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Endemic Burkitt Lymphoma

MedGen UID:
87474
•Concept ID:
C0343640
•
Neoplastic Process
Synonyms: African Lymphoma; Lymphoma, African
SNOMED CT: Endemic Burkitt's lymphoma (419770008); Endemic Burkitt lymphoma (419770008); African Burkitt lymphoma (240531002); African Burkitt's lymphoma (240531002)

Definition

A clinical variant of Burkitt lymphoma that occurs in equatorial Africa. The Epstein-Barr virus has been detected in all patients. It is the most common malignancy of childhood in this area. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndemic Burkitt Lymphoma

Professional guidelines

PubMed

The use of anthracyclines in the treatment of endemic Burkitt lymphoma.
Molyneux E, Schwalbe E, Chagaluka G, Banda K, Israels T, Depani S, Mittermayer-Vassallo K, Windebank K, Mvula J, Njiram'madzi J, O'Brien S, Carey P, Bailey S
Br J Haematol 2017 Jun;177(6):984-990. Epub 2016 Nov 28 doi: 10.1111/bjh.14440. PMID: 27891583
Practical recommendations for the management of children with endemic Burkitt lymphoma (BL) in a resource limited setting.
Hesseling P, Israels T, Harif M, Chantada G, Molyneux E; Pediatric Oncology in Developing Countries
Pediatr Blood Cancer 2013 Mar;60(3):357-62. Epub 2012 Nov 28 doi: 10.1002/pbc.24407. PMID: 23192950
Intussusception as a presenting feature of Burkitt lymphoma: implications for management and outcome.
England RJ, Pillay K, Davidson A, Numanoglu A, Millar AJ
Pediatr Surg Int 2012 Mar;28(3):267-70. Epub 2011 Oct 4 doi: 10.1007/s00383-011-2982-5. PMID: 21969235

Recent clinical studies

Etiology

Childhood cancer: Estimating regional and global incidence.
Johnston WT, Erdmann F, Newton R, Steliarova-Foucher E, Schüz J, Roman E
Cancer Epidemiol 2021 Apr;71(Pt B):101662. Epub 2020 Jan 8 doi: 10.1016/j.canep.2019.101662. PMID: 31924557
HIV-associated Burkitt lymphoma.
Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838
Kaposi Sarcoma-Associated Herpesvirus Infection and Endemic Burkitt Lymphoma.
Oluoch PO, Oduor CI, Forconi CS, Ong'echa JM, Münz C, Dittmer DP, Bailey JA, Moormann AM
J Infect Dis 2020 Jun 16;222(1):111-120. doi: 10.1093/infdis/jiaa060. PMID: 32072172Free PMC Article
The promise of a prophylactic Epstein-Barr virus vaccine.
Balfour HH Jr, Schmeling DO, Grimm-Geris JM
Pediatr Res 2020 Jan;87(2):345-352. Epub 2019 Oct 3 doi: 10.1038/s41390-019-0591-5. PMID: 31641280Free PMC Article
An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma.
Murray PG, Young LS
Blood 2019 Aug 15;134(7):591-596. Epub 2019 Jun 11 doi: 10.1182/blood.2019000568. PMID: 31186275

Diagnosis

Malaria Infection and Risk for Endemic Burkitt Lymphoma: A Systematic Review and Meta-Analysis.
Kotepui KU, Kotepui M
Int J Environ Res Public Health 2021 May 30;18(11) doi: 10.3390/ijerph18115886. PMID: 34070881Free PMC Article
Epstein-Barr virus microRNAs in the pathogenesis of human cancers.
Caetano BFR, Jorge BAS, Müller-Coan BG, Elgui de Oliveira D
Cancer Lett 2021 Feb 28;499:14-23. Epub 2020 Nov 25 doi: 10.1016/j.canlet.2020.11.019. PMID: 33248209
Childhood cancer: Estimating regional and global incidence.
Johnston WT, Erdmann F, Newton R, Steliarova-Foucher E, Schüz J, Roman E
Cancer Epidemiol 2021 Apr;71(Pt B):101662. Epub 2020 Jan 8 doi: 10.1016/j.canep.2019.101662. PMID: 31924557
Epidemiology of adult and pediatric Burkitt lymphoma in Canada: sequelae of the HIV epidemic.
Roy SF, Ghazawi FM, Le M, Lagacé F, Roy CF, Rahme E, Savin E, Zubarev A, Sasseville D, Popradi G, Litvinov IV
Curr Oncol 2020 Apr;27(2):83-89. Epub 2020 May 1 doi: 10.3747/co.27.5775. PMID: 32489250Free PMC Article
Parasite Infection, Carcinogenesis and Human Malignancy.
van Tong H, Brindley PJ, Meyer CG, Velavan TP
EBioMedicine 2017 Feb;15:12-23. Epub 2016 Dec 2 doi: 10.1016/j.ebiom.2016.11.034. PMID: 27956028Free PMC Article

