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Nasopharyngeal carcinoma

MedGen UID:
419909
Concept ID:
C2931822
Neoplastic Process
Synonym: Nasopharyngeal carcinoma, somatic
SNOMED CT: Nasopharyngeal carcinoma (449248000)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Gene (location): TP53 (17p13.1)
 
Monarch Initiative: MONDO:0015459
OMIM®: 607107
Orphanet: ORPHA150

Definition

Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated (Tse et al., 2009). Genetic Heterogeneity of Susceptibility to Nasopharyngeal Carcinoma NPCA1 maps to chromosome 4p. NPCA2 (161550) maps to chromosome 6p21. NPCA3 (617075) is associated with variation in the MST1R gene (600168) on chromosome 3p21. Somatic mutations have been found in the TP53 gene (191170) in nasopharyngeal carcinoma tumors. [from OMIM]

Clinical features

From HPO
Nasopharyngeal neoplasm
MedGen UID:
6526
Concept ID:
C0027439
Neoplastic Process
A benign or malignant neoplasm affecting the nasopharynx. Representative examples of benign neoplasms include angiofibroma and squamous papilloma. Representative examples of malignant neoplasms include keratinizing squamous cell carcinoma and nonkeratinizing carcinoma.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasopharyngeal carcinoma
Follow this link to review classifications for Nasopharyngeal carcinoma in Orphanet.

Professional guidelines

PubMed

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Lv J, Wei Y, Yin JH, Chen YP, Zhou GQ, Wei C, Liang XY, Zhang Y, Zhang CJ, He SW, He QM, Huang ZL, Guan JL, Shen JY, Li XM, Li JY, Li WF, Tang LL, Mao YP, Guo R, Sun R, Zheng YH, Zhou WW, Xiong KX, Wang SQ, Jin X, Liu N, Li GB, Kuang DM, Sun Y, Ma J
Nat Med 2023 Jun;29(6):1424-1436. Epub 2023 Jun 6 doi: 10.1038/s41591-023-02369-6. PMID: 37280275
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Su ZY, Siak PY, Lwin YY, Cheah SC
Cancer Metastasis Rev 2024 Sep;43(3):919-939. Epub 2024 Mar 2 doi: 10.1007/s10555-024-10176-9. PMID: 38430391
Wang Z, Fang M, Zhang J, Tang L, Zhong L, Li H, Cao R, Zhao X, Liu S, Zhang R, Xie X, Mai H, Qiu S, Tian J, Dong D
IEEE Rev Biomed Eng 2024;17:118-135. Epub 2024 Jan 12 doi: 10.1109/RBME.2023.3269776. PMID: 37097799
Liu Y, Wen J, Huang W
Clin Chim Acta 2021 Dec;523:355-364. Epub 2021 Oct 16 doi: 10.1016/j.cca.2021.10.013. PMID: 34666030
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J
Lancet 2019 Jul 6;394(10192):64-80. Epub 2019 Jun 6 doi: 10.1016/S0140-6736(19)30956-0. PMID: 31178151

Diagnosis

Huang H, Yao Y, Deng X, Huang Z, Chen Y, Wang Z, Hong H, Huang H, Lin T
Int J Oncol 2023 Aug;63(2) Epub 2023 Jul 7 doi: 10.3892/ijo.2023.5545. PMID: 37417358Free PMC Article
Guan S, Wei J, Huang L, Wu L
Eur J Med Chem 2020 Dec 1;207:112758. Epub 2020 Aug 20 doi: 10.1016/j.ejmech.2020.112758. PMID: 32858472
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J
Lancet 2019 Jul 6;394(10192):64-80. Epub 2019 Jun 6 doi: 10.1016/S0140-6736(19)30956-0. PMID: 31178151
Chua MLK, Wee JTS, Hui EP, Chan ATC
Lancet 2016 Mar 5;387(10022):1012-1024. Epub 2015 Aug 28 doi: 10.1016/S0140-6736(15)00055-0. PMID: 26321262

