LOCUS NP_001374784 495 aa linear PRI 21-AUG-2024
DEFINITION zinc finger and SCAN domain-containing protein 5A isoform c [Homo
sapiens].
ACCESSION NP_001374784
VERSION NP_001374784.1
DBSOURCE REFSEQ: accession NM_001387855.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 495)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (residues 1 to 495)
AUTHORS Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
Schubeler,D., Vinson,C. and Taipale,J.
TITLE Impact of cytosine methylation on DNA binding specificities of
human transcription factors
JOURNAL Science 356 (6337) (2017)
PUBMED 28473536
REFERENCE 3 (residues 1 to 495)
AUTHORS Sun,Y., Zhang,H., Kazemian,M., Troy,J.M., Seward,C., Lu,X. and
Stubbs,L.
TITLE ZSCAN5B and primate-specific paralogs bind RNA polymerase III genes
and extra-TFIIIC (ETC) sites to modulate mitotic progression
JOURNAL Oncotarget 7 (45), 72571-72592 (2016)
PUBMED 27732952
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC006116.1 and AC011506.3.
##Evidence-Data-START##
Transcript exon combination :: SRR14038194.4515071.1 [ECO:0000332]
RNAseq introns :: partial sample support SAMEA2148093,
SAMEA2158188 [ECO:0000350]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..495
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.43"
Protein 1..495
/product="zinc finger and SCAN domain-containing protein
5A isoform c"
/note="zinc finger protein 495; zinc finger and SCAN
domain containing 5; zinc finger and SCAN
domain-containing protein 5A"
/calculated_mol_wt=55632
Region 40..124
/region_name="SCAN"
/note="SCAN oligomerization domain; cd07936"
/db_xref="CDD:153421"
Site order(47..48,50..52,57..59,61..62,65..66,69..70,72..75,
79..80,83..84,87..89,91..92,94..97,116,119..120,122..124)
/site_type="other"
/note="dimerization interface [polypeptide binding]"
/db_xref="CDD:153421"
Region 152..183
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9BUG6.1)"
Region <156..>354
/region_name="Treacle"
/note="Treacher Collins syndrome protein Treacle;
pfam03546"
/db_xref="CDD:460967"
Region 357..377
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 370..392
/region_name="zf-H2C2_2"
/note="Zinc-finger double domain; pfam13465"
/db_xref="CDD:463886"
Region 385..405
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 397..422
/region_name="zf-H2C2_2"
/note="Zinc-finger double domain; pfam13465"
/db_xref="CDD:463886"
Region 413..433
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(418,420,422,424..425,428..429,432,446,448,452..453,
456..457,460,474,476,478,480..481,484..485,488)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 429..450
/region_name="zf-H2C2_2"
/note="Zinc-finger double domain; pfam13465"
/db_xref="CDD:463886"
Region 441..461
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 453..478
/region_name="zf-H2C2_2"
/note="Zinc-finger double domain; pfam13465"
/db_xref="CDD:463886"
Region 469..489
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
CDS 1..495
/gene="ZSCAN5A"
/gene_synonym="ZNF495; ZSCAN5"
/coded_by="NM_001387855.1:358..1845"
/note="isoform c is encoded by transcript variant 20"
/db_xref="CCDS:CCDS82403.1"
/db_xref="GeneID:79149"
/db_xref="HGNC:HGNC:23710"
/db_xref="MIM:620916"
ORIGIN
1 maanctssws lgescnrpgl elprsmasse tqlgnhdvdp eishvnfrmf scpkesdpiq
61 alrkltelch lwlrpdlhtk eqildmlvme qfmismpqel qvlvmmngvq sckdledllr
121 nnrrpkkwsv vtfhgkeyiv qdsdiemaea pssvrddlkd vssqrassvn qmrpgegqah
181 relqilprvp alsrrqgedf llhksidvtg dpkslrpkqt lekdlkenre enpgltspep
241 qlpkspnlvr akegkdppki asvenvdadt psacvverea sthsgnrgda lnlsspkrsk
301 pdassisqee pqgeatpvgn respgqagmn sihspgpasp vshpdgqeak alppfacdvc
361 ekrftcnskl vihkrshtge rlfqcnlcgk rfmqlislqf hqrthtgerp ytcdvcqkqf
421 tqksylkchk rshtgekpfe ckdckkvfty rgslkehqri hsgekpykcs kcprafsrlk
481 llrrhqkthp eatsq
//