U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic squamous cell carcinoma

MedGen UID:
90749
Concept ID:
C0334246
Neoplastic Process
Synonyms: Metastatic Squamous Cell Carcinoma; metastatic squamous cell carcinoma; Squamous cell carcinoma, metastatic
SNOMED CT: Squamous cell carcinoma, metastatic (64204000); Metastatic squamous cell carcinoma (64204000); Metastatic squamous cell carcinoma (403906006)
 
Monarch Initiative: MONDO:0044907

Definition

A carcinoma that arises from squamous cells and has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic squamous cell carcinoma

Professional guidelines

PubMed

Choi JDW, Shah D, El-Khoury T, Pathma-Nathan N, Toh JWT
Surg Oncol Clin N Am 2025 Jan;34(1):69-81. Epub 2024 Sep 10 doi: 10.1016/j.soc.2024.08.001. PMID: 39547770
Syed MI, Stewart M, Syed S, Dahill S, Adams C, McLellan DR, Clark LJ
J Laryngol Otol 2011 Jan;125(1):3-9. Epub 2010 Oct 18 doi: 10.1017/S0022215110002070. PMID: 20950510
Veness MJ
Australas Radiol 2005 Oct;49(5):365-76. doi: 10.1111/j.1440-1673.2005.01496.x. PMID: 16174174

Recent clinical studies

Etiology

Choi JDW, Shah D, El-Khoury T, Pathma-Nathan N, Toh JWT
Surg Oncol Clin N Am 2025 Jan;34(1):69-81. Epub 2024 Sep 10 doi: 10.1016/j.soc.2024.08.001. PMID: 39547770
Burtness B, Harrington KJ, Greil R, Soulières D, Tahara M, de Castro G Jr, Psyrri A, Basté N, Neupane P, Bratland Å, Fuereder T, Hughes BGM, Mesía R, Ngamphaiboon N, Rordorf T, Wan Ishak WZ, Hong RL, González Mendoza R, Roy A, Zhang Y, Gumuscu B, Cheng JD, Jin F, Rischin D; KEYNOTE-048 Investigators
Lancet 2019 Nov 23;394(10212):1915-1928. Epub 2019 Nov 1 doi: 10.1016/S0140-6736(19)32591-7. PMID: 31679945
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article
Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, Cheng JD, Chow LQ
Lancet Oncol 2016 Jul;17(7):956-965. Epub 2016 May 27 doi: 10.1016/S1470-2045(16)30066-3. PMID: 27247226
Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, Peyrade F, Benasso M, Vynnychenko I, De Raucourt D, Bokemeyer C, Schueler A, Amellal N, Hitt R
N Engl J Med 2008 Sep 11;359(11):1116-27. doi: 10.1056/NEJMoa0802656. PMID: 18784101

Diagnosis

Traeger L, Raju D
ANZ J Surg 2021 Jan;91(1-2):200-202. Epub 2020 Jun 4 doi: 10.1111/ans.16058. PMID: 32497387
Yokota T, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ogawa T, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R; Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group
Jpn J Clin Oncol 2020 Sep 28;50(10):1089-1096. doi: 10.1093/jjco/hyaa139. PMID: 32776100
Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, Cheng JD, Chow LQ
Lancet Oncol 2016 Jul;17(7):956-965. Epub 2016 May 27 doi: 10.1016/S1470-2045(16)30066-3. PMID: 27247226
Curry JL, Wojcik EM
Diagn Cytopathol 2003 Nov;29(5):270. doi: 10.1002/dc.10327. PMID: 14595794
Foley SJ, Pay A, Howell GP, Holt S
J R Army Med Corps 1995 Jun;141(2):102-4. doi: 10.1136/jramc-141-02-09. PMID: 7562734

Therapy

Kojima T, Shah MA, Muro K, Francois E, Adenis A, Hsu CH, Doi T, Moriwaki T, Kim SB, Lee SH, Bennouna J, Kato K, Shen L, Enzinger P, Qin SK, Ferreira P, Chen J, Girotto G, de la Fouchardiere C, Senellart H, Al-Rajabi R, Lordick F, Wang R, Suryawanshi S, Bhagia P, Kang SP, Metges JP; KEYNOTE-181 Investigators
J Clin Oncol 2020 Dec 10;38(35):4138-4148. Epub 2020 Oct 7 doi: 10.1200/JCO.20.01888. PMID: 33026938
Burtness B, Harrington KJ, Greil R, Soulières D, Tahara M, de Castro G Jr, Psyrri A, Basté N, Neupane P, Bratland Å, Fuereder T, Hughes BGM, Mesía R, Ngamphaiboon N, Rordorf T, Wan Ishak WZ, Hong RL, González Mendoza R, Roy A, Zhang Y, Gumuscu B, Cheng JD, Jin F, Rischin D; KEYNOTE-048 Investigators
Lancet 2019 Nov 23;394(10212):1915-1928. Epub 2019 Nov 1 doi: 10.1016/S0140-6736(19)32591-7. PMID: 31679945
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article
Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, Peyrade F, Benasso M, Vynnychenko I, De Raucourt D, Bokemeyer C, Schueler A, Amellal N, Hitt R
N Engl J Med 2008 Sep 11;359(11):1116-27. doi: 10.1056/NEJMoa0802656. PMID: 18784101
Vermorken JB, Trigo J, Hitt R, Koralewski P, Diaz-Rubio E, Rolland F, Knecht R, Amellal N, Schueler A, Baselga J
J Clin Oncol 2007 Jun 1;25(16):2171-7. doi: 10.1200/JCO.2006.06.7447. PMID: 17538161

