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Delayed ossification of the sacrum

MedGen UID:
1371093
•Concept ID:
C4476737
•
Finding
HPO: HP:0025371

Definition

Formation of the sacrum bone tissue occurs later than age-adjusted norms. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDelayed ossification of the sacrum

Recent clinical studies

Etiology

New osseous soft markers for trisomy 13, 18 and 21.
Achter A, Hager T, Fimmers R, Gembruch U, Müller AM
Arch Gynecol Obstet 2016 Aug;294(2):251-9. Epub 2015 Nov 30 doi: 10.1007/s00404-015-3971-z. PMID: 26620204
Implant design may influence delayed heterotopic ossification after total disk arthroplasty in lumbar spine.
Kerr EJ, Jawahar A, Kay S, Cavanaugh DA, Nunley PD
Surg Neurol 2009 Dec;72(6):747-51; discussion 751. doi: 10.1016/j.surneu.2009.04.009. PMID: 20082839
The incidence of ossification of the sacrococcygeal joint.
Saluja PG
J Anat 1988 Feb;156:11-5. PMID: 3138225Free PMC Article

Diagnosis

New osseous soft markers for trisomy 13, 18 and 21.
Achter A, Hager T, Fimmers R, Gembruch U, Müller AM
Arch Gynecol Obstet 2016 Aug;294(2):251-9. Epub 2015 Nov 30 doi: 10.1007/s00404-015-3971-z. PMID: 26620204
A second family with autosomal recessive spondylometaphyseal dysplasia and early death.
Mégarbané A, Mehawej C, El Zahr A, Haddad S, Cormier-Daire V
Am J Med Genet A 2014 Apr;164A(4):1010-4. Epub 2014 Jan 23 doi: 10.1002/ajmg.a.36372. PMID: 24458487
Implant design may influence delayed heterotopic ossification after total disk arthroplasty in lumbar spine.
Kerr EJ, Jawahar A, Kay S, Cavanaugh DA, Nunley PD
Surg Neurol 2009 Dec;72(6):747-51; discussion 751. doi: 10.1016/j.surneu.2009.04.009. PMID: 20082839

Therapy

Delayed, Reversible Cervical Paralysis After Scoliosis Corrective Surgery in a Child with Osteogenesis Imperfecta: A Case Report.
Goh BC, Jain A, Sponseller PD
JBJS Case Connect 2018 Jan-Mar;8(1):e16. doi: 10.2106/JBJS.CC.17.00185. PMID: 29538094
Implant design may influence delayed heterotopic ossification after total disk arthroplasty in lumbar spine.
Kerr EJ, Jawahar A, Kay S, Cavanaugh DA, Nunley PD
Surg Neurol 2009 Dec;72(6):747-51; discussion 751. doi: 10.1016/j.surneu.2009.04.009. PMID: 20082839

Prognosis

Implant design may influence delayed heterotopic ossification after total disk arthroplasty in lumbar spine.
Kerr EJ, Jawahar A, Kay S, Cavanaugh DA, Nunley PD
Surg Neurol 2009 Dec;72(6):747-51; discussion 751. doi: 10.1016/j.surneu.2009.04.009. PMID: 20082839
Diaphanospondylodysostosis (DSD): confirmation of a recessive disorder with abnormal vertebral ossification and nephroblastomatosis.
Gonzales M, Verloes A, Saint Frison MH, Perrotez C, Bourdet O, Encha-Razavi F, Joyé N, Taillemite JL, Walbaum R, Pfeiffer R, Maroteaux P
Am J Med Genet A 2005 Aug 1;136A(4):373-6. doi: 10.1002/ajmg.a.30537. PMID: 15988748

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