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Growth hormone-producing pituitary gland adenoma

MedGen UID:
82999
•Concept ID:
C0278864
•
Neoplastic Process
Synonym: Somatotrophinoma
 
Monarch Initiative: MONDO:0006238
Orphanet: ORPHA96256

Definition

An adenoma of the anterior lobe of the pituitary gland that produces growth hormone. The vast majority of cases are hormonally functioning and are associated with either gigantism or acromegaly. [from MONDO]

Professional guidelines

PubMed

Acromegaly: pathogenesis, diagnosis, and management.
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S
Lancet Diabetes Endocrinol 2022 Nov;10(11):804-826. Epub 2022 Oct 6 doi: 10.1016/S2213-8587(22)00244-3. PMID: 36209758
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Recent clinical studies

Etiology

Genetic diagnosis in acromegaly and gigantism: From research to clinical practice.
Ramírez-Rentería C, Hernández-Ramírez LC
Best Pract Res Clin Endocrinol Metab 2024 May;38(3):101892. Epub 2024 Mar 13 doi: 10.1016/j.beem.2024.101892. PMID: 38521632
Real-world experience with 11C-methionine positron emission tomography in the management of acromegaly.
Haberbosch L, MacFarlane J, Koulouri O, Gillett D, Powlson AS, Oddy S, Halsall DJ, Huynh KA, Jones J, Cheow HK, Spranger J, Mai K, Strasburger CJ, Mannion RJ, Gurnell M
Eur J Endocrinol 2024 Mar 30;190(4):307-313. doi: 10.1093/ejendo/lvae028. PMID: 38482632
Thyroid and colorectal cancer screening in acromegaly patients: should it be different from that in the general population?
Terzolo M, Puglisi S, Reimondo G, Dimopoulou C, Stalla GK
Eur J Endocrinol 2020 Oct;183(4):D1-D13. doi: 10.1530/EJE-19-1009. PMID: 32698136
MANAGEMENT OF ENDOCRINE DISEASE: Personalized medicine in the treatment of acromegaly.
Kasuki L, Wildemberg LE, Gadelha MR
Eur J Endocrinol 2018 Mar;178(3):R89-R100. Epub 2018 Jan 16 doi: 10.1530/EJE-17-1006. PMID: 29339530
The growth hormone-prolactin relationship: a neglected issue.
Laron Z
Pediatr Endocrinol Rev 2011 Dec;9(2):546-8. PMID: 22397138

Diagnosis

Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Pituitary-Tumor Endocrinopathies.
Melmed S
N Engl J Med 2020 Mar 5;382(10):937-950. doi: 10.1056/NEJMra1810772. PMID: 32130815
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Acromegaly pathogenesis and treatment.
Melmed S
J Clin Invest 2009 Nov;119(11):3189-202. Epub 2009 Nov 2 doi: 10.1172/JCI39375. PMID: 19884662Free PMC Article

Therapy

Real-world value of cabergoline in the treatment of acromegaly.
Shimon I
Best Pract Res Clin Endocrinol Metab 2024 Jul;38(4):101887. Epub 2024 Feb 28 doi: 10.1016/j.beem.2024.101887. PMID: 38443225
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Medical progress: Acromegaly.
Melmed S
N Engl J Med 2006 Dec 14;355(24):2558-73. doi: 10.1056/NEJMra062453. PMID: 17167139

Prognosis

Real-world value of cabergoline in the treatment of acromegaly.
Shimon I
Best Pract Res Clin Endocrinol Metab 2024 Jul;38(4):101887. Epub 2024 Feb 28 doi: 10.1016/j.beem.2024.101887. PMID: 38443225
Molecular targets in acromegaly.
Labadzhyan A, Melmed S
Front Endocrinol (Lausanne) 2022;13:1068061. Epub 2022 Dec 5 doi: 10.3389/fendo.2022.1068061. PMID: 36545335Free PMC Article
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Acromegaly.
Chanson P, Salenave S, Kamenicky P
Handb Clin Neurol 2014;124:197-219. doi: 10.1016/B978-0-444-59602-4.00014-9. PMID: 25248589
Pituitary tumours: acromegaly.
Chanson P, Salenave S, Kamenicky P, Cazabat L, Young J
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):555-74. doi: 10.1016/j.beem.2009.05.010. PMID: 19945023

Clinical prediction guides

Real-world value of cabergoline in the treatment of acromegaly.
Shimon I
Best Pract Res Clin Endocrinol Metab 2024 Jul;38(4):101887. Epub 2024 Feb 28 doi: 10.1016/j.beem.2024.101887. PMID: 38443225
Multidisciplinary management of difficult/aggressive growth-hormone pituitary neuro-endocrine tumors.
Bianchi A, Chiloiro S, Giampietro A, Gaudino S, Calandrelli R, Mazzarella C, Caldarella C, Rigante M, Gessi M, Lauretti L, De Marinis L, Olivi A, Pontecorvi A, Doglietto F
Front Endocrinol (Lausanne) 2023;14:1123267. Epub 2023 May 3 doi: 10.3389/fendo.2023.1123267. PMID: 37206441Free PMC Article
Molecular targets in acromegaly.
Labadzhyan A, Melmed S
Front Endocrinol (Lausanne) 2022;13:1068061. Epub 2022 Dec 5 doi: 10.3389/fendo.2022.1068061. PMID: 36545335Free PMC Article
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Recent systematic reviews

Efficacy and safety of radiosurgery in acromegaly.
Albano L, Losa M, Garbin E, Pompeo E, Barzaghi LR, Mortini P
Best Pract Res Clin Endocrinol Metab 2024 Jul;38(4):101898. Epub 2024 Apr 29 doi: 10.1016/j.beem.2024.101898. PMID: 38806304
Metabolomics in acromegaly: a systematic review.
Pînzariu O, Georgescu CE
J Investig Med 2023 Aug;71(6):634-645. Epub 2023 May 4 doi: 10.1177/10815589231169452. PMID: 37139720
Reported outcomes in transsphenoidal surgery for pituitary adenomas: a systematic review.
Layard Horsfall H, Lawrence A, Venkatesh A, Loh RTS, Jayapalan R, Koulouri O, Sharma R, Santarius T, Gurnell M, Dorward N, Mannion R, Marcus HJ, Kolias AG
Pituitary 2023 Apr;26(2):171-181. Epub 2023 Mar 2 doi: 10.1007/s11102-023-01303-w. PMID: 36862265Free PMC Article
Epithelial-Mesenchymal Transition in the Resistance to Somatostatin Receptor Ligands in Acromegaly.
Gil J, Jordà M, Soldevila B, Puig-Domingo M
Front Endocrinol (Lausanne) 2021;12:646210. Epub 2021 Mar 15 doi: 10.3389/fendo.2021.646210. PMID: 33790868Free PMC Article
Endoscopic Endonasal versus Microsurgical Transsphenoidal Approach for Growth Hormone-Secreting Pituitary Adenomas-Systematic Review and Meta-Analysis.
Phan K, Xu J, Reddy R, Kalakoti P, Nanda A, Fairhall J
World Neurosurg 2017 Jan;97:398-406. Epub 2016 Oct 15 doi: 10.1016/j.wneu.2016.10.029. PMID: 27756664

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