PRB2,Q8AWZ1,Q98SI0,Q9YGT8
created: Feb 1, 2005.
sequence updated: Jun 1, 2001.
annotation updated: Nov 27, 2024.
xrefs: AJ306430.1, CAC34565.1, AJ306431.1, CAC34566.1, AF071243.1,
AAD15937.1, AL645756.6, CAD52136.1, CAD52137.1, CR382300.12,
CAK10852.1, DQ060531.1, AAY67909.1, NP_571611.1, XP_017207752.1
xrefs (non-sequence databases): AlphaFoldDB:Q98SI1, SMR:Q98SI1,
STRING:7955.ENSDARP00000133272, PaxDb:7955-ENSDARP00000074910,
Ensembl:ENSDART00000167757, Ensembl:ENSDARP00000133272,
Ensembl:ENSDARG00000104307, GeneID:58051, KEGG:dre:58051,
AGR:ZFIN:ZDB-GENE-000823-5, CTD:58051, ZFIN:ZDB-GENE-000823-5,
eggNOG:KOG0489, InParanoid:Q98SI1, OMA:SAQTFDW,
OrthoDB:728401at2759, PhylomeDB:Q98SI1, TreeFam:TF317730,
PRO:PR:Q98SI1, Proteomes:UP000000437, Bgee:ENSDARG00000104307,
ExpressionAtlas:Q98SI1, GO:0005634, GO:0000981, GO:0000978,
GO:0006357, GO:0003187, CDD:cd00086, FunFam:1.10.10.60:FF:000113,
Gene3D:1.10.10.60, InterPro:IPR001356, InterPro:IPR020479,
InterPro:IPR017970, InterPro:IPR009057, InterPro:IPR046327,
PANTHER:PTHR45946:SF3, PANTHER:PTHR45946, Pfam:PF00046,
PRINTS:PR00024, SMART:SM00389, SUPFAM:SSF46689, PROSITE:PS00027,
PROSITE:PS50071
KEYWORDS Alternative splicing; Developmental protein; DNA-binding; Homeobox;
Nucleus; Reference proteome; Transcription; Transcription
regulation.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (residues 1 to 329)
AUTHORS McClintock,J.M., Carlson,R., Mann,D.M. and Prince,V.E.
TITLE Consequences of Hox gene duplication in the vertebrates: an
investigation of the zebrafish Hox paralogue group 1 genes
JOURNAL Development 128 (13), 2471-2484 (2001)
PUBMED 11493564
REMARK NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
REFERENCE 2 (residues 1 to 329)
AUTHORS Amores,A., Force,A., Yan,Y.L., Joly,L., Amemiya,C., Fritz,A.,
Ho,R.K., Langeland,J., Prince,V., Wang,Y.L., Westerfield,M.,
Ekker,M. and Postlethwait,J.H.
TITLE Zebrafish hox clusters and vertebrate genome evolution
JOURNAL Science 282 (5394), 1711-1714 (1998)
PUBMED 9831563
REMARK NUCLEOTIDE SEQUENCE [GENOMIC DNA].
REFERENCE 3 (residues 1 to 329)
AUTHORS Howe,K., Clark,M.D., Torroja,C.F., Torrance,J., Berthelot,C.,
Muffato,M., Collins,J.E., Humphray,S., McLaren,K., Matthews,L.,
McLaren,S., Sealy,I., Caccamo,M., Churcher,C., Scott,C.,
Barrett,J.C., Koch,R., Rauch,G.J., White,S., Chow,W., Kilian,B.,
Quintais,L.T., Guerra-Assuncao,J.A., Zhou,Y., Gu,Y., Yen,J.,
Vogel,J.H., Eyre,T., Redmond,S., Banerjee,R., Chi,J., Fu,B.,
Langley,E., Maguire,S.F., Laird,G.K., Lloyd,D., Kenyon,E.,
Donaldson,S., Sehra,H., Almeida-King,J., Loveland,J., Trevanion,S.,
Jones,M., Quail,M., Willey,D., Hunt,A., Burton,J., Sims,S.,
McLay,K., Plumb,B., Davis,J., Clee,C., Oliver,K., Clark,R.,
Riddle,C., Elliot,D., Threadgold,G., Harden,G., Ware,D., Begum,S.,
Mortimore,B., Kerry,G., Heath,P., Phillimore,B., Tracey,A.,
Corby,N., Dunn,M., Johnson,C., Wood,J., Clark,S., Pelan,S.,
Griffiths,G., Smith,M., Glithero,R., Howden,P., Barker,N.,
Lloyd,C., Stevens,C., Harley,J., Holt,K., Panagiotidis,G.,
Lovell,J., Beasley,H., Henderson,C., Gordon,D., Auger,K.,
Wright,D., Collins,J., Raisen,C., Dyer,L., Leung,K., Robertson,L.,
Ambridge,K., Leongamornlert,D., McGuire,S., Gilderthorp,R.,
Griffiths,C., Manthravadi,D., Nichol,S., Barker,G., Whitehead,S.,
Kay,M., Brown,J., Murnane,C., Gray,E., Humphries,M., Sycamore,N.,
Barker,D., Saunders,D., Wallis,J., Babbage,A., Hammond,S.,
Mashreghi-Mohammadi,M., Barr,L., Martin,S., Wray,P., Ellington,A.,
Matthews,N., Ellwood,M., Woodmansey,R., Clark,G., Cooper,J.,
Tromans,A., Grafham,D., Skuce,C., Pandian,R., Andrews,R.,
Harrison,E., Kimberley,A., Garnett,J., Fosker,N., Hall,R.,
Garner,P., Kelly,D., Bird,C., Palmer,S., Gehring,I., Berger,A.,
Dooley,C.M., Ersan-Urun,Z., Eser,C., Geiger,H., Geisler,M.,
Karotki,L., Kirn,A., Konantz,J., Konantz,M., Oberlander,M.,
Rudolph-Geiger,S., Teucke,M., Lanz,C., Raddatz,G., Osoegawa,K.,
Zhu,B., Rapp,A., Widaa,S., Langford,C., Yang,F., Schuster,S.C.,
Carter,N.P., Harrow,J., Ning,Z., Herrero,J., Searle,S.M.,
Enright,A., Geisler,R., Plasterk,R.H., Lee,C., Westerfield,M., de
Jong,P.J., Zon,L.I., Postlethwait,J.H., Nusslein-Volhard,C.,
Hubbard,T.J., Roest Crollius,H., Rogers,J. and Stemple,D.L.
