LOCUS NM_029457 4499 bp mRNA linear ROD 21-MAY-2024
DEFINITION Mus musculus SUMO/sentrin specific peptidase 2 (Senp2), transcript
variant 1, mRNA.
ACCESSION NM_029457
VERSION NM_029457.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 4499)
AUTHORS Luo,Y., Zhou,S., Xu,T., Wu,W., Shang,P., Wang,S., Pan,D. and Li,D.
TITLE SENP2-mediated SERCA2a deSUMOylation increases calcium overload in
cardiomyocytes to aggravate myocardial ischemia/reperfusion injury
JOURNAL Chin Med J (Engl) 136 (20), 2496-2507 (2023)
PUBMED 37462038
REMARK GeneRIF: SENP2-mediated SERCA2a deSUMOylation increases calcium
overload in cardiomyocytes to aggravate myocardial
ischemia/reperfusion injury.
REFERENCE 2 (bases 1 to 4499)
AUTHORS Nguyen,M.T.H., Imanishi,M., Li,S., Chau,K., Banerjee,P.,
Velatooru,L.R., Ko,K.A., Samanthapudi,V.S.K., Gi,Y.J., Lee,L.L.,
Abe,R.J., McBeath,E., Deswal,A., Lin,S.H., Palaskas,N.L.,
Dantzer,R., Fujiwara,K., Borchrdt,M.K., Turcios,E.B.,
Olmsted-Davis,E.A., Kotla,S., Cooke,J.P., Wang,G., Abe,J.I. and
Le,N.T.
TITLE Endothelial activation and fibrotic changes are impeded by laminar
flow-induced CHK1-SENP2 activity through mechanisms distinct from
endothelial-to-mesenchymal cell transition
JOURNAL Front Cardiovasc Med 10, 1187490 (2023)
PUBMED 37711550
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 4499)
AUTHORS Yang,T.T., Chiang,M.F., Chang,C.C., Yang,S.Y., Huang,S.W.,
Liao,N.S., Shih,H.M., Hsu,W. and Lin,K.I.
TITLE SENP2 restrains the generation of pathogenic Th17 cells in mouse
models of colitis
JOURNAL Commun Biol 6 (1), 629 (2023)
PUBMED 37301920
REMARK GeneRIF: SENP2 restrains the generation of pathogenic Th17 cells in
mouse models of colitis.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 4499)
AUTHORS Kim,P.C., Lee,J.S., Chung,S.S. and Park,K.S.
TITLE Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid
Metabolism in White Adipocytes
JOURNAL Diabetes Metab J 47 (3), 382-393 (2023)
PUBMED 36872063
REMARK GeneRIF: Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty
Acid Metabolism in White Adipocytes.
REFERENCE 5 (bases 1 to 4499)
AUTHORS Dufour,D., Dumontet,T., Sahut-Barnola,I., Carusi,A., Onzon,M.,
Pussard,E., Wilmouth,J.J., Olabe,J., Lucas,C., Levasseur,A.,
Damon-Soubeyrand,C., Pointud,J.C., Roucher-Boulez,F., Tauveron,I.,
Bossis,G., Yeh,E.T., Breault,D.T., Val,P., Lefrancois-Martinez,A.M.
and Martinez,A.
TITLE Loss of SUMO-specific protease 2 causes isolated glucocorticoid
deficiency by blocking adrenal cortex zonal transdifferentiation in
mice
JOURNAL Nat Commun 13 (1), 7858 (2022)
PUBMED 36543805
REMARK GeneRIF: Loss of SUMO-specific protease 2 causes isolated
glucocorticoid deficiency by blocking adrenal cortex zonal
transdifferentiation in mice.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4499)
AUTHORS Chiu,S.Y., Asai,N., Costantini,F. and Hsu,W.
TITLE SUMO-specific protease 2 is essential for modulating p53-Mdm2 in
development of trophoblast stem cell niches and lineages
JOURNAL PLoS Biol 6 (12), e310 (2008)
PUBMED 19090619
REMARK GeneRIF: data reveal a key genetic pathway, SENP2-Mdm2-p53,
underlying trophoblast lineage development, suggesting its pivotal
role in cell cycle progression of mitosis and endoreduplication.
REFERENCE 7 (bases 1 to 4499)
AUTHORS Cheng,J., Kang,X., Zhang,S. and Yeh,E.T.
TITLE SUMO-specific protease 1 is essential for stabilization of
HIF1alpha during hypoxia
JOURNAL Cell 131 (3), 584-595 (2007)
PUBMED 17981124
REFERENCE 8 (bases 1 to 4499)
AUTHORS Gomez-del Arco,P., Koipally,J. and Georgopoulos,K.
