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Acromegaly

MedGen UID:
1304
Concept ID:
C0001206
Disease or Syndrome
Synonym: Pituitary giant
SNOMED CT: Acromegaly (74107003); Growth hormone hypersecretion syndrome (74107003); STH hypersecretion syndrome (74107003); Marie disease (74107003); Anterior pituitary adenoma syndrome (74107003); Acromegalia (74107003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019933
Orphanet: ORPHA963

Definition

A rare acquired endocrine disease related to excessive production of growth hormone (GH) and characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcromegaly
Follow this link to review classifications for Acromegaly in Orphanet.

Professional guidelines

PubMed

Giustina A, Biermasz N, Casanueva FF, Fleseriu M, Mortini P, Strasburger C, van der Lely AJ, Wass J, Melmed S; Acromegaly Consensus Group
Pituitary 2024 Feb;27(1):7-22. Epub 2023 Nov 3 doi: 10.1007/s11102-023-01360-1. PMID: 37923946Free PMC Article
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S
Lancet Diabetes Endocrinol 2022 Nov;10(11):804-826. Epub 2022 Oct 6 doi: 10.1016/S2213-8587(22)00244-3. PMID: 36209758

Recent clinical studies

Etiology

Giustina A, Biermasz N, Casanueva FF, Fleseriu M, Mortini P, Strasburger C, van der Lely AJ, Wass J, Melmed S; Acromegaly Consensus Group
Pituitary 2024 Feb;27(1):7-22. Epub 2023 Nov 3 doi: 10.1007/s11102-023-01360-1. PMID: 37923946Free PMC Article
Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C, Bolanowski M, Bonert V, Bronstein MD, Casanueva FF, Clemmons D, Colao A, Ferone D, Fleseriu M, Frara S, Gadelha MR, Ghigo E, Gurnell M, Heaney AP, Ho K, Ioachimescu A, Katznelson L, Kelestimur F, Kopchick J, Krsek M, Lamberts S, Losa M, Luger A, Maffei P, Marazuela M, Mazziotti G, Mercado M, Mortini P, Neggers S, Pereira AM, Petersenn S, Puig-Domingo M, Salvatori R, Shimon I, Strasburger C, Tsagarakis S, van der Lely AJ, Wass J, Zatelli MC, Melmed S
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgz096. PMID: 31606735
Puglisi S, Terzolo M
Endocrinol Metab Clin North Am 2019 Dec;48(4):779-793. Epub 2019 Sep 17 doi: 10.1016/j.ecl.2019.08.008. PMID: 31655776
Mazziotti G, Maffezzoni F, Frara S, Giustina A
Pituitary 2017 Feb;20(1):63-69. doi: 10.1007/s11102-016-0758-6. PMID: 27709412
Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2014 Nov;99(11):3933-51. Epub 2014 Oct 30 doi: 10.1210/jc.2014-2700. PMID: 25356808

Diagnosis

Weinreb J, Arora S
N Engl J Med 2023 Jan 5;388(1):70. doi: 10.1056/NEJMicm2205570. PMID: 36599064
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Nat Rev Dis Primers 2019 Mar 21;5(1):21. doi: 10.1038/s41572-019-0076-1. PMID: 30899021
Mazziotti G, Maffezzoni F, Frara S, Giustina A
Pituitary 2017 Feb;20(1):63-69. doi: 10.1007/s11102-016-0758-6. PMID: 27709412
Yousseif A, Karra E, Baldeweg SE
Br J Hosp Med (Lond) 2012 Aug;73(8):C119-23. doi: 10.12968/hmed.2012.73.sup8.c119. PMID: 22875534

Therapy

Gadelha MR, Gadelha AC, Kasuki L
J Clin Endocrinol Metab 2024 Mar 15;109(4):e1323-e1327. doi: 10.1210/clinem/dgad568. PMID: 37757837Free PMC Article
Gadelha MR, Wildemberg LE, Kasuki L
J Clin Endocrinol Metab 2022 Jan 18;107(2):297-308. doi: 10.1210/clinem/dgab726. PMID: 34618894Free PMC Article
Fattah S, Brayden DJ
Ther Deliv 2017 Oct;8(10):867-878. doi: 10.4155/tde-2017-0064. PMID: 28944744
Goffin V, Touraine P
Curr Opin Investig Drugs 2004 Apr;5(4):463-8. PMID: 15134290
Lancet 1975 May 10;1(7915):1076. PMID: 48738

Prognosis

Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
Daly AF, Beckers A
Endocrinol Metab Clin North Am 2020 Sep;49(3):347-355. Epub 2020 Jun 10 doi: 10.1016/j.ecl.2020.04.002. PMID: 32741475
Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM, Pivonello R
Nat Rev Dis Primers 2019 Mar 21;5(1):20. doi: 10.1038/s41572-019-0071-6. PMID: 30899019
Colao A, Merola B, Ferone D, Lombardi G
J Clin Endocrinol Metab 1997 Sep;82(9):2777-81. doi: 10.1210/jcem.82.9.4257. PMID: 9284694
Bengtsson BA
J Pediatr Endocrinol 1993 Jan-Mar;6(1):73-8. doi: 10.1515/jpem.1993.6.1.73. PMID: 8374693

Clinical prediction guides

Cuny T, Maione L, Störmann S
Clin Endocrinol (Oxf) 2024 Dec;101(6):602-604. Epub 2024 Oct 7 doi: 10.1111/cen.15147. PMID: 39373288
Danilowicz K, Sosa S
Arch Med Res 2023 Dec;54(8):102914. Epub 2023 Nov 24 doi: 10.1016/j.arcmed.2023.102914. PMID: 38007382
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
Maffezzoni F, Formenti AM
Minerva Endocrinol 2018 Jun;43(2):168-182. Epub 2017 Sep 7 doi: 10.23736/S0391-1977.17.02733-X. PMID: 28880058
Pappachan JM, Buch HN
Adv Exp Med Biol 2017;956:215-237. doi: 10.1007/5584_2016_26. PMID: 27864805

Recent systematic reviews

Xiao Z, Xiao P, Wang Y, Fang C, Li Y
PLoS One 2023;18(11):e0285335. Epub 2023 Nov 30 doi: 10.1371/journal.pone.0285335. PMID: 38032888Free PMC Article
Pînzariu O, Georgescu CE
J Investig Med 2023 Aug;71(6):634-645. Epub 2023 May 4 doi: 10.1177/10815589231169452. PMID: 37139720
Camerini S, Wennberg A, Adriani M, Martin B, Vettor R, Maffei P, Dassie F
J Endocrinol Invest 2022 Oct;45(10):1823-1834. Epub 2022 Mar 23 doi: 10.1007/s40618-022-01782-x. PMID: 35322391Free PMC Article
Bandeira DB, Olivatti TOF, Bolfi F, Boguszewski CL, Dos Santos Nunes-Nogueira V
Pituitary 2022 Jun;25(3):352-362. Epub 2022 Jan 30 doi: 10.1007/s11102-022-01208-0. PMID: 35098440
Pita-Gutierrez F, Pertega-Diaz S, Pita-Fernandez S, Pena L, Lugo G, Sangiao-Alvarellos S, Cordido F
PLoS One 2013;8(4):e61523. Epub 2013 Apr 25 doi: 10.1371/journal.pone.0061523. PMID: 23634209Free PMC Article

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