TITLE The zebrafish reference genome sequence and its relationship to the
human genome
JOURNAL Nature 496 (7446), 498-503 (2013)
PUBMED 23594743
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=Tuebingen
Erratum:[Nature. 2014 Jan 9;505(7482):248. Cooper, James [corrected
to Cooper, James D]; Eliott, David [corrected to Elliot, David];
Mortimer, Beverly [corrected to Mortimore, Beverley]; Begum,
Sharmin [added]; Lloyd, Christine [added]; Lanz, Christa [added];
Raddatz, Gunter [added]; Schuster, Ste]
REFERENCE 4 (residues 1 to 329)
AUTHORS Corredor-Adamez,M., Welten,M.C., Spaink,H.P., Jeffery,J.E.,
Schoon,R.T., de Bakker,M.A., Bagowski,C.P., Meijer,A.H.,
Verbeek,F.J. and Richardson,M.K.
TITLE Genomic annotation and transcriptome analysis of the zebrafish
(Danio rerio) hox complex with description of a novel member, hox b
13a
JOURNAL Evol Dev 7 (5), 362-375 (2005)
PUBMED 16174031
REMARK NUCLEOTIDE SEQUENCE [MRNA] OF 136-224.;
STRAIN=Tuebingen
COMMENT On Jul 11, 2006 this sequence version replaced gi:82249195.
[FUNCTION] Sequence-specific transcription factor. Part of a
developmental regulatory system that provides cells with specific
positional identities on the anterior-posterior axis (By
similarity). {ECO:0000250|UniProtKB:Q90423}.
[SUBCELLULAR LOCATION] Nucleus
{ECO:0000255|PROSITE-ProRule:PRU00108}.
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
isoforms=2; Name=1; IsoId=Q98SI1-1; Sequence=Displayed; Name=2;
IsoId=Q98SI1-2; Sequence=VSP_012678.
[SIMILARITY] Belongs to the Antp homeobox family. Labial subfamily.
{ECO:0000305}.
FEATURES Location/Qualifiers
source 1..329
/organism="Danio rerio"
/db_xref="taxon:7955"
gene 1..329
/gene="hoxa1a"
/gene_synonym="hoxa1"
Protein 1..329
/product="Homeobox protein Hox-A1a"
/note="Hox-A1"
/UniProtKB_evidence="Evidence at transcript level"
Region 1..329
/region_name="Mature chain"
/note="Homeobox protein Hox-A1a. /id=PRO_0000200033."
Region 1..28
/region_name="Conflict"
/note="MSTFLDFSSISGGGDGGSGGSCSVRAFH -> MEVAGARAQSGRSQ (in
Ref. 2). /evidence=ECO:0000305."
Region 158..192
/region_name="Splicing variant"
/note="Missing (in isoform 2).
/evidence=ECO:0000303|PubMed:11493564. /id=VSP_012678."
Region 200..205
/region_name="Short sequence motif of biological interest"
/note="Antp-type hexapeptide."
Region 208..227
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Site 225..284
/site_type="DNA binding"
/note="Homeobox.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00108."
Region 229..282
/region_name="Homeodomain"
/note="pfam00046"
/db_xref="CDD:459649"
Region 277..329
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 279..308
/region_name="Compositionally biased region"
/note="Basic and acidic residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 296
/region_name="Conflict"
/note="Q -> E (in Ref. 1; CAC34566).
/evidence=ECO:0000305."
Region 309..329
/region_name="Compositionally biased region"
/note="Polar residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN
1 mstfldfssi sgggdggsgg scsvrafhgd hglstfqssc avrlnscsgd erfmsnissq
61 dvinsqpqqa gsyqspgtls itysahpsyg tqsfctgynh yalnqdvess vsfpqcgplv
121 ysgnisstvv qhrhhrhgys sgnvhlhgqf qygsatygns sdqanltfva gcsnplsplh
181 vphhdaccsp lsdgvptgqt fdwmkvkrnp pktgkageyg fggqpntvrt nfstkqltel
241 ekefhfnkyl trarrveiaa slqlnetqvk iwfqnrrmkq kkrekegllp kslseqkdgl
301 ektedaseks psapstpsps ptveayssn
//