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Intolerance to infant formula

MedGen UID:
837723
•Concept ID:
C3267180
•
Disease or Syndrome
Synonyms: Breast Milk Substitute Intolerance; Infant Formula Intolerance; Infant formula intolerance
SNOMED CT: Infant formula intolerance (81781000119107); Intolerance to infant formula (81781000119107)

Definition

Inability to effectively digest or absorb the components of breast milk substitutes. Symptoms may include emesis, abdominal distension or diarrhea. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntolerance to infant formula

Professional guidelines

PubMed

Consensus statement on diagnosis, treatment and follow-up of cow's milk protein allergy among infants and children in Turkey.
Kansu A, Yüce A, Dalgıç B, Şekerel BE, Çullu-Çokuğraş F, Çokuğraş H
Turk J Pediatr 2016;58(1):1-11. doi: 10.24953/turkjped.2016.01.001. PMID: 27922230
Infantile Colic: Recognition and Treatment.
Johnson JD, Cocker K, Chang E
Am Fam Physician 2015 Oct 1;92(7):577-82. PMID: 26447441
Is there a consensus in food allergy management?
Lifschitz C
J Pediatr Gastroenterol Nutr 2008 Nov;47 Suppl 2:S58-9. doi: 10.1097/01.mpg.0000338816.82556.40. PMID: 18931604

Recent clinical studies

Etiology

Lactose Intolerance versus Cow's Milk Allergy in Infants: A Clinical Dilemma.
Darma A, Sumitro KR, Jo J, Sitorus N
Nutrients 2024 Jan 31;16(3) doi: 10.3390/nu16030414. PMID: 38337698Free PMC Article
Fortification of Breast Milk With Preterm Formula Powder vs Human Milk Fortifier in Preterm Neonates: A Randomized Noninferiority Trial.
Chinnappan A, Sharma A, Agarwal R, Thukral A, Deorari A, Sankar MJ
JAMA Pediatr 2021 Aug 1;175(8):790-796. doi: 10.1001/jamapediatrics.2021.0678. PMID: 33970187Free PMC Article
Cow's Milk Substitutes for Children: Nutritional Aspects of Milk from Different Mammalian Species, Special Formula and Plant-Based Beverages.
Verduci E, D'Elios S, Cerrato L, Comberiati P, Calvani M, Palazzo S, Martelli A, Landi M, Trikamjee T, Peroni DG
Nutrients 2019 Jul 27;11(8) doi: 10.3390/nu11081739. PMID: 31357608Free PMC Article
Cow's milk and goat's milk.
Turck D
World Rev Nutr Diet 2013;108:56-62. Epub 2013 Sep 6 doi: 10.1159/000351485. PMID: 24029787
Probiotics, prebiotics, and synbiotics.
de Vrese M, Schrezenmeir J
Adv Biochem Eng Biotechnol 2008;111:1-66. doi: 10.1007/10_2008_097. PMID: 18461293

Diagnosis

Lactose Intolerance versus Cow's Milk Allergy in Infants: A Clinical Dilemma.
Darma A, Sumitro KR, Jo J, Sitorus N
Nutrients 2024 Jan 31;16(3) doi: 10.3390/nu16030414. PMID: 38337698Free PMC Article
Optimal Nutrition Parameters for Neonates and Infants with Congenital Heart Disease.
Luca AC, Miron IC, Mîndru DE, Curpăn AȘ, Stan RC, Țarcă E, Luca FA, Pădureț AI
Nutrients 2022 Apr 17;14(8) doi: 10.3390/nu14081671. PMID: 35458233Free PMC Article
Cow's Milk Substitutes for Children: Nutritional Aspects of Milk from Different Mammalian Species, Special Formula and Plant-Based Beverages.
Verduci E, D'Elios S, Cerrato L, Comberiati P, Calvani M, Palazzo S, Martelli A, Landi M, Trikamjee T, Peroni DG
Nutrients 2019 Jul 27;11(8) doi: 10.3390/nu11081739. PMID: 31357608Free PMC Article
Infantile Colic: Recognition and Treatment.
Johnson JD, Cocker K, Chang E
Am Fam Physician 2015 Oct 1;92(7):577-82. PMID: 26447441
Chronic diarrhea.
Vanderhoof JA
Pediatr Rev 1998 Dec;19(12):418-22. doi: 10.1542/pir.19-12-418. PMID: 9849071

