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Non-Mendelian inheritance

MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Synonym: Multifactorial inheritance
 
HPO: HP:0001426
Orphanet: ORPHA409931

Definition

A mode of inheritance that depends on genetic determinants in more than one gene. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Mendelian inheritance

Professional guidelines

PubMed

Inconsistencies between prenatal diagnostic and genetic testing laboratories on variant validation of rare monogenic diseases.
Lin L, Zhang Y, Pan H, Wang J, Qi Y, Ma Y
Prenat Diagn 2024 Aug;44(9):1053-1061. Epub 2024 Jun 19 doi: 10.1002/pd.6628. PMID: 38898598
Genetic and epigenetic regulation on the transcription of GABRB2: Genotype-dependent hydroxymethylation and methylation alterations in schizophrenia.
Zong L, Zhou L, Hou Y, Zhang L, Jiang W, Zhang W, Wang L, Luo X, Wang S, Deng C, Peng Z, Li S, Hu J, Zhao H, Zhao C
J Psychiatr Res 2017 May;88:9-17. Epub 2016 Dec 28 doi: 10.1016/j.jpsychires.2016.12.019. PMID: 28063323
Identifying pathogenic genetic background of simplex or multiplex retinitis pigmentosa patients: a large scale mutation screening study.
Jin ZB, Mandai M, Yokota T, Higuchi K, Ohmori K, Ohtsuki F, Takakura S, Itabashi T, Wada Y, Akimoto M, Ooto S, Suzuki T, Hirami Y, Ikeda H, Kawagoe N, Oishi A, Ichiyama S, Takahashi M, Yoshimura N, Kosugi S
J Med Genet 2008 Jul;45(7):465-72. Epub 2008 Feb 29 doi: 10.1136/jmg.2007.056416. PMID: 18310263

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