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PDB: 3HXC_A
Identical Proteins FASTA Graphics
LOCUS 3HXC_A 331 aa linear ROD 21-FEB-2024 DEFINITION Chain A, Geranylgeranyl transferase type-2 subunit alpha. ACCESSION 3HXC_A VERSION 3HXC_A DBSOURCE pdb: molecule 3HXC, chain A, release Feb 21, 2024; deposition: Jun 20, 2009; class: TRANSFERASE; source: Mmdb_id: 76591, Pdb_id 1: 3HXC; Exp. method: X-ray Diffraction. KEYWORDS . SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (residues 1 to 331) AUTHORS Tan,K.T., Guiu-Rozas,E., Bon,R.S., Guo,Z., Delon,C., Wetzel,S., Arndt,S., Alexandrov,K., Waldmann,H., Goody,R.S., Wu,Y.W. and Blankenfeldt,W. TITLE Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors JOURNAL J Med Chem 52 (24), 8025-8037 (2009) PUBMED 19894725 REFERENCE 2 (residues 1 to 331) AUTHORS Guo,Z., Alexandrov,K., Waldmann,H., Goody,R.S. and Blankenfeldt,W. TITLE Direct Submission JOURNAL Submitted (20-JUN-2009) COMMENT Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 8). FEATURES Location/Qualifiers source 1..331 /organism="Rattus norvegicus" /db_xref="taxon:10116" Region 1..123 /region_name="Domain 1" /note="NCBI Domains" Region 2..319 /region_name="BET4" /note="Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]; COG5536" /db_xref="CDD:227823" SecStr 20..42 /sec_str_type="helix" /note="helix 1" SecStr 48..57 /sec_str_type="helix" /note="helix 2" SecStr 65..80 /sec_str_type="helix" /note="helix 3" SecStr 83..103 /sec_str_type="helix" /note="helix 4" SecStr 108..120 /sec_str_type="helix" /note="helix 5" SecStr 126..139 /sec_str_type="helix" /note="helix 6" SecStr 144..157 /sec_str_type="helix" /note="helix 7" Region 160..243 /region_name="Domain 2" /note="NCBI Domains" SecStr 161..174 /sec_str_type="helix" /note="helix 8" SecStr 179..191 /sec_str_type="helix" /note="helix 9" SecStr 206..222 /sec_str_type="helix" /note="helix 10" SecStr 228..238 /sec_str_type="helix" /note="helix 11" Region 244..331 /region_name="Domain 3" /note="NCBI Domains" SecStr 248..268 /sec_str_type="helix" /note="helix 12" SecStr 273..285 /sec_str_type="helix" /note="helix 13" SecStr 291..305 /sec_str_type="helix" /note="helix 14" SecStr 309..328 /sec_str_type="helix" /note="helix 15" ORIGIN 1 hmhgrlkvkt seeqaeakrl ereqklklyq satqavfqkr qageldesvl eltsqilgan 61 pdfatlwncr revlqhlete kspeesaalv kaelgflesc lrvnpksygt whhrcwllsr 121 lpepnwarel elcarflead ernfhcwdyr rfvaaqaava paeelaftds litrnfsnys 181 swhyrscllp qlhpqpdsgp qgrlpenvll kelelvqnaf ftdpndqsaw fyhrwllgag 241 sgrcelsvek stvlqseles ckelqelepe nkwclltiil lmraldplly eketlqyfst 301 lkavdpmraa ylddlrskfl lensvlkmey a //
Whole sequence Selected region from: to:
Conserved Domains
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