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Functioning pituitary gland neoplasm

MedGen UID:
163414
•Concept ID:
C0851693
•
Neoplastic Process
Synonyms: functioning endocrine neoplasm of pituitary gland; functioning pituitary gland neoplasm; functioning pituitary neoplasm; functioning pituitary tumor; functioning pituitary tumour; growth hormone producing pituitary tumour; hormone producing pituitary cancer; hormone producing pituitary neoplasm; pituitary gland functioning endocrine neoplasm; pituitary neoplasms, hormone producing; pituitary tumors, hormone producing; secretory pituitary tumor; secretory pituitary tumour; somatotropinoma
 
Monarch Initiative: MONDO:0003604

Definition

A hormone producing pituitary gland tumor, associated with a hormonal syndrome. [from MONDO]

Professional guidelines

PubMed

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
A Pituitary Society update to acromegaly management guidelines.
Fleseriu M, Biller BMK, Freda PU, Gadelha MR, Giustina A, Katznelson L, Molitch ME, Samson SL, Strasburger CJ, van der Lely AJ, Melmed S
Pituitary 2021 Feb;24(1):1-13. Epub 2020 Oct 20 doi: 10.1007/s11102-020-01091-7. PMID: 33079318Free PMC Article

Recent clinical studies

Etiology

Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline.
Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO, Tabarin A; Endocrine Society
J Clin Endocrinol Metab 2015 Aug;100(8):2807-31. Epub 2015 Jul 29 doi: 10.1210/jc.2015-1818. PMID: 26222757Free PMC Article
Management of clinically non-functioning pituitary adenoma.
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284
Pituitary incidentaloma: an endocrine society clinical practice guideline.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, Vance ML; Endocrine Society
J Clin Endocrinol Metab 2011 Apr;96(4):894-904. doi: 10.1210/jc.2010-1048. PMID: 21474686Free PMC Article
Craniopharyngioma surgery.
Honegger J, Tatagiba M
Pituitary 2008;11(4):361-73. doi: 10.1007/s11102-008-0137-z. PMID: 18636330

Diagnosis

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Prolactinomas.
Huynh PP, Ishii LE, Ishii M
JAMA 2021 Jan 12;325(2):195. doi: 10.1001/jama.2020.3744. PMID: 33433577
Management of clinically non-functioning pituitary adenoma.
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284
Silent pituitary adenomas.
Mayson SE, Snyder PJ
Endocrinol Metab Clin North Am 2015 Mar;44(1):79-87. Epub 2014 Nov 6 doi: 10.1016/j.ecl.2014.11.001. PMID: 25732644
Pituitary adenomas: an overview.
Lake MG, Krook LS, Cruz SV
Am Fam Physician 2013 Sep 1;88(5):319-27. PMID: 24010395

Therapy

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Management of Hypothalamic Obesity.
Müller HL
Endocrinol Metab Clin North Am 2020 Sep;49(3):533-552. Epub 2020 Jul 15 doi: 10.1016/j.ecl.2020.05.009. PMID: 32741487
Diagnosis and management of craniopharyngiomas in the era of genomics and targeted therapy.
Martinez-Gutierrez JC, D'Andrea MR, Cahill DP, Santagata S, Barker FG 2nd, Brastianos PK
Neurosurg Focus 2016 Dec;41(6):E2. doi: 10.3171/2016.9.FOCUS16325. PMID: 27903124
Antipsychotic-induced hyperprolactinemia.
Bostwick JR, Guthrie SK, Ellingrod VL
Pharmacotherapy 2009 Jan;29(1):64-73. doi: 10.1592/phco.29.1.64. PMID: 19113797
Craniopharyngioma in childhood.
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867

Prognosis

The epidemiology, diagnosis and treatment of Prolactinomas: The old and the new.
Chanson P, Maiter D
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101290. Epub 2019 Jul 10 doi: 10.1016/j.beem.2019.101290. PMID: 31326373
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Pituitary incidentaloma: an endocrine society clinical practice guideline.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, Vance ML; Endocrine Society
J Clin Endocrinol Metab 2011 Apr;96(4):894-904. doi: 10.1210/jc.2010-1048. PMID: 21474686Free PMC Article
The craniopharyngioma.
Oskouian RJ, Samii A, Laws ERJ Jr
Front Horm Res 2006;34:105-126. doi: 10.1159/000091578. PMID: 16474218
Incidental pituitary macroadenomas.
Chacko AG, Chandy MJ
Br J Neurosurg 1992;6(3):233-6. doi: 10.3109/02688699209002931. PMID: 1632922

Clinical prediction guides

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Pituitary adenomas: an overview.
Lake MG, Krook LS, Cruz SV
Am Fam Physician 2013 Sep 1;88(5):319-27. PMID: 24010395
Pituitary incidentaloma.
Bevan JS
Clin Med (Lond) 2013 Jun;13(3):296-8. doi: 10.7861/clinmedicine.13-3-296. PMID: 23760707Free PMC Article

Recent systematic reviews

Prolactin in headache and migraine: A systematic review of clinical studies.
Al-Karagholi MA, Kalatharan V, Ghanizada H, Gram C, Dussor G, Ashina M
Cephalalgia 2023 Feb;43(2):3331024221136286. doi: 10.1177/03331024221136286. PMID: 36718026
The metabolic role of prolactin: systematic review, meta-analysis and preclinical considerations.
Corona G, Rastrelli G, Comeglio P, Guaraldi F, Mazzatenta D, Sforza A, Vignozzi L, Maggi M
Expert Rev Endocrinol Metab 2022 Nov;17(6):533-545. Epub 2022 Nov 29 doi: 10.1080/17446651.2022.2144829. PMID: 36447418
Treatment of non-functioning pituitary adenoma with cabergoline: a systematic review and meta-analysis.
Botelho MS, Franzini ÍA, Nunes-Nogueira VDS, Boguszewski CL
Pituitary 2022 Dec;25(6):810-818. Epub 2022 Jul 28 doi: 10.1007/s11102-022-01257-5. PMID: 35902444
Immune-checkpoint inhibitors in pituitary malignancies.
Di Nunno V, Franceschi E, Tosoni A, Gatto L, Maggio I, Lodi R, Bartolini S, Brandes AA
Anticancer Drugs 2022 Jan 1;33(1):e28-e35. doi: 10.1097/CAD.0000000000001157. PMID: 34348358
Osteoporotic fractures in patients with untreated hyperprolactinemia vs. those taking dopamine agonists: A systematic review and meta-analysis.
D'Sylva C, Khan T, Van Uum S, Fraser LA
Neuro Endocrinol Lett 2015;36(8):745-9. PMID: 26921574

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