LOCUS NM_008024 2960 bp mRNA linear ROD 16-NOV-2021
DEFINITION Mus musculus forkhead box L1 (Foxl1), mRNA.
ACCESSION NM_008024
VERSION NM_008024.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 2960)
AUTHORS Yogosawa S, Ohkido M, Horii T, Okazaki Y, Nakayama J, Yoshida S,
Toyokuni S, Hatada I, Morimoto M and Yoshida K.
TITLE Mice lacking DYRK2 exhibit congenital malformations with lung
hypoplasia and altered Foxf1 expression gradient
JOURNAL Commun Biol 4 (1), 1204 (2021)
PUBMED 34671097
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 2960)
AUTHORS Kondo A and Kaestner KH.
TITLE FoxL1(+) mesenchymal cells are a critical source of Wnt5a for
midgut elongation during mouse embryonic intestinal development
JOURNAL Cells Dev 165, 203662 (2021)
PUBMED 33993983
REFERENCE 3 (bases 1 to 2960)
AUTHORS Weiss AC, Bohnenpoll T, Kurz J, Blank P, Airik R, Ludtke TH, Kleppa
MJ, Deuper L, Kaiser M, Mamo TM, Costa R, von Hahn T, Trowe MO and
Kispert A.
TITLE Delayed onset of smooth muscle cell differentiation leads to
hydroureter formation in mice with conditional loss of the zinc
finger transcription factor gene Gata2 in the ureteric mesenchyme
JOURNAL J Pathol 248 (4), 452-463 (2019)
PUBMED 30916783
REFERENCE 4 (bases 1 to 2960)
AUTHORS Honda K, Kim SH, Kelly MC, Burns JC, Constance L, Li X, Zhou F, Hoa
M, Kelley MW, Wangemann P, Morell RJ and Griffith AJ.
TITLE Molecular architecture underlying fluid absorption by the
developing inner ear
JOURNAL Elife 6, e26851 (2017)
PUBMED 28994389
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 2960)
AUTHORS Chan AL, La HM, Legrand JMD, Makela JA, Eichenlaub M, De Seram M,
Ramialison M and Hobbs RM.
TITLE Germline Stem Cell Activity Is Sustained by SALL4-Dependent
Silencing of Distinct Tumor Suppressor Genes
JOURNAL Stem Cell Reports 9 (3), 956-971 (2017)
PUBMED 28867346
REMARK GeneRIF: SALL4 associated with the NuRD co-repressor and repressed
expression of the tumor suppressor genes Foxl1 and Dusp4.
REFERENCE 6 (bases 1 to 2960)
AUTHORS Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M,
Kageyama R, Guillemot F, Serup P and Madsen OD.
TITLE Control of endodermal endocrine development by Hes-1
JOURNAL Nat Genet 24 (1), 36-44 (2000)
PUBMED 10615124
REFERENCE 7 (bases 1 to 2960)
AUTHORS Kaestner KH, Silberg DG, Traber PG and Schutz G.
TITLE The mesenchymal winged helix transcription factor Fkh6 is required
for the control of gastrointestinal proliferation and
differentiation
JOURNAL Genes Dev 11 (12), 1583-1595 (1997)
PUBMED 9203584
REFERENCE 8 (bases 1 to 2960)
AUTHORS Kaestner KH, Bleckmann SC, Monaghan AP, Schlondorff J, Mincheva A,
Lichter P and Schutz G.
TITLE Clustered arrangement of winged helix genes fkh-6 and MFH-1:
possible implications for mesoderm development
JOURNAL Development 122 (6), 1751-1758 (1996)
PUBMED 8674414
REFERENCE 9 (bases 1 to 2960)
AUTHORS Pierrou S, Hellqvist M, Samuelsson L, Enerback S and Carlsson P.
TITLE Cloning and characterization of seven human forkhead proteins:
binding site specificity and DNA bending
JOURNAL EMBO J 13 (20), 5002-5012 (1994)
PUBMED 7957066
REFERENCE 10 (bases 1 to 2960)
AUTHORS Kaestner KH, Lee KH, Schlondorff J, Hiemisch H, Monaghan AP and
Schutz G.
