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Abnormal sacrum morphology

MedGen UID:
870793
•Concept ID:
C4025250
•
Anatomical Abnormality
Synonym: Abnormality of the sacrum
 
HPO: HP:0005107

Definition

An abnormality of the sacral bone. [from HPO]

Professional guidelines

PubMed

Novel MNX1 mutations and genotype-phenotype analysis of patients with Currarino syndrome.
Han L, Zhang Z, Wang H, Song H, Gao Q, Yan Y, Tao R, Xiao P, Li L, Jiang Q, Li Q
Orphanet J Rare Dis 2020 Jun 22;15(1):155. doi: 10.1186/s13023-020-01442-4. PMID: 32571425Free PMC Article
Diagnostic criteria for camptocormia in Parkinson's disease: A consensus-based proposal.
Fasano A, Geroin C, Berardelli A, Bloem BR, Espay AJ, Hallett M, Lang AE, Tinazzi M
Parkinsonism Relat Disord 2018 Aug;53:53-57. Epub 2018 May 8 doi: 10.1016/j.parkreldis.2018.04.033. PMID: 29759930Free PMC Article
Sacral agenesis: a clinical evaluation of its management, heredity, and associated anomalies.
Andrish J, Kalamchi A, MacEwen GD
Clin Orthop Relat Res 1979 Mar-Apr;(139):52-7. PMID: 455850

Recent clinical studies

Etiology

Relationship between spinal morphology and function and adolescent non-specific back pain: A cross-sectional study.
Feng Q, Jiang C, Zhou Y, Huang Y, Zhang M
J Back Musculoskelet Rehabil 2017;30(3):625-633. doi: 10.3233/BMR-160544. PMID: 28234252
Congenital lumbosacral lipomas.
Pierre-Kahn A, Zerah M, Renier D, Cinalli G, Sainte-Rose C, Lellouch-Tubiana A, Brunelle F, Le Merrer M, Giudicelli Y, Pichon J, Kleinknecht B, Nataf F
Childs Nerv Syst 1997 Jun;13(6):298-334; discussion 335. doi: 10.1007/s003810050090. PMID: 9272285
Anorectal malformations.
Peña A
Semin Pediatr Surg 1995 Feb;4(1):35-47. PMID: 7728507
Fetal sacrococcygeal teratoma.
Flake AW
Semin Pediatr Surg 1993 May;2(2):113-20. PMID: 8062028
Congenital sacral anomalies.
Stanley JK, Owen R, Koff S
J Bone Joint Surg Br 1979 Nov;61-B(4):401-9. doi: 10.1302/0301-620X.61B4.500747. PMID: 500747

Diagnosis

Currarino triad.
Baalaan KP, Gurunathan N
Pan Afr Med J 2022;41:143. Epub 2022 Feb 17 doi: 10.11604/pamj.2022.41.143.33419. PMID: 35519164Free PMC Article
Currarino syndrome: a comprehensive genetic review of a rare congenital disorder.
Dworschak GC, Reutter HM, Ludwig M
Orphanet J Rare Dis 2021 Apr 9;16(1):167. doi: 10.1186/s13023-021-01799-0. PMID: 33836786Free PMC Article
Anorectal malformations.
Levitt MA, Peña A
Orphanet J Rare Dis 2007 Jul 26;2:33. doi: 10.1186/1750-1172-2-33. PMID: 17651510Free PMC Article
Magnetic resonance imaging of the lumbar spine in people without back pain.
Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS
N Engl J Med 1994 Jul 14;331(2):69-73. doi: 10.1056/NEJM199407143310201. PMID: 8208267
Fetal sacrococcygeal teratoma.
Flake AW
Semin Pediatr Surg 1993 May;2(2):113-20. PMID: 8062028

Therapy

Congenital musculoskeletal anomalies - key radiographic findings.
Gill KG
Pediatr Radiol 2022 Apr;52(4):777-785. Epub 2021 Nov 3 doi: 10.1007/s00247-021-05200-x. PMID: 34731287
Postoperative "complications" following laparoscopic-assisted anorectoplasty: A systematic review.
Pathak M, Saxena AK
Pediatr Surg Int 2020 Nov;36(11):1299-1307. Epub 2020 Sep 26 doi: 10.1007/s00383-020-04748-3. PMID: 32980932
Sacral spinous processes: a morphologic classification and biomechanical characterization of strength.
Wang T, Fielding LC, Parikh A, Kothari M, Alamin T
Spine J 2015 Dec 1;15(12):2544-51. Epub 2015 Sep 4 doi: 10.1016/j.spinee.2015.08.058. PMID: 26343242
Magnetic resonance imaging of the lumbar spine in people without back pain.
Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS
N Engl J Med 1994 Jul 14;331(2):69-73. doi: 10.1056/NEJM199407143310201. PMID: 8208267
Anterior sacral meningocele.
Ivamoto HS, Wallman LJ
Arch Neurol 1974 Nov;31(5):345-6. doi: 10.1001/archneur.1974.00490410093011. PMID: 4412041

