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Chain A, Geranylgeranyl transferase type-2 subunit alpha

PDB: 3HXC_A

Identical Proteins FASTA Graphics 

LOCUS       3HXC_A                   331 aa            linear   ROD 21-FEB-2024
DEFINITION  Chain A, Geranylgeranyl transferase type-2 subunit alpha.
ACCESSION   3HXC_A
VERSION     3HXC_A
DBSOURCE    pdb: molecule 3HXC, chain A, release Feb 21, 2024;
            deposition: Jun 20, 2009;
            class: TRANSFERASE;
            source: Mmdb_id: 76591, Pdb_id 1: 3HXC;
            Exp. method: X-ray Diffraction.
KEYWORDS    .
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Tan,K.T., Guiu-Rozas,E., Bon,R.S., Guo,Z., Delon,C., Wetzel,S.,
            Arndt,S., Alexandrov,K., Waldmann,H., Goody,R.S., Wu,Y.W. and
            Blankenfeldt,W.
  TITLE     Design, synthesis, and characterization of peptide-based rab
            geranylgeranyl transferase inhibitors
  JOURNAL   J Med Chem 52 (24), 8025-8037 (2009)
   PUBMED   19894725
REFERENCE   2  (residues 1 to 331)
  AUTHORS   Guo,Z., Alexandrov,K., Waldmann,H., Goody,R.S. and Blankenfeldt,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-2009)
COMMENT     Engineered RabGGTase in complex with a peptidomimetic inhibitor
            (compound 8).
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
     Region          1..123
                     /region_name="Domain 1"
                     /note="NCBI Domains"
     Region          2..319
                     /region_name="BET4"
                     /note="Protein prenyltransferase, alpha subunit
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5536"
                     /db_xref="CDD:227823"
     SecStr          20..42
                     /sec_str_type="helix"
                     /note="helix 1"
     SecStr          48..57
                     /sec_str_type="helix"
                     /note="helix 2"
     SecStr          65..80
                     /sec_str_type="helix"
                     /note="helix 3"
     SecStr          83..103
                     /sec_str_type="helix"
                     /note="helix 4"
     SecStr          108..120
                     /sec_str_type="helix"
                     /note="helix 5"
     SecStr          126..139
                     /sec_str_type="helix"
                     /note="helix 6"
     SecStr          144..157
                     /sec_str_type="helix"
                     /note="helix 7"
     Region          160..243
                     /region_name="Domain 2"
                     /note="NCBI Domains"
     SecStr          161..174
                     /sec_str_type="helix"
                     /note="helix 8"
     SecStr          179..191
                     /sec_str_type="helix"
                     /note="helix 9"
     SecStr          206..222
                     /sec_str_type="helix"
                     /note="helix 10"
     SecStr          228..238
                     /sec_str_type="helix"
                     /note="helix 11"
     Region          244..331
                     /region_name="Domain 3"
                     /note="NCBI Domains"
     SecStr          248..268
                     /sec_str_type="helix"
                     /note="helix 12"
     SecStr          273..285
                     /sec_str_type="helix"
                     /note="helix 13"
     SecStr          291..305
                     /sec_str_type="helix"
                     /note="helix 14"
     SecStr          309..328
                     /sec_str_type="helix"
                     /note="helix 15"
ORIGIN      
        1 hmhgrlkvkt seeqaeakrl ereqklklyq satqavfqkr qageldesvl eltsqilgan
       61 pdfatlwncr revlqhlete kspeesaalv kaelgflesc lrvnpksygt whhrcwllsr
      121 lpepnwarel elcarflead ernfhcwdyr rfvaaqaava paeelaftds litrnfsnys
      181 swhyrscllp qlhpqpdsgp qgrlpenvll kelelvqnaf ftdpndqsaw fyhrwllgag
      241 sgrcelsvek stvlqseles ckelqelepe nkwclltiil lmraldplly eketlqyfst
      301 lkavdpmraa ylddlrskfl lensvlkmey a
//
1..123
/region_name="Domain 1"
/note="NCBI Domains"
Feature 3HXC_A : 1 segment
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