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Penile Intraepithelial Neoplasia

MedGen UID:
91118
•Concept ID:
C0347180
•
Neoplastic Process
Synonyms: Penile intraepithelial neoplasia; PIN - Penile intraepithelial neoplasia
SNOMED CT: Penile intraepithelial neoplasia (255148008); PIN - Penile intraepithelial neoplasia (255148008)

Definition

A precancerous neoplastic lesion that arises from the penis. It is characterized by dysplastic changes of the squamous epithelium with an intact basement membrane. [from NCI]

Professional guidelines

PubMed

2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
The management of penile intraepithelial neoplasia (PeIN): clinical and histological features and treatment of 345 patients and a review of the literature.
Kravvas G, Ge L, Ng J, Shim TN, Doiron PR, Watchorn R, Kentley J, Panou E, Dinneen M, Freeman A, Jameson C, Haider A, Francis N, Minhas S, Alnajjar H, Muneer A, Bunker CB
J Dermatolog Treat 2022 Mar;33(2):1047-1062. Epub 2020 Aug 6 doi: 10.1080/09546634.2020.1800574. PMID: 32705920
The Role of Human Papilloma Virus in Penile Carcinogenesis and Preneoplastic Lesions: A Potential Target for Vaccination and Treatment Strategies.
Diorio GJ, Giuliano AR
Urol Clin North Am 2016 Nov;43(4):419-425. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.003. PMID: 27717428

Recent clinical studies

Etiology

2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Photodynamic therapy combined with circumcision for the treatment of penile intraepithelial neoplasia.
Gao X, Wu L, Chen M, Su J, Zhao S
Photodiagnosis Photodyn Ther 2020 Sep;31:101894. Epub 2020 Jun 23 doi: 10.1016/j.pdpdt.2020.101894. PMID: 32590164
Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989
The Role of Human Papilloma Virus in Penile Carcinogenesis and Preneoplastic Lesions: A Potential Target for Vaccination and Treatment Strategies.
Diorio GJ, Giuliano AR
Urol Clin North Am 2016 Nov;43(4):419-425. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.003. PMID: 27717428

Diagnosis

Penile Intraepithelial Neoplasia: a Disease That Should Be Recognized.
Robles-Silva C, Hidalgo L, Vera-Kellet C
J Gen Intern Med 2023 Jul;38(9):2205-2206. Epub 2023 Mar 29 doi: 10.1007/s11606-023-08150-2. PMID: 36988868Free PMC Article
2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
Acquired lymphangioma circumscriptum in high-grade penile intraepithelial neoplasia.
Kreuter A, Oellig F, Kuntz T, Paschos A, Silling S, Akgül B, Wieland U
Int J STD AIDS 2021 Jan;32(1):86-88. Epub 2020 Oct 29 doi: 10.1177/0956462420951094. PMID: 33121365
Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989
A case of pigmented penile intraepithelial neoplasia: dermoscopic and clinicohistopathologic analysis.
Friedman BJ, Kohen LL
J Am Acad Dermatol 2015 Jan;72(1 Suppl):S71-2. doi: 10.1016/j.jaad.2014.09.039. PMID: 25500051

Therapy

2022 European guideline for the management of balanoposthitis.
Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
Incidence of penile intraepithelial neoplasia and treatment strategies in Sweden 2000-2019.
Kristiansen S, Torbrand C, Svensson Å, Forslund O, Bjartling C
BJU Int 2022 Jun;129(6):752-759. Epub 2022 Jan 24 doi: 10.1111/bju.15688. PMID: 35044047Free PMC Article
Photodynamic therapy combined with circumcision for the treatment of penile intraepithelial neoplasia.
Gao X, Wu L, Chen M, Su J, Zhao S
Photodiagnosis Photodyn Ther 2020 Sep;31:101894. Epub 2020 Jun 23 doi: 10.1016/j.pdpdt.2020.101894. PMID: 32590164
Imiquimod in the treatment of penile intraepithelial neoplasia: An update.
Deen K, Burdon-Jones D
Australas J Dermatol 2017 May;58(2):86-92. Epub 2016 Mar 8 doi: 10.1111/ajd.12466. PMID: 26952903
The Role of Human Papilloma Virus in Penile Carcinogenesis and Preneoplastic Lesions: A Potential Target for Vaccination and Treatment Strategies.
Diorio GJ, Giuliano AR
Urol Clin North Am 2016 Nov;43(4):419-425. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.003. PMID: 27717428