TITLE Ikaros SUMOylation: switching out of repression
JOURNAL Mol Cell Biol 25 (7), 2688-2697 (2005)
PUBMED 15767674
REFERENCE 9 (bases 1 to 4499)
AUTHORS Best,J.L., Ganiatsas,S., Agarwal,S., Changou,A., Salomoni,P.,
Shirihai,O., Meluh,P.B., Pandolfi,P.P. and Zon,L.I.
TITLE SUMO-1 protease-1 regulates gene transcription through PML
JOURNAL Mol Cell 10 (4), 843-855 (2002)
PUBMED 12419228
REMARK GeneRIF: SUMO-1 protease-1 regulates gene transcription through
PML.
REFERENCE 10 (bases 1 to 4499)
AUTHORS Nishida,T., Kaneko,F., Kitagawa,M. and Yasuda,H.
TITLE Characterization of a novel mammalian SUMO-1/Smt3-specific
isopeptidase, a homologue of rat axam, which is an axin-binding
protein promoting beta-catenin degradation
JOURNAL J Biol Chem 276 (42), 39060-39066 (2001)
PUBMED 11489887
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CJ169147.1, AK031030.1, CT030725.15 and CT009567.9.
On Apr 15, 2009 this sequence version replaced NM_029457.2.
Transcript Variant: This variant (1) encodes the functional
protein.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC031652.1, AK031030.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849375, SAMN00849380
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-18 CJ169147.1 1-18
19-2638 AK031030.1 4-2623
2639-3489 CT030725.15 114363-115213
3490-4499 CT009567.9 2001-3010
FEATURES Location/Qualifiers
source 1..4499
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="16"
/map="16 12.98 cM"
gene 1..4499
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="SUMO/sentrin specific peptidase 2"
/db_xref="GeneID:75826"
/db_xref="MGI:MGI:1923076"
exon 1..259
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
misc_feature 12..14
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="upstream in-frame stop codon"
CDS 159..1925
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/EC_number="3.4.22.68"
/note="isoform 1 is encoded by transcript variant 1;
SUMO/sentrin specific protease 2; SUMO-1/Smt3-specific
isopeptidase 2; sentrin-specific protease 2; SUMO-1
protease-1; axam2; sentrin/SUMO-specific protease SENP2"
/codon_start=1
/product="sentrin-specific protease 2 isoform 1"
/protein_id="NP_083733.1"
/db_xref="CCDS:CCDS28065.1"
/db_xref="GeneID:75826"
/db_xref="MGI:MGI:1923076"
/translation="MYRWLAKVLGTILRLCERPAPGARALLKRRRSSSTLFSTAVDTD
EIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVSSACNGTRNVAPSGEVFSN
SSSCELMSSGSCSSMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLKSEGYN
RRPSGRRHSKSNPESSLTWKPQEQGVTEMISEEGGKGVRRPHCTVEEGVQKDEREKYR
KLLERLKEGAHGSTFPPTVSHHSSQRIQMDTLKTKGWVEEQNHGVRTTHFVPKQYRVV
ETRGPLCSMRSEKRYSKGKADTEKVVGLRFEKEGTRGHQMEPDLSEEVSARLRLGSGS
NGLLRRKISVLEIKEKNFPSKEKDRRTEDLFEFTEDMEKEISNALGHGPPDEILSSAF
KLRITRGDIQTLKNYHWLNDEVINFYMNLLVERSKKQGYPALHAFSTFFYPKLKSGGY
QAVKRWTKGVNLFEQELVLVPIHRKVHWSLVVMDLRKKCLKYLDSMGQKGHRICEILL
QYLQDESKTKRNTDLNLLEWTHYSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITF
TQHQMPLFRKKMVWEILHQQLL"
misc_feature 240..251
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="propagated from UniProtKB/Swiss-Prot (Q91ZX6.2);
Region: Nuclear localization signal.
/evidence=ECO:0000255"
misc_feature 252..254
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9HC62; propagated from
UniProtKB/Swiss-Prot (Q91ZX6.2); phosphorylation site"
misc_feature 297..314
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="propagated from UniProtKB/Swiss-Prot (Q91ZX6.2);
Region: Nuclear localization signal.
/evidence=ECO:0000255"
misc_feature 627..710
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="propagated from UniProtKB/Swiss-Prot (Q91ZX6.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1104..1151
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="propagated from UniProtKB/Swiss-Prot (Q91ZX6.2);
Region: Nuclear export signal.