Prognosis

Relationship between spinal morphology and function and adolescent non-specific back pain: A cross-sectional study.
Feng Q, Jiang C, Zhou Y, Huang Y, Zhang M
J Back Musculoskelet Rehabil 2017;30(3):625-633. doi: 10.3233/BMR-160544. PMID: 28234252
Anorectal malformations.
Levitt MA, Peña A
Orphanet J Rare Dis 2007 Jul 26;2:33. doi: 10.1186/1750-1172-2-33. PMID: 17651510Free PMC Article
Congenital lumbosacral lipomas.
Pierre-Kahn A, Zerah M, Renier D, Cinalli G, Sainte-Rose C, Lellouch-Tubiana A, Brunelle F, Le Merrer M, Giudicelli Y, Pichon J, Kleinknecht B, Nataf F
Childs Nerv Syst 1997 Jun;13(6):298-334; discussion 335. doi: 10.1007/s003810050090. PMID: 9272285
Anorectal malformations.
Peña A
Semin Pediatr Surg 1995 Feb;4(1):35-47. PMID: 7728507
Fetal sacrococcygeal teratoma.
Flake AW
Semin Pediatr Surg 1993 May;2(2):113-20. PMID: 8062028

Clinical prediction guides

Currarino syndrome: a comprehensive genetic review of a rare congenital disorder.
Dworschak GC, Reutter HM, Ludwig M
Orphanet J Rare Dis 2021 Apr 9;16(1):167. doi: 10.1186/s13023-021-01799-0. PMID: 33836786Free PMC Article
Anorectal malformations associated spinal cord anomalies.
Totonelli G, Morini F, Catania VD, Schingo PM, Mosiello G, Palma P, Iacobelli BD, Bagolan P
Pediatr Surg Int 2016 Aug;32(8):729-35. Epub 2016 Jul 2 doi: 10.1007/s00383-016-3914-1. PMID: 27372296
Spondylolisthesis, Sacro-Pelvic Morphology, and Orientation in Young Gymnasts.
Toueg CW, Mac-Thiong JM, Grimard G, Poitras B, Parent S, Labelle H
J Spinal Disord Tech 2015 Jul;28(6):E358-64. doi: 10.1097/BSD.0b013e3182956d62. PMID: 24201157
Anorectal malformations.
Levitt MA, Peña A
Orphanet J Rare Dis 2007 Jul 26;2:33. doi: 10.1186/1750-1172-2-33. PMID: 17651510Free PMC Article
A case in the spectrum of the oculo-encephalo-hepato-renal syndrome.
Ehara H, Tamaoki Y, Eda I
Pediatr Neurol 1999 Oct;21(4):757-62. doi: 10.1016/s0887-8994(99)00078-8. PMID: 10580893

Recent systematic reviews

Lumbo-sacral pedicular aplasia diagnosis and treatment: a systematic literature review and case report.
Galieri G, Mazzucchi E, Pignotti F, Rinaldi P, De Santis V, La Rocca G, Sabatino G
Br J Neurosurg 2024 Dec;38(6):1269-1275. Epub 2022 Apr 8 doi: 10.1080/02688697.2022.2057431. PMID: 35393903
Postoperative "complications" following laparoscopic-assisted anorectoplasty: A systematic review.
Pathak M, Saxena AK
Pediatr Surg Int 2020 Nov;36(11):1299-1307. Epub 2020 Sep 26 doi: 10.1007/s00383-020-04748-3. PMID: 32980932
Anatomy and clinical significance of sacral variations: a systematic review.
Nastoulis E, Karakasi MV, Pavlidis P, Thomaidis V, Fiska A
Folia Morphol (Warsz) 2019;78(4):651-667. Epub 2019 Apr 5 doi: 10.5603/FM.a2019.0040. PMID: 30949993
Presentation and outcomes of patients with thoracic and lumbosacral spinal epidural arteriovenous fistulas: a systematic review and meta-analysis.
Byun JS, Tsang ACO, Hilditch CA, Nicholson P, Fang YB, Krings T, Pereira VM, Lanzino G, Brinjikji W
J Neurointerv Surg 2019 Jan;11(1):95-98. Epub 2018 Aug 30 doi: 10.1136/neurintsurg-2018-014203. PMID: 30166334
Long-term follow-up of functional outcome in patients with a cloacal malformation: a systematic review.
Versteegh HP, van Rooij IA, Levitt MA, Sloots CE, Wijnen RM, de Blaauw I
J Pediatr Surg 2013 Nov;48(11):2343-50. doi: 10.1016/j.jpedsurg.2013.08.027. PMID: 24210210

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