Therapy

Malaria Infection and Risk for Endemic Burkitt Lymphoma: A Systematic Review and Meta-Analysis.
Kotepui KU, Kotepui M
Int J Environ Res Public Health 2021 May 30;18(11) doi: 10.3390/ijerph18115886. PMID: 34070881Free PMC Article
The promise of a prophylactic Epstein-Barr virus vaccine.
Balfour HH Jr, Schmeling DO, Grimm-Geris JM
Pediatr Res 2020 Jan;87(2):345-352. Epub 2019 Oct 3 doi: 10.1038/s41390-019-0591-5. PMID: 31641280Free PMC Article
Survival of children with endemic Burkitt lymphoma in a prospective clinical care project in Uganda.
McGoldrick SM, Mutyaba I, Adams SV, Larsen A, Krantz EM, Namirembe C, Mooka P, Nabakooza S, Ndagire M, Mubiru K, Nabwana M, Nankinga R, Gerdts S, Gordon-Maclean C, Geriga F, Omoding A, Sessle E, Kambugu J, Uldrick TS, Orem J, Casper C
Pediatr Blood Cancer 2019 Sep;66(9):e27813. Epub 2019 Jun 3 doi: 10.1002/pbc.27813. PMID: 31157502
Therapeutic Strategies against Epstein-Barr Virus-Associated Cancers Using Proteasome Inhibitors.
Hui KF, Tam KP, Chiang AKS
Viruses 2017 Nov 21;9(11) doi: 10.3390/v9110352. PMID: 29160853Free PMC Article
The use of anthracyclines in the treatment of endemic Burkitt lymphoma.
Molyneux E, Schwalbe E, Chagaluka G, Banda K, Israels T, Depani S, Mittermayer-Vassallo K, Windebank K, Mvula J, Njiram'madzi J, O'Brien S, Carey P, Bailey S
Br J Haematol 2017 Jun;177(6):984-990. Epub 2016 Nov 28 doi: 10.1111/bjh.14440. PMID: 27891583

Prognosis

Childhood cancer: Estimating regional and global incidence.
Johnston WT, Erdmann F, Newton R, Steliarova-Foucher E, Schüz J, Roman E
Cancer Epidemiol 2021 Apr;71(Pt B):101662. Epub 2020 Jan 8 doi: 10.1016/j.canep.2019.101662. PMID: 31924557
HIV-associated Burkitt lymphoma.
Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838
Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences.
Kaymaz Y, Oduor CI, Yu H, Otieno JA, Ong'echa JM, Moormann AM, Bailey JA
Mol Cancer Res 2017 May;15(5):563-576. doi: 10.1158/1541-7786.MCR-16-0305. PMID: 28465297Free PMC Article
Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human.
Eason AB, Sin SH, Lin C, Damania B, Park S, Fedoriw Y, Bacchi CE, Dittmer DP
Oncotarget 2016 Sep 27;7(39):63504-63513. doi: 10.18632/oncotarget.11531. PMID: 27566574Free PMC Article
Endemic Burkitt Lymphoma: Long-term Outcome in 87 Patients Who Presented With Paraplegia in Cameroon.
Hesseling PB, Mbah G, Kouya F, Kimbi C, Nfor P, Kaah J, Kuruvilla R, Best A, Wharin P
Pediatr Hematol Oncol 2015;32(8):525-8. Epub 2015 Nov 25 doi: 10.3109/08880018.2015.1085936. PMID: 26606160

Clinical prediction guides

Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children.
Muriuki BM, Forconi CS, Oluoch PO, Bailey JA, Ghansah A, Moormann AM, Ong'echa JM
Sci Rep 2021 May 31;11(1):11343. doi: 10.1038/s41598-021-90596-7. PMID: 34059753Free PMC Article
Epidemiology of adult and pediatric Burkitt lymphoma in Canada: sequelae of the HIV epidemic.
Roy SF, Ghazawi FM, Le M, Lagacé F, Roy CF, Rahme E, Savin E, Zubarev A, Sasseville D, Popradi G, Litvinov IV
Curr Oncol 2020 Apr;27(2):83-89. Epub 2020 May 1 doi: 10.3747/co.27.5775. PMID: 32489250Free PMC Article
Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences.
Kaymaz Y, Oduor CI, Yu H, Otieno JA, Ong'echa JM, Moormann AM, Bailey JA
Mol Cancer Res 2017 May;15(5):563-576. doi: 10.1158/1541-7786.MCR-16-0305. PMID: 28465297Free PMC Article
Parasite Infection, Carcinogenesis and Human Malignancy.
van Tong H, Brindley PJ, Meyer CG, Velavan TP
EBioMedicine 2017 Feb;15:12-23. Epub 2016 Dec 2 doi: 10.1016/j.ebiom.2016.11.034. PMID: 27956028Free PMC Article
Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma.
Abate F, Ambrosio MR, Mundo L, Laginestra MA, Fuligni F, Rossi M, Zairis S, Gazaneo S, De Falco G, Lazzi S, Bellan C, Rocca BJ, Amato T, Marasco E, Etebari M, Ogwang M, Calbi V, Ndede I, Patel K, Chumba D, Piccaluga PP, Pileri S, Leoncini L, Rabadan R
PLoS Pathog 2015 Oct;11(10):e1005158. Epub 2015 Oct 15 doi: 10.1371/journal.ppat.1005158. PMID: 26468873Free PMC Article

Recent systematic reviews

Malaria Infection and Risk for Endemic Burkitt Lymphoma: A Systematic Review and Meta-Analysis.
Kotepui KU, Kotepui M
Int J Environ Res Public Health 2021 May 30;18(11) doi: 10.3390/ijerph18115886. PMID: 34070881Free PMC Article
Reproductive organ involvement in non-Hodgkin lymphoma during pregnancy: a systematic review.
Horowitz NA, Benyamini N, Wohlfart K, Brenner B, Avivi I
Lancet Oncol 2013 Jun;14(7):e275-82. doi: 10.1016/S1470-2045(12)70589-2. PMID: 23725710

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