/evidence=ECO:0000250|UniProtKB:Q9HC62"
misc_feature 1152..1154
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9HC62; propagated from
UniProtKB/Swiss-Prot (Q91ZX6.2); phosphorylation site"
misc_feature 1185..1187
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9HC62; propagated from
UniProtKB/Swiss-Prot (Q91ZX6.2); phosphorylation site"
misc_feature 1338..1832
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="propagated from UniProtKB/Swiss-Prot (Q91ZX6.2);
Region: Protease. /evidence=ECO:0000250|UniProtKB:Q9HC62"
exon 260..318
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 319..452
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 453..519
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 520..610
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 611..779
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 780..880
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 881..975
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 976..1027
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 1028..1088
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 1089..1265
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 1266..1397
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 1398..1601
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 1602..1681
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 1682..1766
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 1767..1862
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
exon 1863..4499
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/inference="alignment:Splign:2.1.0"
regulatory 3085..3090
/regulatory_class="polyA_signal_sequence"
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="hexamer: AATAAA"
polyA_site 3106
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="major polyA site"
regulatory 4453..4458
/regulatory_class="polyA_signal_sequence"
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="hexamer: AGTAAA"
regulatory 4468..4473
/regulatory_class="polyA_signal_sequence"
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
/note="hexamer: AATACA"
polyA_site 4473
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
polyA_site 4499
/gene="Senp2"
/gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
Smt3ip2; SuPr-1"
ORIGIN
1 aagtccgcgc ctgatcctgg ctacggctga agcggcgaag gcggcagcgg cagcggcagc
61 ggcagcggcg acggcggcgg cggcggcggc ggcggcggcg acagctctgg ggttcgcgtc
121 tcggggtgtg tcggccgccg ctgctgctca ggcctggaat gtacagatgg ctggctaagg
181 ttctcggcac cattcttcgc ttgtgtgagc ggcccgcgcc cggggcccgc gccctactca
241 agaggcggcg ctccagcagc actctgtttt ctactgcagt ggacactgat gagatcccag
301 ccaaaaggcc aagattagat tgctttattc accaagtgaa gaacagtctc tacaatgctg
361 ccagtttatt tggattcccg ttccagctga ccacaaaacc catggtgtct tctgcttgta
421 atggaacacg gaatgtggcc ccttctggag aggtcttttc gaactcttca tcttgtgagc
481 tgatgagttc tggatcctgc agcagcatgc tgaaactggg taataaatct cctaatggaa
541 taagcgacta tccaaagatc agagtgacag tgacccgcga tcagccacgg agagtcctgc
601 cctcctttgg ttttacgctg aaatcggaag gctataatag aaggccaagt ggtcgtcgcc
661 atagcaaaag caatccagag agttccttaa catggaagcc tcaggagcaa ggtgtgacag
721 agatgatttc tgaagagggt ggcaagggtg tgaggcgtcc ccactgcacc gtggaggagg
781 gtgtccaaaa ggatgaaaga gaaaagtatc gaaagttatt ggagcgactt aaagaaggtg
841 ctcatggaag cacgttccct cccacggttt cacaccacag ttctcagaga attcagatgg
901 acacattaaa gaccaaaggc tgggtggagg agcagaatca tggcgtcaga acaacccatt
961 ttgttccaaa acagtataga gttgttgaaa caagaggacc tctctgttca atgagaagtg
1021 aaaagaggta ttcaaaaggg aaagctgata cagagaaggt ggtgggactc cgatttgaaa
1081 aggaaggtac aagaggacac caaatggagc ctgatctgtc agaagaagtg tctgcccgac
1141 ttcgtctagg aagtggaagc aatggcttac tcagaaggaa aatatcagtg cttgagataa
1201 aggaaaagaa cttcccgagc aaagagaagg acagaagaac ggaagacctc tttgaattta
1261 cagaggacat ggaaaaggaa atcagtaatg ccctgggcca cggcccacca gatgagattt