Therapy

Mai HQ, Chen QY, Chen D, Hu C, Yang K, Wen J, Li J, Shi Y, Jin F, Xu R, Pan J, Qu S, Li P, Hu C, Liu YC, Jiang Y, He X, Wang HM, Lim WT, Liao W, He X, Chen X, Wang S, Yuan X, Li Q, Lin X, Jing S, Chen Y, Lu Y, Hsieh CY, Yang MH, Yen CJ, Samol J, Luo X, Wang X, Tang X, Feng H, Yao S, Keegan P, Xu RH
JAMA 2023 Nov 28;330(20):1961-1970. doi: 10.1001/jama.2023.20181. PMID: 38015220Free PMC Article
Huang H, Yao Y, Deng X, Huang Z, Chen Y, Wang Z, Hong H, Huang H, Lin T
Int J Oncol 2023 Aug;63(2) Epub 2023 Jul 7 doi: 10.3892/ijo.2023.5545. PMID: 37417358Free PMC Article
Lv J, Wei Y, Yin JH, Chen YP, Zhou GQ, Wei C, Liang XY, Zhang Y, Zhang CJ, He SW, He QM, Huang ZL, Guan JL, Shen JY, Li XM, Li JY, Li WF, Tang LL, Mao YP, Guo R, Sun R, Zheng YH, Zhou WW, Xiong KX, Wang SQ, Jin X, Liu N, Li GB, Kuang DM, Sun Y, Ma J
Nat Med 2023 Jun;29(6):1424-1436. Epub 2023 Jun 6 doi: 10.1038/s41591-023-02369-6. PMID: 37280275
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Zhang Y, Chen L, Hu GQ, Zhang N, Zhu XD, Yang KY, Jin F, Shi M, Chen YP, Hu WH, Cheng ZB, Wang SY, Tian Y, Wang XC, Sun Y, Li JG, Li WF, Li YH, Tang LL, Mao YP, Zhou GQ, Sun R, Liu X, Guo R, Long GX, Liang SQ, Li L, Huang J, Long JH, Zang J, Liu QD, Zou L, Su QF, Zheng BM, Xiao Y, Guo Y, Han F, Mo HY, Lv JW, Du XJ, Xu C, Liu N, Li YQ, Chua MLK, Xie FY, Sun Y, Ma J
N Engl J Med 2019 Sep 19;381(12):1124-1135. Epub 2019 May 31 doi: 10.1056/NEJMoa1905287. PMID: 31150573

Prognosis

Lei S, Chen L, Ji P, Li K, Li Q, Huang C, Wang G, Ma J, Guo R, Tang L
Oral Oncol 2024 Aug;155:106891. Epub 2024 Jun 14 doi: 10.1016/j.oraloncology.2024.106891. PMID: 38878356
Su ZY, Siak PY, Lwin YY, Cheah SC
Cancer Metastasis Rev 2024 Sep;43(3):919-939. Epub 2024 Mar 2 doi: 10.1007/s10555-024-10176-9. PMID: 38430391
Xiao XT, Wu YS, Chen YP, Liu X, Guo R, Tang LL, Ma J, Li WF
Cancer Med 2023 Jan;12(2):1399-1408. Epub 2022 Jul 13 doi: 10.1002/cam4.5020. PMID: 35822664Free PMC Article
Byard RW
J Forensic Sci 2016 Sep;61(5):1244-9. Epub 2016 Jun 10 doi: 10.1111/1556-4029.13119. PMID: 27282512
Vokes EE, Liebowitz DN, Weichselbaum RR
Lancet 1997 Oct 11;350(9084):1087-91. doi: 10.1016/S0140-6736(97)07269-3. PMID: 10213566

