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Goblet cell carcinoma

MedGen UID:
60007
Concept ID:
C0205695
Neoplastic Process
Synonym: Appendix goblet cell carcinoid
SNOMED CT: Mucocarcinoid tumor, malignant (31396002); Goblet cell carcinoid (31396002); Mucocarcinoid tumor (31396002); Mucinous carcinoid (31396002); Goblet cell adenocarcinoma (31396002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018017
Orphanet: ORPHA329984

Definition

Goblet cell carcinoma (GCC) is an aggressive type of endocrine tumor of the appendix (see this term) presenting equally in males and females in the fifth decade of life and manifesting with a palpable mass and abdominal pain or acute appendicitis. Metastasis to the ovaries, peritoneum or right colon has usually already occurred in half of patients at the time of diagnosis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGoblet cell carcinoma

Professional guidelines

PubMed

Wang G, Li Q, Chen W
BMC Cancer 2021 Jul 6;21(1):778. doi: 10.1186/s12885-021-08502-3. PMID: 34225672Free PMC Article
Madsen AH, Ladekarl M, Villadsen GE, Grønbæk H, Sørensen MM, Stribolt K, Verwaal VJ, Iversen LH
Ann Surg Oncol 2018 Feb;25(2):422-430. Epub 2017 Dec 6 doi: 10.1245/s10434-017-6272-x. PMID: 29214450
Plöckinger U, Couvelard A, Falconi M, Sundin A, Salazar R, Christ E, de Herder WW, Gross D, Knapp WH, Knigge UP, Kulke MH, Pape UF; Frascati Consensus Conference participants
Neuroendocrinology 2008;87(1):20-30. Epub 2007 Oct 11 doi: 10.1159/000109876. PMID: 17934252

Recent clinical studies

Etiology

Ricci C, Campana D, Ingaldi C, Lamberti G, Alberici L, Tateo V, Castagna G, Ricco G, Calderaro F, Malvi D, Rosini F, Casadei R
Langenbecks Arch Surg 2023 Jan 25;408(1):65. doi: 10.1007/s00423-023-02791-x. PMID: 36695921Free PMC Article
Mercier F, Passot G, Bonnot PE, Cashin P, Ceelen W, Decullier E, Villeneuve L, Walter T, Levine EA, Glehen O; PSOGI Working Group; BIG-RENAPE Working Group
World J Surg 2022 Jun;46(6):1336-1343. Epub 2022 Mar 13 doi: 10.1007/s00268-022-06498-w. PMID: 35286418
Mikaeel RR, Young JP, Tapia Rico G, Hewett PJ, Hardingham JE, Uylaki W, Horsnell M, Price TJ
Crit Rev Clin Lab Sci 2021 Sep;58(6):369-384. Epub 2021 Feb 11 doi: 10.1080/10408363.2021.1881756. PMID: 33569997
Zakka K, Williamson S, Jiang R, Reid MD, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF, Akce M
Surg Oncol 2021 Mar;36:120-129. Epub 2020 Dec 10 doi: 10.1016/j.suronc.2020.12.003. PMID: 33360118
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592

Diagnosis

Mutlu AU, Aytaç E, Gülmez M, Erdamar S, Özer L
Front Immunol 2023;14:1160586. Epub 2023 Jul 7 doi: 10.3389/fimmu.2023.1160586. PMID: 37483589Free PMC Article
Lin J, Yu T, Wang M, Wang J, Li J
Front Immunol 2022;13:1001264. Epub 2023 Jan 4 doi: 10.3389/fimmu.2022.1001264. PMID: 36685551Free PMC Article
Mikaeel RR, Young JP, Tapia Rico G, Hewett PJ, Hardingham JE, Uylaki W, Horsnell M, Price TJ
Crit Rev Clin Lab Sci 2021 Sep;58(6):369-384. Epub 2021 Feb 11 doi: 10.1080/10408363.2021.1881756. PMID: 33569997
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Imam R, Imam A, Atlan K, Mintz Y, Khoury T, Grozinsky-Galsberg S, Oleinikov K, Pikarsky AJ, Khalaileh A
Pathol Res Pract 2020 Sep;216(9):153092. Epub 2020 Jun 27 doi: 10.1016/j.prp.2020.153092. PMID: 32825959

