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Functioning Pituitary Neuroendocrine Tumor/Microadenoma

MedGen UID:
885844
•Concept ID:
C4054916
•
Neoplastic Process
Synonyms: Functioning PitNET/Microadenoma; Functioning Pituitary Gland Microadenoma

Definition

A pituitary neuroendocrine tumor/microadenoma associated with a hormonal syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFunctioning Pituitary Neuroendocrine Tumor/Microadenoma

Professional guidelines

PubMed

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients.
Burman P, Trouillas J, Losa M, McCormack A, Petersenn S, Popovic V, Theodoropoulou M, Raverot G, Dekkers OM; ESE survey collaborators †
Eur J Endocrinol 2022 Oct 1;187(4):593-605. Epub 2022 Sep 19 doi: 10.1530/EJE-22-0440. PMID: 36018781Free PMC Article
Update on the clinical management of multiple endocrine neoplasia type 1.
Pieterman CRC, Valk GD
Clin Endocrinol (Oxf) 2022 Oct;97(4):409-423. Epub 2022 Apr 1 doi: 10.1111/cen.14727. PMID: 35319130Free PMC Article

Recent clinical studies

Etiology

Natural history of non-functioning pituitary microadenomas: results from the UK non-functioning pituitary adenoma consortium.
Hamblin R, Fountas A, Lithgow K, Loughrey PB, Bonanos E, Shinwari SK, Mitchell K, Shah S, Grixti L, Matheou M, Isand K, McLaren DS, Surya A, Ullah HZ, Klaucane K, Jayasuriya A, Bhatti S, Mavilakandy A, Ahsan M, Mathew S, Hussein Z, Jansz T, Wunna W, MacFarlane J, Ayuk J, Abraham P, Drake WM, Gurnell M, Brooke A, Baldeweg SE, Sam AH, Martin N, Higham C, Reddy N, Levy MJ, Ahluwalia R, Newell-Price J, Vamvakopoulos J, Krishnan A, Lansdown A, Murray RD, Pal A, Bradley K, Mamoojee Y, Purewal T, Panicker J, Freel EM, Hasan F, Kumar M, Jose B, Hunter SJ, Karavitaki N
Eur J Endocrinol 2023 Jul 20;189(1):87-95. doi: 10.1093/ejendo/lvad070. PMID: 37345849
Update on the clinical management of multiple endocrine neoplasia type 1.
Pieterman CRC, Valk GD
Clin Endocrinol (Oxf) 2022 Oct;97(4):409-423. Epub 2022 Apr 1 doi: 10.1111/cen.14727. PMID: 35319130Free PMC Article
Pituitary Apoplexy: A Comprehensive Review.
Muthukumar N
Neurol India 2020 May-Jun;68(Supplement):S72-S78. doi: 10.4103/0028-3886.287669. PMID: 32611895
Prolactin Secreting Pituitary Microadenoma: Results of Transsphenoidal Surgery After Medical Therapy With Dopamine Agonist.
Fraioli MF, Umana G, Pagano A, Fraioli B, Lunardi P
J Craniofac Surg 2017 Jun;28(4):992-994. doi: 10.1097/SCS.0000000000003663. PMID: 28277481
Cushing's disease.
De Martin M, Pecori Giraldi F, Cavagnini F
Pituitary 2006;9(4):279-87. doi: 10.1007/s11102-006-0407-6. PMID: 17077950

Diagnosis

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Modern imaging in Cushing's disease.
Bashari WA, Gillett D, MacFarlane J, Powlson AS, Kolias AG, Mannion R, Scoffings DJ, Mendichovszky IA, Jones J, Cheow HK, Koulouri O, Gurnell M
Pituitary 2022 Oct;25(5):709-712. Epub 2022 Jun 6 doi: 10.1007/s11102-022-01236-w. PMID: 35666391Free PMC Article
Advances in the Imaging of Pituitary Tumors.
MacFarlane J, Bashari WA, Senanayake R, Gillett D, van der Meulen M, Powlson AS, Kolias A, Koulouri O, Gurnell M
Endocrinol Metab Clin North Am 2020 Sep;49(3):357-373. Epub 2020 Jul 15 doi: 10.1016/j.ecl.2020.06.002. PMID: 32741476
Acromegaly.
Ben-Shlomo A, Melmed S
Endocrinol Metab Clin North Am 2008 Mar;37(1):101-22, viii. doi: 10.1016/j.ecl.2007.10.002. PMID: 18226732Free PMC Article
Disorders of prolactin secretion.
Molitch ME
Endocrinol Metab Clin North Am 2001 Sep;30(3):585-610. doi: 10.1016/s0889-8529(05)70203-6. PMID: 11571932

Therapy

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients.
Burman P, Trouillas J, Losa M, McCormack A, Petersenn S, Popovic V, Theodoropoulou M, Raverot G, Dekkers OM; ESE survey collaborators †
Eur J Endocrinol 2022 Oct 1;187(4):593-605. Epub 2022 Sep 19 doi: 10.1530/EJE-22-0440. PMID: 36018781Free PMC Article
Acromegaly.
Ben-Shlomo A, Melmed S
Endocrinol Metab Clin North Am 2008 Mar;37(1):101-22, viii. doi: 10.1016/j.ecl.2007.10.002. PMID: 18226732Free PMC Article
Cushing's syndrome.
Howlett TA, Rees LH, Besser GM
Clin Endocrinol Metab 1985 Nov;14(4):911-45. doi: 10.1016/s0300-595x(85)80083-9. PMID: 3002679
Hyperprolactinemia.
Kemmann E, Jones JR
Am Fam Physician 1981 Mar;23(3):119-24. PMID: 7468401