1321 tgagcagcgc tttcaagttg cgaatcaccc gcggagacat ccagacctta aagaactatc
1381 attggctcaa cgatgaggtc attaattttt atatgaatct tttagtggaa aggagtaaaa
1441 agcaaggtta tccagcactt catgcattca gtacattctt ctatcctaag ctaaagtctg
1501 gaggttacca agcagtgaaa agatggacca aaggggtaaa tctcttcgaa caagaacttg
1561 ttctggtacc tattcatcgg aaggtacatt ggagcctggt ggtgatggac ctaagaaaaa
1621 agtgtcttaa atatctggat tctatgggac aaaaaggcca caggatctgt gagattcttc
1681 ttcagtattt acaggatgaa agcaagacca aaagaaatac agatctcaac ctcttagagt
1741 ggacccacta cagcatgaag ccacatgaga ttcctcagca gttgaatggg agtgactgtg
1801 gaatgtttac ttgtaaatat gcagattata tttctaggga caaacctatc acattcactc
1861 agcaccagat gcctctcttc cggaagaaga tggtgtggga gatccttcac cagcagttgc
1921 tgtgacaatg ccccgcctgg tcttctagct gctggtggtt ctttgatgga tgtttccata
1981 tacctcatgc attgtgggtt aaaaagtccc cgatcatttc tcttctctca caggtactga
2041 gctctcaaga gtgcatgaag gcctctccac aatggccctg actagaggtg tggaggggct
2101 gcttgaaacc ctgtttctaa ggctgtgcct gctcagagcc ctggactatt caccccatac
2161 aagaacaaat gctaattaat gtgttttgtt ttaaagcgtt atttccatat gaatgtggga
2221 aatgcaggat ctgttatatg aattgttctg tgtgttcaca cgaattcact ctctcattgg
2281 gcagtgccct tttcccactg ctcttttata attagctata aataatttgg actatttatt
2341 tctgaaaaga atgttaatca aactgccact tcctgctgca gagagatatc agcaggggga
2401 ggaaggaggt gttcgctagc ttctctaatg ctggagtgcg aactgccgac atacagttaa
2461 ggttctctct tttaaggctt gaaaatgcca gaagaaatga cgatgctctg ttgtaggatc
2521 tggctgcctt ttagagagtc tgatgctatg acacgggcac agttcgtgga aatgtggcca
2581 aggaactcga tctgtgcatc ctcagaacgg ggcgtgcgca tcttagagac tttcttttct
2641 agaaccgaag tagcttggct tcctcttgaa actggattca aagtaactgt gagcatccat
2701 gttaagtcgt aggtctggtg agtgagtgtg tgagcctcac cagggaaggg ctggcctgag
2761 ctgtctgctc tgaagatgct cctcaatgga agcctatttt tcctcagagt tttttttttt
2821 tttaatatat atatatataa agctgaaatt aagttcttgg ctcatcagca tgccccactc
2881 cagccccact gagcctttgg agagagatta gtacttggct ctgaggttgc caggtttaca
2941 ggcatctatt ttgcatatga aagtttgtat ttaacttttt tgttcattaa aaatcttaca
3001 ggtgtggtta tgcattgtca atttcagaaa gttggtcaga gcacattttg caagatctag
3061 tgcctagtgt tgcttttatg acgtaataaa agactggcag aacctagagt atattctgat
3121 aatttttcct cttttctctg cctcaacctt ccaaagttgt tctggtacaa aaagagagag
3181 aaagagagag ataaaattag aaaagctgca cacatgttag atacaaacgt acacgtctgc
3241 tcttgggacg cctgggcagc tgatcagagg ttgtagctgt tgaaacctgt ttgctctgag
3301 acttgaaatg accttcgtta tggaagctgg gcctgtgatg gggactgaaa tggctgagcc
3361 aacccgagac caggtggcct aaacctgaaa gcgagcatgt ggtctaacaa ttcaggggta
3421 aacggtgttg taacctcctc aaggcagact acacagggac cccttccttt atttagccta
3481 gacccccccc ccccccaagc actgtgccag tgatgccggg atcaggcagc tggtctaacc
3541 aaaagagccc agaagttgat cctgtctaca ctactaaaac ctgggtgcta gaattctacc
3601 tgagaattta tgatcccggc ctatcaaaca aaatagctac ctgaccagag tttgatcccc
3661 agtgcccaca ctggagggcg aaaactgact ccccaaaatt gtcctcagac ctccatactt
3721 gcacaaacca acagatggac caaattagta ataagtaaaa aaaaattaaa ggaattttaa
3781 gggccttgga taggtttgtt tctgttggct cagtcctgct tggatggcga ctttctctcc
3841 ccaggtgagt gatgctatag ctaatgtggc atttgaaggt gtcctcaagc tcgccacccg
3901 ggtgtgctta gaacaggaac ctggagagac agatggttgg gtggtgaggc caggattgac
3961 ttttagtctc agccaggtgt gtctgtaaca agctggatcc ctgctcacat ctgtaatccc
4021 agttcccagt ggggagaggc agggtcggta gatccttcct gggaggagca ggaagagtga
4081 tggagaacaa cttccctctc ccatgtctgc tcataagcgc atccaccaca ttcctgtgca
4141 cacacagtaa gttcttatag aagatggaaa atgcaaaagt acagaatgtt aagctatggt
4201 ggcactgctt tacctgagtg tctgaatcca agctaaggta ccagaagccc cagctctctg
4261 tcacctgtgt gcgcacgggt aacagaactg ttacattgag cttatgagaa gaatacagat
4321 aagtgagaaa cagcacttgg tgtaactagt gagtcggcaa aattaaagcc ggtaatgttt
4381 ttgtgaaatt tcaattttgg aacctgaaag aaatgttgca ttgttctgtt tagcccatag
4441 tctctaaaaa tgagtaaaag tttaagaaat acacactgct ggtgacatct ctttctgca
//