Therapy

Mercier F, Passot G, Bonnot PE, Cashin P, Ceelen W, Decullier E, Villeneuve L, Walter T, Levine EA, Glehen O; PSOGI Working Group; BIG-RENAPE Working Group
World J Surg 2022 Jun;46(6):1336-1343. Epub 2022 Mar 13 doi: 10.1007/s00268-022-06498-w. PMID: 35286418
Zakka K, Williamson S, Jiang R, Reid MD, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF, Akce M
Surg Oncol 2021 Mar;36:120-129. Epub 2020 Dec 10 doi: 10.1016/j.suronc.2020.12.003. PMID: 33360118
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Zambrano-Vera K, Sardi A, Munoz-Zuluaga C, Studeman K, Nieroda C, Sittig M, King MC, Sipok A, Gushchin V
Ann Surg Oncol 2020 Jan;27(1):179-187. Epub 2019 Oct 23 doi: 10.1245/s10434-019-07932-5. PMID: 31646450
Enomoto LM, Choudry MH, Bartlett DL, Totin L, Mann GN, Skitzki JJ, Perry KC, Votanopoulos KI, Levine EA, Shen P
Ann Surg Oncol 2020 Jan;27(1):107-114. Epub 2019 Jul 31 doi: 10.1245/s10434-019-07634-y. PMID: 31368017

Prognosis

Lin J, Yu T, Wang M, Wang J, Li J
Front Immunol 2022;13:1001264. Epub 2023 Jan 4 doi: 10.3389/fimmu.2022.1001264. PMID: 36685551Free PMC Article
Mercier F, Passot G, Bonnot PE, Cashin P, Ceelen W, Decullier E, Villeneuve L, Walter T, Levine EA, Glehen O; PSOGI Working Group; BIG-RENAPE Working Group
World J Surg 2022 Jun;46(6):1336-1343. Epub 2022 Mar 13 doi: 10.1007/s00268-022-06498-w. PMID: 35286418
Zakka K, Williamson S, Jiang R, Reid MD, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF, Akce M
Surg Oncol 2021 Mar;36:120-129. Epub 2020 Dec 10 doi: 10.1016/j.suronc.2020.12.003. PMID: 33360118
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Zhang K, Meyerson C, Kassardjian A, Westbrook LM, Zheng W, Wang HL
Adv Anat Pathol 2019 Mar;26(2):75-83. doi: 10.1097/PAP.0000000000000222. PMID: 30601149

Clinical prediction guides

Mercier F, Passot G, Bonnot PE, Cashin P, Ceelen W, Decullier E, Villeneuve L, Walter T, Levine EA, Glehen O; PSOGI Working Group; BIG-RENAPE Working Group
World J Surg 2022 Jun;46(6):1336-1343. Epub 2022 Mar 13 doi: 10.1007/s00268-022-06498-w. PMID: 35286418
Prieto-Nieto MI, Pastor D, Rodríguez-Cobos J, Pérez JP, Méndez C, Palacios E, Arranz-Alvarez M, Santos-López J, Cano-Vega M, Viñal D, Rodríguez N, Domínguez G
Clin Transl Oncol 2019 Oct;21(10):1432-1439. doi: 10.1007/s12094-019-02091-1. PMID: 31025168
Wen KW, Hale G, Shafizadeh N, Hosseini M, Huang A, Kakar S
Hum Pathol 2017 Jul;65:187-193. Epub 2017 May 24 doi: 10.1016/j.humpath.2017.05.012. PMID: 28551326
Rodt AP, Svarrer RO, Iversen LH
World J Surg Oncol 2013 Sep 16;11:232. doi: 10.1186/1477-7819-11-232. PMID: 24040889Free PMC Article

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