Therapy

Lactose Intolerance versus Cow's Milk Allergy in Infants: A Clinical Dilemma.
Darma A, Sumitro KR, Jo J, Sitorus N
Nutrients 2024 Jan 31;16(3) doi: 10.3390/nu16030414. PMID: 38337698Free PMC Article
Fortification of Breast Milk With Preterm Formula Powder vs Human Milk Fortifier in Preterm Neonates: A Randomized Noninferiority Trial.
Chinnappan A, Sharma A, Agarwal R, Thukral A, Deorari A, Sankar MJ
JAMA Pediatr 2021 Aug 1;175(8):790-796. doi: 10.1001/jamapediatrics.2021.0678. PMID: 33970187Free PMC Article
Infantile Colic: Recognition and Treatment.
Johnson JD, Cocker K, Chang E
Am Fam Physician 2015 Oct 1;92(7):577-82. PMID: 26447441
Cow's milk and goat's milk.
Turck D
World Rev Nutr Diet 2013;108:56-62. Epub 2013 Sep 6 doi: 10.1159/000351485. PMID: 24029787
Probiotics, prebiotics, and synbiotics.
de Vrese M, Schrezenmeir J
Adv Biochem Eng Biotechnol 2008;111:1-66. doi: 10.1007/10_2008_097. PMID: 18461293

Prognosis

Optimal Nutrition Parameters for Neonates and Infants with Congenital Heart Disease.
Luca AC, Miron IC, Mîndru DE, Curpăn AȘ, Stan RC, Țarcă E, Luca FA, Pădureț AI
Nutrients 2022 Apr 17;14(8) doi: 10.3390/nu14081671. PMID: 35458233Free PMC Article
Cow's milk allergy: where have we come from and where are we going?
Host A, Halken S
Endocr Metab Immune Disord Drug Targets 2014 Mar;14(1):2-8. doi: 10.2174/1871530314666140121142900. PMID: 24450456
Feeding practices and necrotizing enterocolitis.
Ramani M, Ambalavanan N
Clin Perinatol 2013 Mar;40(1):1-10. Epub 2013 Jan 17 doi: 10.1016/j.clp.2012.12.001. PMID: 23415260Free PMC Article
Inborn errors of carbohydrate metabolism.
Mayatepek E, Hoffmann B, Meissner T
Best Pract Res Clin Gastroenterol 2010 Oct;24(5):607-18. doi: 10.1016/j.bpg.2010.07.012. PMID: 20955963
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

Clinical prediction guides

Sardinian Infants of Diabetic Mothers: A Metabolomics Observational Study.
Dessì A, Bosco A, Cesare Marincola F, Pintus R, Paci G, Atzori L, Fanos V, Piras C
Int J Mol Sci 2023 Sep 6;24(18) doi: 10.3390/ijms241813724. PMID: 37762025Free PMC Article
Terahertz Spectroscopic Analysis of Lactose in Infant Formula: Implications for Detection and Quantification.
Datta S, Prasertsuk K, Khammata N, Rattanawan P, Chia JY, Jintamethasawat R, Chulapakorn T, Limpanuparb T
Molecules 2022 Aug 8;27(15) doi: 10.3390/molecules27155040. PMID: 35956992Free PMC Article
Oral Cholecystagogue Cholescintigraphy: A Systematic Review of Fatty Meal Options.
Fotos JS, Tulchinsky M
Clin Nucl Med 2015 Oct;40(10):796-8. doi: 10.1097/RLU.0000000000000913. PMID: 26222535
Safety of soya-based infant formulas in children.
Vandenplas Y, Castrellon PG, Rivas R, Gutiérrez CJ, Garcia LD, Jimenez JE, Anzo A, Hegar B, Alarcon P
Br J Nutr 2014 Apr 28;111(8):1340-60. Epub 2014 Feb 10 doi: 10.1017/S0007114513003942. PMID: 24507712
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

Recent systematic reviews

Exposure to the smell and taste of milk to accelerate feeding in preterm infants.
Delgado Paramo L, Bronnert A, Lin L, Bloomfield FH, Muelbert M, Harding JE
Cochrane Database Syst Rev 2024 May 9;5(5):CD013038. doi: 10.1002/14651858.CD013038.pub3. PMID: 38721883Free PMC Article
Protein hydrolysate versus standard formula for preterm infants.
Ng DHC, Klassen J, Embleton ND, McGuire W
Cochrane Database Syst Rev 2017 Oct 2;10(10):CD012412. doi: 10.1002/14651858.CD012412.pub2. PMID: 28968486Free PMC Article
Oral Cholecystagogue Cholescintigraphy: A Systematic Review of Fatty Meal Options.
Fotos JS, Tulchinsky M
Clin Nucl Med 2015 Oct;40(10):796-8. doi: 10.1097/RLU.0000000000000913. PMID: 26222535
Soy formula for prevention of allergy and food intolerance in infants.
Osborn DA, Sinn J
Cochrane Database Syst Rev 2006 Oct 18;2006(4):CD003741. doi: 10.1002/14651858.CD003741.pub4. PMID: 17054183Free PMC Article
Soy formula for prevention of allergy and food intolerance in infants.
Osborn DA, Sinn J
Cochrane Database Syst Rev 2004;(3):CD003741. doi: 10.1002/14651858.CD003741.pub2. PMID: 15266499

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