Prognosis

Pathology of Squamous Cell Carcinoma of the Penis: Back to Square One.
Sanchez DF, Oliveira P
Urol Clin North Am 2024 Aug;51(3):313-325. Epub 2024 Apr 12 doi: 10.1016/j.ucl.2024.03.003. PMID: 38925734
WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Incidence of penile intraepithelial neoplasia and treatment strategies in Sweden 2000-2019.
Kristiansen S, Torbrand C, Svensson Å, Forslund O, Bjartling C
BJU Int 2022 Jun;129(6):752-759. Epub 2022 Jan 24 doi: 10.1111/bju.15688. PMID: 35044047Free PMC Article
Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989
The Role of Human Papilloma Virus in Penile Carcinogenesis and Preneoplastic Lesions: A Potential Target for Vaccination and Treatment Strategies.
Diorio GJ, Giuliano AR
Urol Clin North Am 2016 Nov;43(4):419-425. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.003. PMID: 27717428

Clinical prediction guides

Penile intraepithelial neoplasia incidence, clinical classification, microenvironment and implications for imiquimod treatment.
Avitan O, Rafael T, Vreeburg M, Elst L, Bekers EM, Albersen M, Jordanova ES, Brouwer O
BJU Int 2024 Dec;134(6):881-889. Epub 2024 Jul 19 doi: 10.1111/bju.16473. PMID: 39030899
Pathology of Squamous Cell Carcinoma of the Penis: Back to Square One.
Sanchez DF, Oliveira P
Urol Clin North Am 2024 Aug;51(3):313-325. Epub 2024 Apr 12 doi: 10.1016/j.ucl.2024.03.003. PMID: 38925734
Incidence of penile intraepithelial neoplasia and incidence and survival of penile cancer in Denmark, 1997 to 2018.
Olesen TB, Sand FL, Aalborg GL, Munk C, Kjaer SK
Cancer Causes Control 2022 Jan;33(1):117-123. Epub 2021 Oct 26 doi: 10.1007/s10552-021-01510-5. PMID: 34698994
Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.
Issa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, Lucky M, Oliveira P, Lau M, Parnham A, Sangar V, Fankhauser CD
Eur Urol Focus 2022 May;8(3):829-832. Epub 2021 May 11 doi: 10.1016/j.euf.2021.04.026. PMID: 33994168
Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989

Recent systematic reviews

Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.
Issa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, Lucky M, Oliveira P, Lau M, Parnham A, Sangar V, Fankhauser CD
Eur Urol Focus 2022 May;8(3):829-832. Epub 2021 May 11 doi: 10.1016/j.euf.2021.04.026. PMID: 33994168
Prevalence of human papillomavirus DNA and p16(INK4a) in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis.
Olesen TB, Sand FL, Rasmussen CL, Albieri V, Toft BG, Norrild B, Munk C, Kjær SK
Lancet Oncol 2019 Jan;20(1):145-158. Epub 2018 Dec 17 doi: 10.1016/S1470-2045(18)30682-X. PMID: 30573285
Efficacy, effectiveness and safety of vaccination against human papillomavirus in males: a systematic review.
Harder T, Wichmann O, Klug SJ, van der Sande MAB, Wiese-Posselt M
BMC Med 2018 Jul 18;16(1):110. doi: 10.1186/s12916-018-1098-3. PMID: 30016957Free PMC Article
The management of penile intraepithelial neoplasia in genitourinary medicine.
Markos AR
Int J STD AIDS 2003 May;14(5):314-9. doi: 10.1258/095646203321605512. PMID: 12803938

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