Clinical prediction guides

Petit C, Lee A, Ma J, Lacas B, Ng WT, Chan ATC, Hong RL, Chen MY, Chen L, Li WF, Huang PY, Tan T, Ngan RKC, Zhu G, Mai HQ, Hui EP, Fountzilas G, Zhang L, Carmel A, Kwong DLW, Moon J, Bourhis J, Auperin A, Pignon JP, Blanchard P; MAC-NPC Collaborative Group
Lancet Oncol 2023 Jun;24(6):611-623. doi: 10.1016/S1470-2045(23)00163-8. PMID: 37269842
Tang LL, Guo R, Zhang N, Deng B, Chen L, Cheng ZB, Huang J, Hu WH, Huang SH, Luo WJ, Liang JH, Zheng YM, Zhang F, Mao YP, Li WF, Zhou GQ, Liu X, Chen YP, Xu C, Lin L, Liu Q, Du XJ, Zhang Y, Sun Y, Ma J
JAMA 2022 Aug 23;328(8):728-736. doi: 10.1001/jama.2022.13997. PMID: 35997729Free PMC Article
He YQ, Wang TM, Ji M, Mai ZM, Tang M, Wang R, Zhou Y, Zheng Y, Xiao R, Yang D, Wu Z, Deng C, Zhang J, Xue W, Dong S, Zhan J, Cai Y, Li F, Wu B, Liao Y, Zhou T, Zheng M, Jia Y, Li D, Cao L, Yuan L, Zhang W, Luo L, Tong X, Wu Y, Li X, Zhang P, Zheng X, Zhang S, Hu Y, Qin W, Deng B, Liang X, Fan P, Feng Y, Song J, Xie SH, Chang ET, Zhang Z, Huang G, Xu M, Feng L, Jin G, Bei J, Cao S, Liu Q, Kozlakidis Z, Mai H, Sun Y, Ma J, Hu Z, Liu J, Lung ML, Adami HO, Shen H, Ye W, Lam TH, Zeng YX, Jia WH
Nat Commun 2022 Apr 12;13(1):1966. doi: 10.1038/s41467-022-29570-4. PMID: 35414057Free PMC Article
Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, Zhang Y, Wen X, Zhang J, Wang YQ, Zhang PP, Sun Y, Yun JP, Zeng J, Li L, Liu LZ, Liu N, Ma J
Lancet Oncol 2018 Mar;19(3):382-393. Epub 2018 Feb 7 doi: 10.1016/S1470-2045(18)30080-9. PMID: 29428165
Petersson F
Semin Diagn Pathol 2015 Jan;32(1):54-73. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.021. PMID: 25769204

Recent systematic reviews

Zhao BY, Hirayama S, Goss D, Zhao Y, Faden DL
Oral Oncol 2024 Dec;159:107057. Epub 2024 Oct 8 doi: 10.1016/j.oraloncology.2024.107057. PMID: 39383626
Wang D, Liao M, Wu J, Luo W, Qi S, Liu B, Li J
Head Neck 2023 Feb;45(2):503-520. Epub 2022 Nov 24 doi: 10.1002/hed.27253. PMID: 36420965
Gorolay VV, Niles NN, Huo YR, Ahmadi N, Hanneman K, Thompson E, Chan MV
Neuroradiology 2022 Aug;64(8):1471-1481. Epub 2022 Apr 30 doi: 10.1007/s00234-022-02941-w. PMID: 35499636Free PMC Article
Chen YP, Ismaila N, Chua MLK, Colevas AD, Haddad R, Huang SH, Wee JTS, Whitley AC, Yi JL, Yom SS, Chan ATC, Hu CS, Lang JY, Le QT, Lee AWM, Lee N, Lin JC, Ma B, Morgan TJ, Shah J, Sun Y, Ma J
J Clin Oncol 2021 Mar 1;39(7):840-859. Epub 2021 Jan 6 doi: 10.1200/JCO.20.03237. PMID: 33405943
Lee AW, Ng WT, Pan JJ, Chiang CL, Poh SS, Choi HC, Ahn YC, AlHussain H, Corry J, Grau C, Grégoire V, Harrington KJ, Hu CS, Kwong DL, Langendijk JA, Le QT, Lee NY, Lin JC, Lu TX, Mendenhall WM, O'Sullivan B, Ozyar E, Peters LJ, Rosenthal DI, Sanguineti G, Soong YL, Tao Y, Yom SS, Wee JT
Int J Radiat Oncol Biol Phys 2019 Nov 1;105(3):567-580. Epub 2019 Jul 2 doi: 10.1016/j.ijrobp.2019.06.2540. PMID: 31276776

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

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