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Oligogenic inheritance

MedGen UID:
253949
•Concept ID:
C1136026
•
Genetic Function
Synonym: oligogenic
 
HPO: HP:0010983
Orphanet: ORPHA409936

Definition

A type of multifactorial inheritance governed by the simultaneous action of a few gene loci. It is recommended this term be used for traits governed by three loci, although it is noted that usage of this term in the literature is not uniform. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOligogenic inheritance

Professional guidelines

PubMed

Clinical implications of genetic testing in familial intermediate and late-onset colorectal cancer.
Djursby M, Hansen TVO, Wadt KAW, Madsen MB, Berchtold LA, Lautrup CK, Markholt S, Jensen UB, Krogh LN, Lundsgaard M, Gerdes AM, Nilbert M, Therkildsen C
Hum Genet 2022 Dec;141(12):1925-1933. Epub 2022 Jul 29 doi: 10.1007/s00439-022-02470-9. PMID: 35904628
Genetics of hypogonadotropic Hypogonadism-Human and mouse genes, inheritance, oligogenicity, and genetic counseling.
Louden ED, Poch A, Kim HG, Ben-Mahmoud A, Kim SH, Layman LC
Mol Cell Endocrinol 2021 Aug 20;534:111334. Epub 2021 May 30 doi: 10.1016/j.mce.2021.111334. PMID: 34062169
Bardet-Biedl syndrome: Genetics, molecular pathophysiology, and disease management.
Priya S, Nampoothiri S, Sen P, Sripriya S
Indian J Ophthalmol 2016 Sep;64(9):620-627. doi: 10.4103/0301-4738.194328. PMID: 27853007Free PMC Article

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