TITLE Six members of the mouse forkhead gene family are developmentally
regulated
JOURNAL Proc Natl Acad Sci U S A 90 (16), 7628-7631 (1993)
PUBMED 7689224
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC127554.4.
[WARNING] On Feb 1, 2022 this sequence was replaced by NM_008024.3.
On Jan 5, 2007 this sequence version replaced NM_008024.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2960 AC127554.4 51268-54227
FEATURES Location/Qualifiers
source 1..2960
/organism="Mus musculus"
/mol_type="mRNA"
/db_xref="taxon:10090"
/chromosome="8"
/map="8 70.34 cM"
gene 1..2960
/gene="Foxl1"
/gene_synonym="fkh-6; Fkh6; FREAC7"
/note="forkhead box L1"
/db_xref="GeneID:14241"
/db_xref="MGI:MGI:1347469"
exon 1..2960
/gene="Foxl1"
/gene_synonym="fkh-6; Fkh6; FREAC7"
/inference="alignment:Splign:2.1.0"
misc_feature 140..142
/gene="Foxl1"
/gene_synonym="fkh-6; Fkh6; FREAC7"
/note="upstream in-frame stop codon"
misc_feature 156..1590
/gene="Foxl1"
/gene_synonym="fkh-6; Fkh6; FREAC7"
/note="CpG_island (%GC=66.5, o/e=0.72, #CpGs=121)"
CDS 278..1288
/gene="Foxl1"
/gene_synonym="fkh-6; Fkh6; FREAC7"
/note="transcription factor FKH-6; forkhead-related
protein FKHL11; forkhead homolog 6"
/codon_start=1
/product="forkhead box protein L1"
/protein_id="NP_032050.2"
/db_xref="CCDS:CCDS59744.1"
/db_xref="GeneID:14241"
/db_xref="MGI:MGI:1347469"
/translation="MSHLFSPPLAALAASPLLYVYSPERPGLPLAFAPAAALAGPGRV
EPPQKPPYSYIALIAMAIQDAPEQRVTLNGIYQFIMDRFPFYHDNRQGWQNSIRHNLS
LNECFVKVPREKGRPGKGSYWTLDPRCLDMFENGNYRRRKRKPKPAAGSPEAKRTRVE
PPESEVGCDVGSPDLATALPTRAPDRSQSPAVGTARPALLPWPGPEPRDPDADLTVQG
AGAVASGQLQRPAHHLGSPLCPAPSGSPKGSKSKSFSIDSILAVRPTPASGAEAPGIP
KPVPGALGSSLLAASSGLAPPFNASLVFDAHVQGGFSQLGIPFLSYFPLQVPEATVLR
FH"
misc_feature 695..919
/gene="Foxl1"
/gene_synonym="fkh-6; Fkh6; FREAC7"
/note="propagated from UniProtKB/Swiss-Prot (Q64731.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 956..1033
/gene="Foxl1"
/gene_synonym="fkh-6; Fkh6; FREAC7"
/note="propagated from UniProtKB/Swiss-Prot (Q64731.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN
1 agattttcag caatgaaatt ttaattaatg tgggtgggct gagaacacaa ggactgttta
61 tcatagacaa tttattttcc agcgctaagt caacacataa tagcaaactt acaacaatta
121 tttaacattt ttaaagccat gaagaaggga caaagcgcgc agcggctggg gagagcggct
181 gatcgcaggg cagtcgcaca gagggctccc caggagggcc ctggtgcggg gcaaagtcct
241 taggactccc cggtggagcg gagaggctgc tgtcgccatg agccacctct tcagtccccc
301 gctggccgct ctggcagcct cgccgctgtt gtacgtgtac agccccgaga ggcctgggct
361 gcccctggcc ttcgcccctg cggctgcact ggccggcccg ggccgcgtcg agcccccgca
421 gaagccgccc tacagctaca tcgctcttat agccatggcg atccaggatg ctcccgagca
481 gagggtcaca ctgaacggca tctaccagtt catcatggat cgcttcccgt tctaccacga
541 caaccgccaa ggctggcaga acagcatccg ccacaacctg tcgctcaacg agtgcttcgt
