LOCUS NP_476714 575 aa linear INV 26-DEC-2023
DEFINITION shaggy, isoform A [Drosophila melanogaster].
ACCESSION NP_476714
VERSION NP_476714.1
DBLINK BioProject: PRJNA164
BioSample: SAMN02803731
DBSOURCE REFSEQ: accession NM_057366.5
KEYWORDS RefSeq.
SOURCE Drosophila melanogaster (fruit fly)
ORGANISM Drosophila melanogaster
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE 1 (residues 1 to 575)
AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
Strelets,V., Russo,S.M. and Gelbart,W.M.
CONSRTM FlyBase Consortium
TITLE Gene Model Annotations for Drosophila melanogaster: Impact of
High-Throughput Data
JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015)
PUBMED 26109357
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 575)
AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
Russo,S.M. and Gelbart,W.M.
CONSRTM FlyBase Consortium
TITLE Gene Model Annotations for Drosophila melanogaster: The
Rule-Benders
JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015)
PUBMED 26109356
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 575)
AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
TITLE The Release 6 reference sequence of the Drosophila melanogaster
genome
JOURNAL Genome Res 25 (3), 445-458 (2015)
PUBMED 25589440
REFERENCE 4 (residues 1 to 575)
AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
TITLE Sequence finishing and mapping of Drosophila melanogaster
heterochromatin
JOURNAL Science 316 (5831), 1625-1628 (2007)
PUBMED 17569867
REFERENCE 5 (residues 1 to 575)
AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
TITLE The Release 5.1 annotation of Drosophila melanogaster
heterochromatin
JOURNAL Science 316 (5831), 1586-1591 (2007)
PUBMED 17569856
REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE 6 (residues 1 to 575)
AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
Ashburner,M. and Anxolabehere,D.
TITLE Combined evidence annotation of transposable elements in genome
sequences
JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005)
PUBMED 16110336
REFERENCE 7 (residues 1 to 575)
AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
Celniker,S.E., Rubin,G.M. and Karpen,G.H.
TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun
assembly
JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002)
PUBMED 12537574
REFERENCE 8 (residues 1 to 575)
AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
Rubin,G.M., Ashburner,M. and Celniker,S.E.
TITLE The transposable elements of the Drosophila melanogaster
euchromatin: a genomics perspective
JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002)
PUBMED 12537573
REFERENCE 9 (residues 1 to 575)
AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
Rubin,G.M. and Lewis,S.E.
TITLE Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review
JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002)
PUBMED 12537572
REFERENCE 10 (residues 1 to 575)
AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
Gibbs,R.A. and Rubin,G.M.
TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila
melanogaster euchromatic genome sequence
JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002)
PUBMED 12537568
REFERENCE 11 (residues 1 to 575)
AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
TITLE The genome sequence of Drosophila melanogaster
JOURNAL Science 287 (5461), 2185-2195 (2000)
PUBMED 10731132
REFERENCE 12 (residues 1 to 575)
AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
Smith,E., Yu,C. and Rubin,G.
CONSRTM Berkeley Drosophila Genome Project
TITLE Drosophila melanogaster release 4 sequence
JOURNAL Unpublished
REFERENCE 13 (residues 1 to 575)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 14 (residues 1 to 575)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 15 (residues 1 to 575)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 16 (residues 1 to 575)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 17 (residues 1 to 575)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 18 (residues 1 to 575)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 19 (residues 1 to 575)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 20 (residues 1 to 575)
AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
Park,S., Svirskas,R. and Karpen,G.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
REMARK Direct Submission
REFERENCE 21 (residues 1 to 575)
AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
Svirskas,R. and Rubin,G.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
64-121, Berkeley, CA 94720, USA
REMARK Direct Submission
REFERENCE 22 (residues 1 to 575)
AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
CONSRTM Drosophila Heterochromatin Genome Project
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE 23 (residues 1 to 575)
AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
TITLE Direct Submission
JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
Rockville, MD 20850, USA
COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The
reference sequence is identical to AAN09082.
