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zinc finger and SCAN domain-containing protein 5A isoform c [Homo sapiens]

NCBI Reference Sequence: NP_001374784.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001374784             495 aa            linear   PRI 21-AUG-2024
DEFINITION  zinc finger and SCAN domain-containing protein 5A isoform c [Homo
            sapiens].
ACCESSION   NP_001374784
VERSION     NP_001374784.1
DBSOURCE    REFSEQ: accession NM_001387855.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 495)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 495)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (residues 1 to 495)
  AUTHORS   Sun,Y., Zhang,H., Kazemian,M., Troy,J.M., Seward,C., Lu,X. and
            Stubbs,L.
  TITLE     ZSCAN5B and primate-specific paralogs bind RNA polymerase III genes
            and extra-TFIIIC (ETC) sites to modulate mitotic progression
  JOURNAL   Oncotarget 7 (45), 72571-72592 (2016)
   PUBMED   27732952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006116.1 and AC011506.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4515071.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2148093,
                                           SAMEA2158188 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     Protein         1..495
                     /product="zinc finger and SCAN domain-containing protein
                     5A isoform c"
                     /note="zinc finger protein 495; zinc finger and SCAN
                     domain containing 5; zinc finger and SCAN
                     domain-containing protein 5A"
                     /calculated_mol_wt=55632
     Region          40..124
                     /region_name="SCAN"
                     /note="SCAN oligomerization domain; cd07936"
                     /db_xref="CDD:153421"
     Site            order(47..48,50..52,57..59,61..62,65..66,69..70,72..75,
                     79..80,83..84,87..89,91..92,94..97,116,119..120,122..124)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:153421"
     Region          152..183
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BUG6.1)"
     Region          <156..>354
                     /region_name="Treacle"
                     /note="Treacher Collins syndrome protein Treacle;
                     pfam03546"
                     /db_xref="CDD:460967"
     Region          357..377
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          370..392
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          385..405
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          397..422
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          413..433
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(418,420,422,424..425,428..429,432,446,448,452..453,
                     456..457,460,474,476,478,480..481,484..485,488)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          429..450
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          441..461
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          453..478
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..495
                     /gene="ZSCAN5A"
                     /gene_synonym="ZNF495; ZSCAN5"
                     /coded_by="NM_001387855.1:358..1845"
                     /note="isoform c is encoded by transcript variant 20"
                     /db_xref="CCDS:CCDS82403.1"
                     /db_xref="GeneID:79149"
                     /db_xref="HGNC:HGNC:23710"
                     /db_xref="MIM:620916"
ORIGIN      
        1 maanctssws lgescnrpgl elprsmasse tqlgnhdvdp eishvnfrmf scpkesdpiq
       61 alrkltelch lwlrpdlhtk eqildmlvme qfmismpqel qvlvmmngvq sckdledllr
      121 nnrrpkkwsv vtfhgkeyiv qdsdiemaea pssvrddlkd vssqrassvn qmrpgegqah
      181 relqilprvp alsrrqgedf llhksidvtg dpkslrpkqt lekdlkenre enpgltspep
      241 qlpkspnlvr akegkdppki asvenvdadt psacvverea sthsgnrgda lnlsspkrsk
      301 pdassisqee pqgeatpvgn respgqagmn sihspgpasp vshpdgqeak alppfacdvc
      361 ekrftcnskl vihkrshtge rlfqcnlcgk rfmqlislqf hqrthtgerp ytcdvcqkqf
      421 tqksylkchk rshtgekpfe ckdckkvfty rgslkehqri hsgekpykcs kcprafsrlk
      481 llrrhqkthp eatsq
//
1..495
/gene="ZSCAN5A"
/gene_synonym="ZNF495; ZSCAN5"
/coded_by="NM_001387855.1:358..1845"
/note="isoform c is encoded by transcript variant 20"
/db_xref="CCDS:CCDS82403.1"
/db_xref="GeneID:79149"
/db_xref="HGNC:HGNC:23710"
/db_xref="MIM:620916"
Feature NP_001374784 : 1 segment
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