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Adenocarcinoid tumor

MedGen UID:: 83124
•Concept ID:: C0334302
•: Neoplastic Process

Synonym:	Combined carcinoid and adenocarcinoma
SNOMED CT:	Mixed carcinoid-adenocarcinoma (51465000); Mixed adenoneuroendocrine carcinoma (51465000); MANEC - mixed adenoneuroendocrine carcinoma (51465000); Composite carcinoid (51465000); Combined carcinoid and adenocarcinoma (51465000)

Monarch Initiative:	MONDO:0021659

Definition

A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells with morphologic and immunohistochemical characteristics of carcinoid tumor and malignant glandular cells. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAdenocarcinoid tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Epithelial neoplasm
        Carcinoma
        Adenocarcinoid tumor
        Gallbladder Goblet Cell Adenocarcinoma
        Goblet cell carcinoma

Professional guidelines

PubMed

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.

Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496 Free PMC Article

Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.

Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015

Management of rectal cancers in relation to treatment guidelines: a population-based study comparing Italian and French patients.

Minicozzi P, Bouvier AM, Faivre J, Sant M; Study working group
Dig Liver Dis 2014 Jul;46(7):645-51. Epub 2014 Apr 18 doi: 10.1016/j.dld.2014.03.009. PMID: 24746280

See all (5)

Recent clinical studies

Etiology

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.

Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132 Free PMC Article

Mixed adenoneuroendocrine carcinoma of the colon and rectum.

Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510

Pathology of gastric cancer and its precursor lesions.

Yakirevich E, Resnick MB
Gastroenterol Clin North Am 2013 Jun;42(2):261-84. Epub 2013 Mar 1 doi: 10.1016/j.gtc.2013.01.004. PMID: 23639640

Adenocarcinoid tumor of the extrahepatic biliary tract.

Costantini M, Montalti R, Rossi G, Luisa L, Masetti M, Di Benedetto F, Giorgio G
Int J Surg Pathol 2008 Oct;16(4):455-7. Epub 2008 May 14 doi: 10.1177/1066896908315816. PMID: 18480386

Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.

Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936

See all (36)

Diagnosis

Perianal Goblet Cell Carcinoid With Pagetoid Spread.

Grunes D, Kim MK, Chessin DB, Yaeger RD, Ward SC
Int J Surg Pathol 2019 Oct;27(7):788-791. Epub 2019 May 13 doi: 10.1177/1066896919845478. PMID: 31079516 Free PMC Article

Mixed adenoneuroendocrine carcinoma of the colon and rectum.

Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510

Mixed adenoneuroendocrine carcinoma: A review of pathologic characteristics.

Brathwaite SA, Smith SM, Wai L, Frankel W, Hays J, Yearsley MM, Abdel-Misih S
Hum Pathol 2018 Mar;73:184-191. Epub 2017 Dec 27 doi: 10.1016/j.humpath.2017.12.009. PMID: 29288693

A case of advanced rectal adenocarcinoid tumor with long-term survival.

Wakahara T, Yamamoto S, Fujita S, Akasu T, Onouchi S, Moriya Y
Jpn J Clin Oncol 2010 Jul;40(7):690-3. Epub 2010 Mar 25 doi: 10.1093/jjco/hyq033. PMID: 20338947

Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.

Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

See all (57)

Therapy

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.

Clinicopathological and Prognostic Evaluations of Mixed Adenoneuroendocrine Carcinoma of the Colon and Rectum: A Case-Matched Study.

Watanabe J, Suwa Y, Ota M, Ishibe A, Masui H, Nagahori K, Tsuura Y, Endo I
Dis Colon Rectum 2016 Dec;59(12):1160-1167. doi: 10.1097/DCR.0000000000000702. PMID: 27824701

Does prior percutaneous endoscopic gastrostomy alter post-operative outcome after esophagectomy.

Bhatti AB, Rizvi FH, Waheed A, Raza SH, Syed AA, Khattak S, Aasim Yusuf M
World J Surg 2015 Feb;39(2):441-5. doi: 10.1007/s00268-014-2812-8. PMID: 25270346

Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.

Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936

Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.

Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

See all (20)

Prognosis

Perianal Goblet Cell Carcinoid With Pagetoid Spread.

Grunes D, Kim MK, Chessin DB, Yaeger RD, Ward SC
Int J Surg Pathol 2019 Oct;27(7):788-791. Epub 2019 May 13 doi: 10.1177/1066896919845478. PMID: 31079516 Free PMC Article

Mixed adenoneuroendocrine carcinoma of the colon and rectum.

Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510

Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.

Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936

Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.

Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Adenocarcinoid tumor of the ampulla of Vater.

Alex WR, Auerbach HE, Pezzi CM
Am Surg 1998 Apr;64(4):355-9. PMID: 9544149

See all (45)

Clinical prediction guides

Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Versus Surgery Without HIPEC for Goblet-Cell Carcinoids and Mixed Adenoneuroendocrine Carcinomas: Propensity Score-Matched Analysis of Centers in the Netherlands and Belgium.

Sluiter NR, van der Bilt JD, Croll DMR, Vriens MR, de Hingh IHJT, Hemmer P, Aalbers AGJ, Bremers AJA, Ceelen W, D'Hoore A, Schoonmade LJ, Coupé V, Verheul H, Kazemier G, Tuynman JB; Dutch Peritoneal Oncology Group
Clin Colorectal Cancer 2020 Sep;19(3):e87-e99. Epub 2020 Jan 30 doi: 10.1016/j.clcc.2020.01.002. PMID: 32651131

High neuroendocrine component is a factor for poor prognosis in gastrointestinal high-grade malignant mixed adenoneuroendocrine neoplasms.

Chen MH, Kuo YJ, Yeh YC, Lin YC, Tzeng CH, Liu CY, Chang PM, Chen MH, Jeng YM, Chao Y
J Chin Med Assoc 2015 Aug;78(8):454-9. Epub 2015 May 19 doi: 10.1016/j.jcma.2015.04.002. PMID: 26002564

Discordant histology of primary appendiceal adenocarcinoid neoplasms with peritoneal dissemination.

Yan TD, Brun EA, Sugarbaker PH
Ann Surg Oncol 2008 May;15(5):1440-6. Epub 2008 Feb 26 doi: 10.1245/s10434-007-9754-4. PMID: 18299936

Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.

Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S
Eur J Obstet Gynecol Reprod Biol 2001 Jul;97(1):90-5. doi: 10.1016/s0301-2115(00)00503-0. PMID: 11435017

Crypt cell carcinoma of the appendix (so-called adenocarcinoid tumor).

Isaacson P
Am J Surg Pathol 1981 Apr;5(3):213-24. doi: 10.1097/00000478-198104000-00001. PMID: 7235117

See all (23)

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.

Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615

MicroRNA-223 in gastrointestinal cancers: A systematic review and diagnostic meta-analysis.

Aalami AH, Abdeahad H, Mesgari M, Sahebkar A
Eur J Clin Invest 2021 Feb;51(2):e13448. Epub 2020 Dec 5 doi: 10.1111/eci.13448. PMID: 33244751

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.

Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496 Free PMC Article

See all (4)

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Adenocarcinoid tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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