Prognosis

Natural history of non-functioning pituitary microadenomas: results from the UK non-functioning pituitary adenoma consortium.
Hamblin R, Fountas A, Lithgow K, Loughrey PB, Bonanos E, Shinwari SK, Mitchell K, Shah S, Grixti L, Matheou M, Isand K, McLaren DS, Surya A, Ullah HZ, Klaucane K, Jayasuriya A, Bhatti S, Mavilakandy A, Ahsan M, Mathew S, Hussein Z, Jansz T, Wunna W, MacFarlane J, Ayuk J, Abraham P, Drake WM, Gurnell M, Brooke A, Baldeweg SE, Sam AH, Martin N, Higham C, Reddy N, Levy MJ, Ahluwalia R, Newell-Price J, Vamvakopoulos J, Krishnan A, Lansdown A, Murray RD, Pal A, Bradley K, Mamoojee Y, Purewal T, Panicker J, Freel EM, Hasan F, Kumar M, Jose B, Hunter SJ, Karavitaki N
Eur J Endocrinol 2023 Jul 20;189(1):87-95. doi: 10.1093/ejendo/lvad070. PMID: 37345849
Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients.
Burman P, Trouillas J, Losa M, McCormack A, Petersenn S, Popovic V, Theodoropoulou M, Raverot G, Dekkers OM; ESE survey collaborators †
Eur J Endocrinol 2022 Oct 1;187(4):593-605. Epub 2022 Sep 19 doi: 10.1530/EJE-22-0440. PMID: 36018781Free PMC Article
Update on the clinical management of multiple endocrine neoplasia type 1.
Pieterman CRC, Valk GD
Clin Endocrinol (Oxf) 2022 Oct;97(4):409-423. Epub 2022 Apr 1 doi: 10.1111/cen.14727. PMID: 35319130Free PMC Article
Cushing's disease.
De Martin M, Pecori Giraldi F, Cavagnini F
Pituitary 2006;9(4):279-87. doi: 10.1007/s11102-006-0407-6. PMID: 17077950
Cushing's syndrome.
Howlett TA, Rees LH, Besser GM
Clin Endocrinol Metab 1985 Nov;14(4):911-45. doi: 10.1016/s0300-595x(85)80083-9. PMID: 3002679

Clinical prediction guides

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients.
Burman P, Trouillas J, Losa M, McCormack A, Petersenn S, Popovic V, Theodoropoulou M, Raverot G, Dekkers OM; ESE survey collaborators †
Eur J Endocrinol 2022 Oct 1;187(4):593-605. Epub 2022 Sep 19 doi: 10.1530/EJE-22-0440. PMID: 36018781Free PMC Article
Update on the clinical management of multiple endocrine neoplasia type 1.
Pieterman CRC, Valk GD
Clin Endocrinol (Oxf) 2022 Oct;97(4):409-423. Epub 2022 Apr 1 doi: 10.1111/cen.14727. PMID: 35319130Free PMC Article
Prolactin Secreting Pituitary Microadenoma: Results of Transsphenoidal Surgery After Medical Therapy With Dopamine Agonist.
Fraioli MF, Umana G, Pagano A, Fraioli B, Lunardi P
J Craniofac Surg 2017 Jun;28(4):992-994. doi: 10.1097/SCS.0000000000003663. PMID: 28277481
Clinical review 65. Evaluation and treatment of the patient with a pituitary incidentaloma.
Molitch ME
J Clin Endocrinol Metab 1995 Jan;80(1):3-6. doi: 10.1210/jcem.80.1.7829630. PMID: 7829630

Recent systematic reviews

Natural History of Non-Functioning Pituitary Adenomas: A Systematic Review and Meta-Analysis.
Rikvold SD, Pedersen MB, Andreassen M, Krogh J
Horm Metab Res 2023 Jul;55(7):443-451. Epub 2023 Jul 10 doi: 10.1055/a-2096-1340. PMID: 37494058
Fluorescence-guided detection of pituitary neuroendocrine tumor (PitNET) tissue during endoscopic transsphenoidal surgery available agents, their potential, and technical aspects.
Vergeer RA, Theunissen REP, van Elk T, Schmidt I, Postma MR, Tamasi K, van Dijk JMC, Kuijlen JMA
Rev Endocr Metab Disord 2022 Jun;23(3):647-657. Epub 2022 Mar 28 doi: 10.1007/s11154-022-09718-9. PMID: 35344185Free PMC Article
Thyrotropin-secreting pituitary adenomas: a systematic review and meta-analysis of postoperative outcomes and management.
Cossu G, Daniel RT, Pierzchala K, Berhouma M, Pitteloud N, Lamine F, Colao A, Messerer M
Pituitary 2019 Feb;22(1):79-88. doi: 10.1007/s11102-018-0921-3. PMID: 30390277
Plurihormonal ACTH-GH Pituitary Adenoma: Case Report and Systematic Literature Review.
Roca E, Mattogno PP, Porcelli T, Poliani L, Belotti F, Schreiber A, Maffezzoni F, Fontanella MM, Doglietto F
World Neurosurg 2018 Jun;114:e158-e164. Epub 2018 Mar 6 doi: 10.1016/j.wneu.2018.02.120. PMID: 29501516
Metabolic In Vivo Visualization of Pituitary Adenomas: a Systematic Review of Imaging Modalities.
Yao A, Balchandani P, Shrivastava RK
World Neurosurg 2017 Aug;104:489-498. Epub 2017 Apr 28 doi: 10.1016/j.wneu.2017.04.128. PMID: 28461279Free PMC Article

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