##Genome-Annotation-Data-START##
Annotation Provider :: FlyBase
Annotation Status :: Full annotation
Annotation Version :: Release 6.54
URL :: http://flybase.org
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..575
/organism="Drosophila melanogaster"
/db_xref="taxon:7227"
/chromosome="X"
/genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
Protein 1..575
/product="shaggy, isoform A"
/EC_number="2.7.11.1"
/name="CG2621 gene product from transcript CG2621-RA"
/note="CG2621-PA; sgg-PA; zestewhite-3; glycogen synthase
kinase 3; zeste-white 3; Shaggy/Glycogen synthase kinase
3; GSK3betagr; zeste white 3; shaggy/zeste-white 3;
glycogen synthase Kinase-3; Zeste-white3;
Shaggy/Zeste-white-3/Glycogen synthase kinase 3beta;
zest-white 3; zeste white3; zeste white-3; GSK-3 kinase;
saggy; Zw3 kinase; glycogen synthase kinase 3Beta;
shaggy-zeste white 3; glycogen synthase kinase-3beta"
/calculated_mol_wt=58641
Region 50..341
/region_name="STKc_GSK3"
/note="The catalytic domain of the Serine/Threonine
Kinase, Glycogen Synthase Kinase 3; cd14137"
/db_xref="CDD:271039"
Site order(60..64,68,81,83,94,108,130..133,136,138..139,179,
181,183..184,186,198,201,212,214..217,219,257)
/site_type="active"
/db_xref="CDD:271039"
Site order(60..63,68,81,83,108,130..133,136,181,183..184,186,
198)
/site_type="other"
/note="ATP binding site [chemical binding]"
/db_xref="CDD:271039"
Site order(64..65,210..218,226..227,258..262,264..265,269,
289..292)
/site_type="other"
/note="dimer interface [polypeptide binding]"
/db_xref="CDD:271039"
Site order(94,138,179,181,201,212,214..217,219,257)
/site_type="other"
/note="polypeptide substrate binding site [polypeptide
binding]"
/db_xref="CDD:271039"
Site order(197..207,209..219)
/site_type="other"
/note="activation loop (A-loop)"
/db_xref="CDD:271039"
Site order(226,261..262,264..265,268..269,289..294)
/site_type="other"
/note="axin binding site [polypeptide binding]"
/db_xref="CDD:271039"
CDS 1..575
/gene="sgg"
/locus_tag="Dmel_CG2621"
/gene_synonym="anon-WO03040301.254; CG2621; Dm Zw3;
Dmel\CG2621; Dmsgg3; DMSGG3; DMZ3K25Z; EG:155E2.3;
EG:BACR7C10.8; GSK; Gsk-3; GSK-3; GSK-3B; Gsk-3beta;
GSK-3beta; gsk3; Gsk3; GSK3; Gsk3-beta; GSK3-beta; GSK3A;
Gsk3beta; GSK3beta; GSK3Beta; GSK3beta/SGG; GSK3betagr;
GSKbeta; l(1)3Ba; l(1)G0055; l(1)G0183; l(1)G0263;
l(1)G0335; l(1)zw3; Sgg; SGG; sgg-1; sgg-zw3; sgg/GSK3;
SGG/GSK3b; sgg/zw3; Sgg/Zw3/GSK3; sgg10; sgg39; sgG4;
sgg46; Shaggy; SHAGGY; zw-3; Zw-3; ZW-3; zw3; Zw3; ZW3;
zw3(sgg); Zw3-sh; Zw3/GSK3; zw3/GSK3beta; zw3/sgg;
zw3[sgg]; Zw3[sgg]; zw[3]"
/coded_by="NM_057366.5:647..2374"
/db_xref="FLYBASE:FBpp0070450"
/db_xref="GeneID:31248"
/db_xref="FLYBASE:FBgn0003371"
ORIGIN
1 msgrprtssf aegnkqspsl vlggvktcsr dgskittvva tpgqgtdrvq evsytdtkvi
61 gngsfgvvfq aklcdtgelv aikkvlqdrr fknrelqimr klehcnivkl lyffyssgek
121 rdevflnlvl eyipetvykv arqyaktkqt ipinfirlym yqlfrslayi hslgichrdi
181 kpqnllldpe tavlklcdfg sakqllhgep nvsyicsryy rapelifgai nyttkidvws
241 agcvlaelll gqpifpgdsg vdqlvevikv lgtptreqir emnpnytefk fpqikshpwq
301 kvfrirtpte ainlvsllle ytpsaritpl kacahpffde lrmegnhtlp ngrdmpplfn
361 ftehelsiqp slvpqllpkh lqnasgpggn rpsaggaasi aasgstsvss tgsgasvegs
421 aqpqsqgtaa aagsgsggat agtggasagg pgsgnnsssg gasgapsava agganaavag
481 gagggggaga ataaatatga igatnaggan vtgsqsnsal nssgsggsgn geaagsgsgs
541 gsgsgggngg dndagdsgai asgggaaete aaasg
//