Prognosis

Choi JDW, Shah D, El-Khoury T, Pathma-Nathan N, Toh JWT
Surg Oncol Clin N Am 2025 Jan;34(1):69-81. Epub 2024 Sep 10 doi: 10.1016/j.soc.2024.08.001. PMID: 39547770
Psyrri A, Fayette J, Harrington K, Gillison M, Ahn MJ, Takahashi S, Weiss J, Machiels JP, Baxi S, Vasilyev A, Karpenko A, Dvorkin M, Hsieh CY, Thungappa SC, Segura PP, Vynnychenko I, Haddad R, Kasper S, Mauz PS, Baker V, He P, Evans B, Wildsmith S, Olsson RF, Yovine A, Kurland JF, Morsli N, Seiwert TY; KESTREL Investigators
Ann Oncol 2023 Mar;34(3):262-274. Epub 2022 Dec 16 doi: 10.1016/j.annonc.2022.12.008. PMID: 36535565
Kojima T, Shah MA, Muro K, Francois E, Adenis A, Hsu CH, Doi T, Moriwaki T, Kim SB, Lee SH, Bennouna J, Kato K, Shen L, Enzinger P, Qin SK, Ferreira P, Chen J, Girotto G, de la Fouchardiere C, Senellart H, Al-Rajabi R, Lordick F, Wang R, Suryawanshi S, Bhagia P, Kang SP, Metges JP; KEYNOTE-181 Investigators
J Clin Oncol 2020 Dec 10;38(35):4138-4148. Epub 2020 Oct 7 doi: 10.1200/JCO.20.01888. PMID: 33026938
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML
N Engl J Med 2016 Nov 10;375(19):1856-1867. Epub 2016 Oct 8 doi: 10.1056/NEJMoa1602252. PMID: 27718784Free PMC Article
Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, Cheng JD, Chow LQ
Lancet Oncol 2016 Jul;17(7):956-965. Epub 2016 May 27 doi: 10.1016/S1470-2045(16)30066-3. PMID: 27247226

Clinical prediction guides

Haddad RI, Harrington K, Tahara M, Ferris RL, Gillison M, Fayette J, Daste A, Koralewski P, Zurawski B, Taberna M, Saba NF, Mak M, Kawecki A, Girotto G, Alvarez Avitia MA, Even C, Toledo JGR, Guminski A, Müller-Richter U, Kiyota N, Roberts M, Khan TA, Miller-Moslin K, Wei L, Argiris A
J Clin Oncol 2023 Apr 20;41(12):2166-2180. Epub 2022 Dec 6 doi: 10.1200/JCO.22.00332. PMID: 36473143Free PMC Article
Kojima T, Shah MA, Muro K, Francois E, Adenis A, Hsu CH, Doi T, Moriwaki T, Kim SB, Lee SH, Bennouna J, Kato K, Shen L, Enzinger P, Qin SK, Ferreira P, Chen J, Girotto G, de la Fouchardiere C, Senellart H, Al-Rajabi R, Lordick F, Wang R, Suryawanshi S, Bhagia P, Kang SP, Metges JP; KEYNOTE-181 Investigators
J Clin Oncol 2020 Dec 10;38(35):4138-4148. Epub 2020 Oct 7 doi: 10.1200/JCO.20.01888. PMID: 33026938
Burtness B, Harrington KJ, Greil R, Soulières D, Tahara M, de Castro G Jr, Psyrri A, Basté N, Neupane P, Bratland Å, Fuereder T, Hughes BGM, Mesía R, Ngamphaiboon N, Rordorf T, Wan Ishak WZ, Hong RL, González Mendoza R, Roy A, Zhang Y, Gumuscu B, Cheng JD, Jin F, Rischin D; KEYNOTE-048 Investigators
Lancet 2019 Nov 23;394(10212):1915-1928. Epub 2019 Nov 1 doi: 10.1016/S0140-6736(19)32591-7. PMID: 31679945
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington KJ, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Docampo LCI, Haddad R, Rordorf T, Kiyota N, Tahara M, Lynch M, Jayaprakash V, Li L, Gillison ML
Oral Oncol 2018 Jun;81:45-51. Epub 2018 Apr 17 doi: 10.1016/j.oraloncology.2018.04.008. PMID: 29884413Free PMC Article

Recent systematic reviews

Han X, Zhang H, Sun K, Li J, Wu W, Liu K, Yu Z
Front Immunol 2023;14:1302840. Epub 2024 Jan 17 doi: 10.3389/fimmu.2023.1302840. PMID: 38299153Free PMC Article
Yin G, Guo W, Duan H, Huang Z
Clin Otolaryngol 2021 Sep;46(5):1013-1020. Epub 2021 Apr 21 doi: 10.1111/coa.13772. PMID: 33765363
Winquist E, Al-Rasheedy I, Nichols AC, Palma DA, Stitt L
Cancer Treat Rev 2014 Oct;40(9):1073-9. Epub 2014 Aug 27 doi: 10.1016/j.ctrv.2014.08.002. PMID: 25200522
Lansbury L, Bath-Hextall F, Perkins W, Stanton W, Leonardi-Bee J
BMJ 2013 Nov 4;347:f6153. doi: 10.1136/bmj.f6153. PMID: 24191270Free PMC Article
Lansbury L, Leonardi-Bee J, Perkins W, Goodacre T, Tweed JA, Bath-Hextall FJ
Cochrane Database Syst Rev 2010 Apr 14;2010(4):CD007869. doi: 10.1002/14651858.CD007869.pub2. PMID: 20393962Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...