601 gaaggtgcca cgtgagaagg ggcggccggg caagggcagc tactggaccc tggacccccg
661 ctgcttggac atgtttgaga acggcaatta tcggcgcagg aagaggaagc ccaagcccgc
721 cgcgggttcc ccggaggcca agcgcacccg ggtcgagccg ccggagtccg aggtgggctg
781 cgatgtaggg tccccggacc tggccactgc actcccgacg cgcgcgccgg atcgctccca
841 atccccggca gtaggcaccg cgcggcccgc gctccttccc tggcccggcc ctgagccccg
901 ggaccccgac gcggacctca cagtccaggg cgcaggggca gtggcaagcg gccagctcca
961 gcgtccggca caccacctgg ggtcccctct gtgccccgcc cccagcggct ccccaaaagg
1021 ttccaagtca aagagtttca gcatcgacag catcttggcc gtgagaccga cgccagcctc
1081 aggggccgaa gcaccgggga tccctaagcc cgtgcctggc gcgctgggct cctctctgct
1141 ggctgcctcc tccggcctag cgcctccctt caacgcttcg ctggtcttcg acgcgcacgt
1201 ccagggcggc ttttcccagc tggggattcc cttcctttct tattttcctc tgcaggttcc
1261 cgaggccaca gtgcttcgtt tccactaagg cggattagcg gctgcttccc tgcctcgcga
1321 tccccccacc tccagtgagc caatgcctgt gggcgaagga gtcgccccgg tctctgccct
1381 ggcagagact gagggtttgg agcagcgtac ccgtgccggc caaagtcgtg cactgagggg
1441 cctcgtccat ctgctttctc cgaagatgac ttaaccagcc accggaagct ttgcagattt
1501 aaaagactgg tccagtagag gacatggtcg ccgcacactc agccctcacg gttcgtctcc
1561 agcagaagcc cctcgtaggc tttggcggcg ttgtacagtg accaccacaa gtccccactc
1621 ggacctgagt ctcctgctga ccctgagggc aggacttaga gatatagcga acagctctat
1681 gtggaggttc aactggatca tggaaggctc agcgggctcc gtgtggcata ggccttggct
1741 ttgatctcat tggatgtggg gagcttgcag ccaggatgct ggggatgatc cgtggtccgc
1801 aggctctggg aaagatgtag gcctggttaa cgtttacaac taaggttgaa caaaagcagg
1861 ctcaccggaa atgctcaata tgaatagata aaccttcttc cagacaggga aaggctcatt
1921 tattcttggc ttataaacca ggctcccctt tgctatagct agtagcttct tttaaggagc
1981 cccgtgtgtt tggcacgtac tttggcttta cagtggcaca cctgccgcat tccacagcat
2041 agtcctctgt tcacttctgc ttttcttttc tttttttttt tttgtgtggg ggggaggggt
2101 tcgagacagg gtttctctgt atagccctgg ctgtcctgga actcactttg tagaccaggc
2161 tggcctgcct ctgcctcccg agagctggga ttaaaggcgt actccaccat gcctggcctg
2221 cttttctttt taaggcacca aaaaatttca ggggacacag aagggtgtgt gatcggaggg
2281 attattatga ctcaagggcg ggtttttttt ttaacttctg tagcttttta agatctaagt
2341 ccccccccca tctctctccc cccccccact cacactttcc agaaacacac acacagtgaa
2401 ggactacatg taatcagaga ggctggggga gcatactact cctgagtgtg ggagatagat
2461 agcttccagg agtgacaggg actctcttca gacaaagcct gtggtacctc aagtctgtgt
2521 tccctttata tccctccagg gagatctaga tattgacatt acataaaccc ataagaggtg
2581 accagagagc ggggttgagg gggagggggt ggggagatca acaaagtgct gactaaggca
2641 actaagttgg ttaccgtgca gtgcagtcct gcttccaaat ttgggggaaa ctctcaggcc
2701 tttggggtgc ccatgtttaa gcttgctggt gggctctgca actcagcttt cagaggaagg
2761 aaagtgctgg tccttgatgt aaaaaaaagg accaaaaatt aagaattcta gggcataggt
2821 ccacagtgat gtctcacaac aactaaggta tgccgtgcat cacacctgta atctcagtcc
2881 ttgcaaggct gaggcagggg gattgctgtg agtttaagga tagcttgtgg cacagagtta
2941 gacatgtctc aaactaaggg
//